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Marianna Minnetti Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Valeria Hasenmajer Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Riccardo Pofi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Mary Anna Venneri Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Krystallenia I Alexandraki Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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adrenal hormones play a pivotal role in mitigating or enhancing the effects of clock genes on their own targets. The exact role of glucocorticoids in this context has yet to be fully elucidated. However, it is generally accepted that their circadian rhythm

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Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nathan Appanna Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anna Sharp Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Beverly A Hughes Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK

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Dena Digweed Diurnal Ltd, Cardiff, UK

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Martin J Whitaker Diurnal Ltd, Cardiff, UK

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Richard Ross Department of Oncology and Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK

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Wiebke Arlt Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK

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Trevor M Penning Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Karen Morris Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Sherly George Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Brian G Keevil Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Introduction Glucocorticoids (GCs) are steroid hormones that are released in response to stress and play a crucial role in inflammation and in carbohydrate, lipid and protein metabolism. Within key metabolic target tissues, notably the liver

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Stephen G Matthews Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Departments of Obstetrics & Gynaecology and Medicine, University of Toronto, Toronto, Ontario, Canada
Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

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Patrick O McGowan Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Biological Sciences and Center for Environmental Epigenetics and Development, University of Toronto, Scarborough, Ontario, Canada
Department of Cell and Systems Biology, Department of Psychology, University of Toronto, Toronto, Ontario, Canada

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maternal stress/anxiety/depression, maternal obesity, maternal glucocorticoid exposure and altered level of maternal care. While early studies in the field were confined to animal models, more recently, they have been extended to include humans. The

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Rachel V Richardson University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emma J Batchen University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Adrian J W Thomson Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Rowan Darroch University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Xinlu Pan University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Eva A Rog-Zielinska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Wiktoria Wyrzykowska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Kathleen Scullion University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emad A S Al-Dujaili Dietetics, Nutrition, and Biological Sciences Department, Queen Margaret University, Musselburgh, UK

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Mary E Diaz University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Carmel M Moran University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Christopher J Kenyon University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Gillian A Gray University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Introduction Corticosteroids, mineralocorticoids and glucocorticoids, exert a variety of effects on the cardiovascular system. Excessive glucocorticoid levels, whether endogenous as in Cushing’s disease, or exogenous through pharmacotherapy

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Deborah M Sloboda School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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Timothy J M Moss School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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Shaofu Li School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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Stephen G Matthews School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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John R G Challis School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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John P Newnham School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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control of HPA activity in late gestation in the fetal sheep ( Keller-Wood et al . 2006 ). Hippocampal corticosteroid receptors (both type 1 (mineralocorticoid receptor, MR) and type 2 (glucocorticoid receptor, GR)) and metabolizing enzymes (11β

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S Van der Geyten Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, B-3000 Leuven, Belgium

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V M Darras Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, B-3000 Leuven, Belgium

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−9 M for T 3 ), low V max enzyme that is only capable of IRD and is relatively insensitive to PTU ( Bianco et al. 2002 ). Glucocorticoids have been demonstrated to affect thyroid function by interacting at both the central and peripheral

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Jordan E Hamden Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada

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Melody Salehzadeh Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada

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Katherine M Gray Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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Brandon J Forys Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada

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Kiran K Soma Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada

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Introduction Glucocorticoids (GCs) are steroids produced by the adrenal glands and within lymphoid organs such as the bone marrow, thymus, and spleen ( Schmidt et al . 2008 , Taves et al. 2017 ). In mice, corticosterone is the primary

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Samuel R Heaselgrave Center of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Silke Heising Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Stuart A Morgan Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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David M Carthwright Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Michael Sagmeister Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Rowan S Hardy Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Craig L Doig Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Birmingham, UK

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Nicholas Morton Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Birmingham, UK
Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK

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Kostas Tsintzas MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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Gareth G Lavery Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Birmingham, UK

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Introduction Glucocorticoids (GCs) are a class of steroid hormones critical for whole-body energy homeostasis ( Tomlinson & Stewart 2001 ). GCs serve as stress response hormones driving GC receptor-mediated transcription to alter metabolic

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Ana Tiganescu Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Melanie Hupe Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Yoshikazu Uchida Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Theodora Mauro Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Peter M Elias Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Walter M Holleran Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Introduction Glucocorticoid (GC) excess, whether of endogenous (e.g., Cushing's syndrome, stress) or exogenous (e.g., topical or systemic therapy) origin, adversely affects multiple elements of wound healing, causing prolonged discomfort and

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Jessica L Pierce Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Ke-Hong Ding Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Jianrui Xu Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Anuj K Sharma Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Kanglun Yu Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Natalia del Mazo Arbona Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zuleika Rodríguez-Santos Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Paul J Bernard Pediatric Endocrine Specialists of Georgia, Duluth, Georgia, USA

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Wendy B Bollag Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Physiology, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Charlie Norwood VA Medical Center, Augusta, Georgia, USA

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Maribeth H Johnson Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Mark W Hamrick Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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Dana L Begun Department of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Xing-Ming Shi Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Carlos M Isales Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Augusta University, Augusta, Georgia, USA

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Meghan E McGee-Lawrence Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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and epigenetics. Osteoblastogenesis is influenced by pathways including Wnt/β-catenin, transforming growth factor-β (TGF-β), bone morphogenetic proteins (BMPs) and glucocorticoid signaling, among others ( Day et al. 2005 , Bennett et al. 2007

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