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A S Chagin Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

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D Chrysis Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

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M Takigawa Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

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E M Ritzen Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

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L Sävendahl Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

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regulation of longitudinal bone growth ( Vidal et al. 2000 , Chagin et al. 2004 ). In addition, both ERα and ERβ are expressed in growth plate cartilage from different species, including rat, rabbit and human ( Kusec et al. 1998 , Nilsson et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06364
Volume/Issue:
Volume 188: Issue 2
Free access
M Jankowski Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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D Wang Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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S Mukaddam-Daher Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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J Gutkowska Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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Introduction In the rat, maternal cardiovascular adaptation to pregnancy is initiated 2 days after implantation and is manifested by expanded stroke volume as well as increased heart contractility ( Slangen et al. 1997 ). In effect

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05702
Volume/Issue:
Volume 184: Issue 1
Free access
Alaa E S Abdel-Razik Faculty of Life Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK

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Ellen J Forty Faculty of Life Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK

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Richard J Balment Faculty of Life Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK

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Nick Ashton Faculty of Life Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK

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produces UTS in this species too. UTSRs have also been localised to the mammalian kidney: UTS mRNA has been identified in human ( Matsushita et al . 2001 ), monkey, mouse ( Elshourbagy et al . 2002 ) and rat kidneys ( Song et al . 2006 ). Ligand

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0260
Volume/Issue:
Volume 198: Issue 3
Free access
E Houdeau Laboratoire de Physiologie et Physiopathologie, UMR-CNRS 7079, Paris cedex 05, France
Unité de Neuro-Gastroentérologie et Nutrition, INRA, 31931 Toulouse cedex 9, France

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A Lévy Laboratoire de Physiologie et Physiopathologie, UMR-CNRS 7079, Paris cedex 05, France
Unité de Neuro-Gastroentérologie et Nutrition, INRA, 31931 Toulouse cedex 9, France

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S Mhaouty-Kodja Laboratoire de Physiologie et Physiopathologie, UMR-CNRS 7079, Paris cedex 05, France
Unité de Neuro-Gastroentérologie et Nutrition, INRA, 31931 Toulouse cedex 9, France

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the subsequently produced cAMP reduces myometrial inositol phosphate (InsP) production through phosphorylation of PLCβ by protein kinase A in the rat ( Dodge et al. 1999 ). Activation of rat myometrial β-AR was also reported to reduce basal and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06388
Volume/Issue:
Volume 187: Issue 2
Free access
Feng-ying Gong Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1# Shuai Fu Yuan Hu Tong, Dong Dan, Beijing 100730, China

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Yi-fan Shi Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1# Shuai Fu Yuan Hu Tong, Dong Dan, Beijing 100730, China

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Jie-ying Deng Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1# Shuai Fu Yuan Hu Tong, Dong Dan, Beijing 100730, China

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synthesis ( Gong et al. 2003 a , 2003 b , 2005 ). Furthermore, we also found the mechanism by which IFN-γ and IL-1β promoted GH-gene expression in rat pituitary GH3 cells may be different from the classical growth hormone-releasing hormone (GHRH

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06736
Volume/Issue:
Volume 190: Issue 2
Free access
H McNeill School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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E Whitworth School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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G P Vinson School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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J P Hinson School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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. 2003 ). Intracellular signalling in the zona glomerulosa has recently been reviewed ( Spät & Hunyady 2004 ). In this study, cellular proliferation in the isolated outer part of the rat adrenal was investigated, together with its relationship to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06347
Volume/Issue:
Volume 187: Issue 1
Free access
Kotaro Horiguchi Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Tom Kouki Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Ken Fujiwara Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Motoshi Kikuchi Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Takashi Yashiro Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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-GFP transgenic rat that expresses green fluorescent protein (GFP) specifically in FS cells in the anterior pituitary. Using S100b-GFP rat anterior pituitary cells, we found that gap junctional cell-to-cell communication was immunohistochemically reconstructed

