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Mohamed Asrih Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Genève 14, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Genève 14, Switzerland

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, insulin resistance, hypertension, and dyslipidemia, suggesting that NAFLD might be considered as the liver manifestation of the metabolic syndrome ( Marchesini et al . 2001 , Adams et al . 2005 ). The metabolic syndrome is a leading cause of mortality

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0201
Volume/Issue:
Volume 218: Issue 3
Free access
Susan Kralisch Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Anke Tönjes Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Kerstin Krause Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Judit Richter Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Ulrike Lossner Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Peter Kovacs Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Thomas Ebert Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Matthias Blüher Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Michael Stumvoll Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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Mathias Fasshauer Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
Medical Department, Leipzig University Medical Center, LIFE Study Center, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany

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and independently correlated with facets of the metabolic syndrome including obesity, insulin resistance, hypertension, and dyslipidemia in nondiabetic subjects. In agreement with this notion, circulating FGF21 is increased in T2DM compared with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0367
Volume/Issue:
Volume 216: Issue 2
Free access
Jerzy Bełtowski
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Grażyna Wójcicka
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Hieronim Jakubowski Department of Pathophysiology, Department of Microbiology and Molecular Genetics, Department of Biochemistry and Biotechnology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland
Department of Pathophysiology, Department of Microbiology and Molecular Genetics, Department of Biochemistry and Biotechnology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland

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amount of adipose tissue and (acquired) resistance to anorectic effect of this hormone ( Considine et al . 1996 ). Obesity and the accompanying metabolic syndrome are the major risk factors of atherosclerosis but the underlying mechanisms are

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0298
Volume/Issue:
Volume 204: Issue 2
Free access
Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Ganesh Panzade Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Rajesh Pandey CSIR Ayurgenomics Unit-TRISUTRA, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Sanchita Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Raj Kumar Mishra SIPS Superspeciality Hospital, Lucknow, India

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Ravi Shankar Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Anil Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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at https://doi.org/10.1530/JOE-17-0387 . Discussion In this study, we have demonstrated that miR-876-3p regulates glucose homeostasis and its dysregulation leads to obesity-associated metabolic syndrome. Since no study specific to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0387
Volume/Issue:
Volume 239: Issue 1
Free access
Isabel Huang-Doran Metabolic Research Laboratories, Wolfson Brain Imaging Centre, Institute of Metabolic Science

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Alison Sleigh Metabolic Research Laboratories, Wolfson Brain Imaging Centre, Institute of Metabolic Science

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Justin J Rochford Metabolic Research Laboratories, Wolfson Brain Imaging Centre, Institute of Metabolic Science

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Stephen O'Rahilly Metabolic Research Laboratories, Wolfson Brain Imaging Centre, Institute of Metabolic Science

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David B Savage Metabolic Research Laboratories, Wolfson Brain Imaging Centre, Institute of Metabolic Science

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direction with the loss of facial and upper limb fat preceding variable trunk fat loss. In our experience, people with this form of lipodystrophy only become insulin resistant and manifest other features of the metabolic syndrome when upper body fat loss

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0272
Volume/Issue:
Volume 207: Issue 3
Free access
Jinyu Ma Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Yuejun Wang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Jie Ding Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Shouping Zhang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Yinuo Yang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Cheng Sun Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Institute of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China

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obesity at the early stages of the disease ( Ezenwaka et al. 2014 , Heianza et al. 2015 ). Abdominal obesity is an important cause of metabolic syndromes and impairs glucose tolerance ( Hossain et al. 2007 ). Therefore, slow or prevent body weight

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0472
Volume/Issue:
Volume 249: Issue 3
Restricted access
Gabriel Forn-Cuní Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Monica Varela Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Conrado M Fernández-Rodríguez Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Antonio Figueras Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Beatriz Novoa Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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diseases are part of a condition termed metabolic syndrome. The hepatic component of metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This term comprises a wide range of progressive liver injuries including bland steatosis, variable degrees

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0398
Volume/Issue:
Volume 224: Issue 2
Free access
J Hoppmann
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N Perwitz
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B Meier
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M Fasshauer Department of Internal Medicine I, Department of Internal Medicine III, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany

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D Hadaschik
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H Lehnert
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J Klein
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metabolic syndrome ( Hotamisligil et al . 1993 , 1995 ). The crosstalk between adipocytes and macrophages which infiltrate adipose tissue in obesity is considered to be crucial for the development of the pro-inflammatory state ( Bluher 2008 ). To date, the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0292
Volume/Issue:
Volume 204: Issue 2
Free access
Thomas Nicholson Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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Chris Church MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

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Kostas Tsintzas MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

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Robert Jones MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

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Leigh Breen Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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Edward T Davis The Royal Orthopaedic Hospital NHS Foundation Trust, Northfield, Birmingham, UK

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David J Baker MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

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Simon W Jones Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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reported that the prevalence of metabolic syndrome is higher in females than in males ( Beigh & Jain 2012 ), with central adiposity being a greater risk factor for metabolic diseases in females ( Li et al. 2006 , Holliday et al. 2011 ). Contrary to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0528
Volume/Issue:
Volume 241: Issue 1
Open access
Hanna E Auvinen Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Johannes A Romijn Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Nienke R Biermasz Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Hanno Pijl Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Louis M Havekes Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Johannes W A Smit Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Patrick C N Rensen Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Alberto M Pereira Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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adaptations enabling the host to adequately coping with the stressor (fight or flight). Increased activity of the HPA axis has been linked to the development of the metabolic syndrome (MetS; Pasquali et al . 2006 ). The metabolic effects of GC are directed

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0056
Volume/Issue:
Volume 214: Issue 2
Free access