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Júlio Cezar de Oliveira Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil
Departamento de Ciências Fisiológicas, Laboratório de Fisiologia Endócrina, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, Brazil

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Egberto Gaspar de Moura Departamento de Ciências Fisiológicas, Laboratório de Fisiologia Endócrina, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

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Rosiane Aparecida Miranda Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Ana Maria Praxedes de Moraes Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil

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Luiz Felipe Barella Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil

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Ellen Paula Santos da Conceição Departamento de Ciências Fisiológicas, Laboratório de Fisiologia Endócrina, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

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Rodrigo Mello Gomes Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, Brazil

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Tatiane Aparecida Ribeiro Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil

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Ananda Malta Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil

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Isabela Peixoto Martins Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil

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Claudinéia Conationi da Silva Franco Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil

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Patrícia Cristina Lisboa Departamento de Ciências Fisiológicas, Laboratório de Fisiologia Endócrina, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

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Paulo Cezar de Freitas Mathias Laboratório de Biologia Celular da Secreção, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil

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male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis . Diabetes 61 1072 – 1081 . ( https://doi.org/10.2337/db11-1136 ) 22415878 10.2337/db11-1136 Miranda RA da Silva Franco

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Juliane K Czeczor Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Amanda J Genders Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Kathryn Aston-Mourney Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Timothy Connor Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Liam G Hall Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Kyoko Hasebe Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Megan Ellis Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Kirstie A De Jong Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Darren C Henstridge Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Peter J Meikle Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Mark A Febbraio Division of Diabetes and Metabolism, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Ken Walder Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Sean L McGee Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia
Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein . Diabetologia 54 2143 – 2151 . ( https

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Antonio Gonzalez-Bulnes
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Susana Astiz
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Cristina Ovilo Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Clemente J Lopez-Bote Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Raul Sanchez-Sanchez
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Maria L Perez-Solana
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Laura Torres-Rovira Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Miriam Ayuso Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Jorge Gonzalez Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Sarni RO Sacchi Pitta T Fernandes AP Affonso Fonseca FL Hix S Ramalho RA 2008 Non-alcoholic fatty liver disease in overweight children and its relationship with retinol serum levels . International Journal of Vitamin and Nutrition

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Li Feng Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China
Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China

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Ling Gao Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China

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Qingbo Guan Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China

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Xiaolei Hou Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China

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Qiang Wan Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China

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Xiangdong Wang Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China

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Jiajun Zhao Provincial Hospital Affiliated to Shandong University, Qianfoshan Hospital of Shandong Province, Shandong University School of Medicine, 324, Jing 5 Road, Jinan 250021, Shandong Province, People's Republic of China

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-acid oxidation by activating AMP-activated protein kinase . Nature Medicine 8 1288 – 1295 . Yang Q Graham TE Mody N Preitner F Peroni OD Zabolotny JM Kotani K Quadro L Kahn BB 2005 Serum retinol binding protein 4 contributes to insulin

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Hamza Amine Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Yacir Benomar Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Adil Haimeur Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Hafida Messaouri Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Nadia Meskini Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Mohammed Taouis Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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2 O, 80; CoSO 4 , 7 H 2 O, 0.1; KI, 0.3. The vitamin mixture provides the following amounts per kilogram of diet: retinol, 39.600 IU; cholecalciferol, 5000 IU; thiamin, 40 mg; riboflavin, 30 mg; pantothenic acid, 140 mg; pyridoxine, 20 mg; inositol

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S Khan Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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D E W Livingstone Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh, UK

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A Zielinska College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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C L Doig Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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D F Cobice Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L Esteves Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J T Y Man Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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N Z M Homer Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J R Seckl Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L MacKay SIRCAMS, School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, Edinburgh, UK

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S P Webster Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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G G Lavery Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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K E Chapman Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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B R Walker Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Clinical & Translational Research Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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R Andrew Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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& Walker BR 2012 Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis . Diabetes 61 1072 – 1081 . ( https://doi.org/10.2337/db

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Perry Barrett Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Elena Ivanova Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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E Scott Graham Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Alexander W Ross Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Dana Wilson Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Helene Plé Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Julian G Mercer Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Francis J Ebling Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Sandrine Schuhler Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Sandrine M Dupré Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Andrew Loudon Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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Peter J Morgan Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK

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, 2005 ). However, CRBPI was also noted to be highly expressed in the ependymal layer with a potential to be photoperiodically regulated ( Ross et al. 2004 ). In a capacity as a retinol transport protein, photoperiodic regulation of CRBPI would

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Sara Pepe Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Donato Iacovazzo Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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cellular retinol-binding-protein 1 gene in human cancer . Cancer Research 62 5902 – 5905 . 12384555 Ezzat S Asa SL Couldwell WT Barr CE Dodge WE Vance ML McCutcheon IE 2004 The prevalence of pituitary adenomas: a systematic review . Cancer 101

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Gisela Helfer School of Chemistry and Biosciences, University of Bradford, Bradford, UK

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Qing-Feng Wu State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

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is downstream of retinoic acid signalling. Retinol enters the tanycytes where it is synthesised to retinoic acid (RA). RA enters the nucleus and binding to its receptors RAR and RXR leads to transcription of Rarres2 , which is translated into c

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Samuel M Lee Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Muratalla Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Marta Sierra-Cruz Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Cordoba-Chacon Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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damage and fibrogenesis induced by carbon tetrachloride-mediated hepatoxicity ( Moran-Salvador et al. 2013 ) ( Table 2 ). A recent study used the lecithin:retinol acyltransferase (Lrat) promoter-driven Cre mouse model ( Greenhalgh et al. 2015 ) to knock

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