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0297
Volume/Issue:
Volume 208: Issue 3
Free access
Yi Zhang Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Yunfeng Liu Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Jihong Qu Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Alexandre Hardy Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Nina Zhang Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Jingyu Diao Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Paul J Strijbos Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Robert Tsushima Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Richard B Robinson Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Herbert Y Gaisano Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Qinghua Wang Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Michael B Wheeler Departments of Physiology and Medicine, Department of Pharmacology, Division of Endocrinology and Metabolism, Neurology and GI Centre of Excellence for Drug Discovery, University of Toronto, Room 7310, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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previously ( MacDonald et al . 2001 ). Animal procedures were performed in accordance with the University of Toronto's Animal Care Committee's ethical guidelines. To obtain single islet cells, the intact rat islets were dispersed in dispase II solution

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0068
Volume/Issue:
Volume 203: Issue 1
Free access
A L Markel
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O E Redina
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M A Gilinsky Laboratory of Evolutionary Genetics, Laboratory of Adaptation Processes Regulation, Laboratory of Genome Structure, Laboratory of Pathophysiology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Lavrentieva Avenue, 630090 Novosibirsk, Russia

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G M Dymshits Laboratory of Evolutionary Genetics, Laboratory of Adaptation Processes Regulation, Laboratory of Genome Structure, Laboratory of Pathophysiology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Lavrentieva Avenue, 630090 Novosibirsk, Russia

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E V Kalashnikova Laboratory of Evolutionary Genetics, Laboratory of Adaptation Processes Regulation, Laboratory of Genome Structure, Laboratory of Pathophysiology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Lavrentieva Avenue, 630090 Novosibirsk, Russia

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Yu V Khvorostova Laboratory of Evolutionary Genetics, Laboratory of Adaptation Processes Regulation, Laboratory of Genome Structure, Laboratory of Pathophysiology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Lavrentieva Avenue, 630090 Novosibirsk, Russia

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L A Fedoseeva Laboratory of Evolutionary Genetics, Laboratory of Adaptation Processes Regulation, Laboratory of Genome Structure, Laboratory of Pathophysiology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Lavrentieva Avenue, 630090 Novosibirsk, Russia

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G S Jacobson Laboratory of Evolutionary Genetics, Laboratory of Adaptation Processes Regulation, Laboratory of Genome Structure, Laboratory of Pathophysiology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Lavrentieva Avenue, 630090 Novosibirsk, Russia

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these systems are directly involved both in the stress response and arterial blood pressure regulation. A rat strain with stress-dependent arterial hypertension was developed to study its underlying genetic and physiological mechanisms ( Markel 1985

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0254
Volume/Issue:
Volume 195: Issue 3
Free access
A Tury Laboratoire d’Histologie, E.A. Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, IFR INSERM 133, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25041 Besançon Cedex, France

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G Mairet-Coello Laboratoire d’Histologie, E.A. Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, IFR INSERM 133, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25041 Besançon Cedex, France

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F Poncet Laboratoire d’Histologie, E.A. Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, IFR INSERM 133, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25041 Besançon Cedex, France

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C Jacquemard Laboratoire d’Histologie, E.A. Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, IFR INSERM 133, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25041 Besançon Cedex, France

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P Y Risold Laboratoire d’Histologie, E.A. Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, IFR INSERM 133, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25041 Besançon Cedex, France

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D Fellmann Laboratoire d’Histologie, E.A. Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, IFR INSERM 133, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25041 Besançon Cedex, France

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B Griffond Laboratoire d’Histologie, E.A. Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, IFR INSERM 133, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25041 Besançon Cedex, France

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Introduction The rat quiescin sulfhydryl oxidase (rQSOX), a 64 kDa glycoprotein, is a member of the quiescin Q6/FAD (flavin adenine dinucleotide)-dependent sulfhydryl oxidase (QSOX) family ( Hoober et al. 1999 a , Benayoun et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05842
Volume/Issue:
Volume 183: Issue 2
Free access