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Marcos Divino Ferreira-Junior Laboratory of Endocrine Physiology and Metabolism, Department of Physiological Sciences, Federal University of Goias, Goiânia, Brazil
Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil
University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal

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Keilah Valéria Naves Cavalcante Laboratory of Endocrine Physiology and Metabolism, Department of Physiological Sciences, Federal University of Goias, Goiânia, Brazil

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Carlos Henrique Xavier Systems Neurobiology Laboratory, Department of Physiological Sciences, Federal University of Goias, Goiânia, Brazil

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Emerielle Cristine Vanzela Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

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Antonio Carlos Boschero Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

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Paulo Matafome University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal
University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal
Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal
Polytechnic University of Coimbra, Coimbra Health School, H&T Research Center, Coimbra, Portugal

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Rodrigo Mello Gomes Laboratory of Endocrine Physiology and Metabolism, Department of Physiological Sciences, Federal University of Goias, Goiânia, Brazil
Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

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LEAP2 in inhibiting the effects evoked by ghrelin, mainly in glucose homeostasis, insulin resistance, and lipid metabolism ( Aslanipour et al. 2020 , Fittipaldi et al. 2020 , Ma et al. 2021 , Spann et al. 2021 ). Addressing the effects of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0039
Volume/Issue:
Volume 263: Issue 1
Restricted access
Carsten T Herz Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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Florian W Kiefer Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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adipose tissue browning has been linked to a lean phenotype and improved energy metabolism ( Roh et al. 2018 ). Neuronal control of WAT beiging WAT is innervated by sympathetic noradrenergic nerve fibers with various innervation densities

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0598
Volume/Issue:
Volume 241: Issue 3
Free access
Sandra Ghelardoni Dipartimento di Patologia Chirurgica Medica Molecolare e dell'Area Critica, University of Pisa, Via Roma 55, 56126 Pisa, Italy

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Grazia Chiellini Dipartimento di Patologia Chirurgica Medica Molecolare e dell'Area Critica, University of Pisa, Via Roma 55, 56126 Pisa, Italy

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Sabina Frascarelli Dipartimento di Patologia Chirurgica Medica Molecolare e dell'Area Critica, University of Pisa, Via Roma 55, 56126 Pisa, Italy

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Alessandro Saba Dipartimento di Patologia Chirurgica Medica Molecolare e dell'Area Critica, University of Pisa, Via Roma 55, 56126 Pisa, Italy

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Riccardo Zucchi Dipartimento di Patologia Chirurgica Medica Molecolare e dell'Area Critica, University of Pisa, Via Roma 55, 56126 Pisa, Italy

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. 2012 ). The response to T 1 AM may also be affected by its complex metabolism, which includes oxidative deamination (to 3-iodothyroacetic acid, TA1), deiodination (to T0AM), sulfation (to O -sulfonate-T 1 AM), acetylation (to N -acetyl-T 1 AM), and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0311
Volume/Issue:
Volume 221: Issue 1
Free access
Christy M Gliniak Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

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Line Pedersen Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

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Philipp E Scherer Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

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, angiogenesis, and differentiation (reviewed in Berg et al. 2019 ). Moreover, the manipulations at the level of a single metalloproteinase can cause major consequences on systemic metabolism. For example, the depletion of MMP14 (also occasionally referred to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0180
Volume/Issue:
Volume 259: Issue 3
Free access
Michael Rosenbaum Division of Molecular Genetics, Departments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA

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Rudolph L Leibel Division of Molecular Genetics, Departments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA

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‘glucostatic’ and ‘lipostatic’ signals reflecting, respectively, short-term and long-term energy stores and balance. Based on their studies of energy metabolism in rodents with lesions of the lateral or VMH, Keesey & Corbett (1984) proposed a hypothalamically

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0358
Volume/Issue:
Volume 223: Issue 1
Free access
Junlan Zhou
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Min Cheng Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Chan Boriboun
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Mariam M Ardehali
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Changfei Jiang Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Qinghua Liu Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Shuling Han
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David A Goukassian Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Yao-Liang Tang Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Ting C Zhao Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Ming Zhao
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Lu Cai Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Stéphane Richard Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Raj Kishore Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Gangjian Qin
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the adipose thermogenic program and triggers WAT browning; these in turn contribute to their lean phenotype, resistance to the induction of obesity, and improved glucose metabolism. Materials and methods Animals Sam68 + / − mice on C57BL background

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0727
Volume/Issue:
Volume 225: Issue 3
Free access
Patricia Joseph-Bravo Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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Lorraine Jaimes-Hoy Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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Jean-Louis Charli Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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differentially regulated in a condition- and tissue-specific manner ( McAninch & Bianco 2014 ). TH have crucial roles in basal metabolic rate, thermogenesis, lipid and carbohydrate metabolism, indicating that the hypothalamus–pituitary–thyroid (HPT) axis is an

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0593
Volume/Issue:
Volume 224: Issue 3
Free access
Steve O'Rahilly MRC Metabolic Diseases Unit, Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK

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AM 2014 20 YEARS OF LEPTIN: Leptin in common obesity and associated disorders of metabolism . Journal of Endocrinology 223 T71 – T81 . ( doi:10.1530/JOE-14-0258 ) Farooqi IS O'Rahilly S 2014 20 YEARS OF LEPTIN: Human disorders of

Article Type:
Editorial
DOI:
https://doi.org/10.1530/JOE-14-0506
Volume/Issue:
Volume 223: Issue 1
Free access
Nava Chapnik Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Yoni Genzer Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Avraham Ben-Shimon Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Masha Y Niv Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Oren Froy Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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: ancient energy gauge provides clues to modern understanding of metabolism . Cell Metabolism 1 15 – 25 . ( doi:10.1016/j.cmet.2004.12.003 ) Mack E Ziv E Reuveni H Kalma R Niv MY Jorns A Lenzen S Shafrir E 2008 Prevention of insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0625
Volume/Issue:
Volume 221: Issue 1
Free access
Ling He Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Shumei Meng Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Emily L Germain-Lee Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Sally Radovick Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Fredric E Wondisford Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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closely related p300 protein, suggesting a different role for p300 in glucose metabolism. The P300G422S knockin mouse model, containing a reconstituted phosphorylation site found in CBP, exhibited exaggerated hypoglycemia in a metformin tolerance test

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0084
Volume/Issue:
Volume 221: Issue 3
Free access