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Ying Sze Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK

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Joana Fernandes The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK

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Zofia M Kołodziejczyk Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK

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Paula J Brunton Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
Zhejiang University-University of Edinburgh Institute, International Campus, Haining, Zhejiang, P.R. China

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Introduction Stress experienced during pregnancy has detrimental effects on the offspring across the life course, beginning during fetal development, persisting through the postnatal period and into adulthood ( Glover et al. 2018 ). This

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Chad D Osterlund Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Vanessa Thompson Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Laura Hinds Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Robert L Spencer Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Introduction Corticotropin-releasing hormone (CRH) neurons of the hypothalamic–pituitary–adrenal (HPA) axis integrate stress-dependent changes in neural input and direct negative feedback effects of glucocorticoids ( Dallman et al . 1987

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Gabriele E Mattos
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Jan-Michael Heinzmann
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Stefanie Norkowski
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Jean-Christophe Helbling Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Amandine M Minni Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Marie-Pierre Moisan Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Chadi Touma
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distribution between CBG-bound GC, albumin-bound GC and the free GC fraction in the plasma is challenged when a surge of GC is released from the adrenal cortex in response to stressors. Although only free GCs are able to exert biological effects, little is

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Li Li Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Xiaohua Li Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Wenjun Zhou Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Joseph L Messina Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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kinase ( Pessin & Saltiel 2000 , Saltiel & Kahn 2001 ). There are multiple proposed pathophysiological mechanisms for the association between chronic psychological stress or depression and insulin resistance or diabetes ( Lewis et al . 1983 , Winokur

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O Kosti Centre for Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary’s School of Medicine and Dentistry, QMUL, First Floor, John Vane Science Centre, Charterhouse Square, London EC1 M 6BQ, UK
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK

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P W Raven Centre for Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary’s School of Medicine and Dentistry, QMUL, First Floor, John Vane Science Centre, Charterhouse Square, London EC1 M 6BQ, UK
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK

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D Renshaw Centre for Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary’s School of Medicine and Dentistry, QMUL, First Floor, John Vane Science Centre, Charterhouse Square, London EC1 M 6BQ, UK
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK

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J P Hinson Centre for Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary’s School of Medicine and Dentistry, QMUL, First Floor, John Vane Science Centre, Charterhouse Square, London EC1 M 6BQ, UK
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK

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directly to address the question of a relationship between emotionality and adrenal function reported no differences in basal or stressed plasma corticosterone or adrenocorticotrophic hormone (ACTH) levels between the MR and MNR strains after short

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Matthew J VandeKopple Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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Jinghai Wu Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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Lisa A Baer Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Naresh C Bal Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Santosh K Maurya Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Anuradha Kalyanasundaram Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Muthu Periasamy Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Kristin I Stanford Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Amato J Giaccia Department of Radiation Oncology, Stanford University, Stanford, CA, USA

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Nicholas C Denko Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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Ioanna Papandreou Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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. 2017 ). In this work, we investigated the impact of whole-body Hilpda loss on survival, growth and adaptation to environmental stresses. Using a novel genetically engineered mouse model, we have uncovered Hilpda’s involvement in thermoregulation and

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Bernadette M Trojanowski Institute of Physiological Chemistry, Ulm University, Ulm, Germany

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Heba H Salem Faculty of Pharmacy, Cairo University, Cairo, Egypt
Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia

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Heike Neubauer Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

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Eric Simon Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

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Martin Wagner Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm University, Ulm, Germany

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Rajkumar Dorajoo Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore

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Bernhard O Boehm Lee Kong Chiang School of Medicine, Nanyang Technological University, Singapore, Singapore
Imperial College London, London, UK

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Leticia Labriola Institute of Physiological Chemistry, Ulm University, Ulm, Germany
Department of Biochemistry, University of São Paulo, São Paulo, Brazil

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Thomas Wirth Institute of Physiological Chemistry, Ulm University, Ulm, Germany

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Bernd Baumann Institute of Physiological Chemistry, Ulm University, Ulm, Germany

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early diabetes onset in MODY4 mutation carriers ( Fajans et al. 2010 ). In this condition β-cells are stressed and forced to compensate the increased insulin demand ( Ferrannini et al. 2004 ). Thus, the occurrence of any additional β-cell stress

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Ellen H Stolte Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Aurélia F de Mazon Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Karen M Leon-Koosterziel Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Maria Jesiak Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Nic R Bury Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Armin Sturm Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Huub F J Savelkoul Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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B M Lidy Verburg van Kemenade Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Gert Flik Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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teleostean fishes ( Balment & Henderson 1987 ). In all vertebrates, glucocorticosteroids play a key regulatory role in stress responses, growth and general metabolism, reproduction and immunity ( Mommsen et al . 1999 ); and in terrestrial vertebrates, a

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Jennifer A Crookshank Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Daniel Serrano Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Gen-Sheng Wang Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Christopher Patrick Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

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Baylie S Morgan Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada

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Marie-France Paré Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Fraser W Scott Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada

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identified differences in genes involved in the endoplasmic reticulum (ER) stress response, metabolism and apoptosis in prediabetic pancreas of BBdp rats. Candidate genes and associated pathways were further investigated in pancreas and liver from non

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Ana P Pinto Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Alisson L da Rocha Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Eike B Kohama Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Rafael C Gaspar Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Fernando M Simabuco Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Fabiani G Frantz Department of Clinical, Toxicological, and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Leandro P de Moura Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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José R Pauli Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Dennys E Cintra Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Eduardo R Ropelle Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Ellen C de Freitas School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Adelino S R da Silva Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Introduction The endoplasmic reticulum (ER) is an organelle with a fundamental role in protein and lipid biosynthesis ( Ron & Walter 2007 , Eizirik et al . 2008 ). When the ER suffers some stress like the accumulation of recently synthesized

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