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The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
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The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
Zhejiang University-University of Edinburgh Institute, International Campus, Haining, Zhejiang, P.R. China
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Introduction Stress experienced during pregnancy has detrimental effects on the offspring across the life course, beginning during fetal development, persisting through the postnatal period and into adulthood ( Glover et al. 2018 ). This
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Introduction Corticotropin-releasing hormone (CRH) neurons of the hypothalamic–pituitary–adrenal (HPA) axis integrate stress-dependent changes in neural input and direct negative feedback effects of glucocorticoids ( Dallman et al . 1987
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Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
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Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
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Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
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distribution between CBG-bound GC, albumin-bound GC and the free GC fraction in the plasma is challenged when a surge of GC is released from the adrenal cortex in response to stressors. Although only free GCs are able to exert biological effects, little is
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Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
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Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
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Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
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kinase ( Pessin & Saltiel 2000 , Saltiel & Kahn 2001 ). There are multiple proposed pathophysiological mechanisms for the association between chronic psychological stress or depression and insulin resistance or diabetes ( Lewis et al . 1983 , Winokur
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
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Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
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Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
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Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
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directly to address the question of a relationship between emotionality and adrenal function reported no differences in basal or stressed plasma corticosterone or adrenocorticotrophic hormone (ACTH) levels between the MR and MNR strains after short
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. 2017 ). In this work, we investigated the impact of whole-body Hilpda loss on survival, growth and adaptation to environmental stresses. Using a novel genetically engineered mouse model, we have uncovered Hilpda’s involvement in thermoregulation and
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Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia
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Imperial College London, London, UK
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Department of Biochemistry, University of São Paulo, São Paulo, Brazil
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early diabetes onset in MODY4 mutation carriers ( Fajans et al. 2010 ). In this condition β-cells are stressed and forced to compensate the increased insulin demand ( Ferrannini et al. 2004 ). Thus, the occurrence of any additional β-cell stress
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
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Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
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Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
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Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Animal Physiology, Cell Biology and Immunology Group, Department of Biochemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
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teleostean fishes ( Balment & Henderson 1987 ). In all vertebrates, glucocorticosteroids play a key regulatory role in stress responses, growth and general metabolism, reproduction and immunity ( Mommsen et al . 1999 ); and in terrestrial vertebrates, a
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Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
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Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada
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Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada
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identified differences in genes involved in the endoplasmic reticulum (ER) stress response, metabolism and apoptosis in prediabetic pancreas of BBdp rats. Candidate genes and associated pathways were further investigated in pancreas and liver from non
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School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
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Introduction The endoplasmic reticulum (ER) is an organelle with a fundamental role in protein and lipid biosynthesis ( Ron & Walter 2007 , Eizirik et al . 2008 ). When the ER suffers some stress like the accumulation of recently synthesized