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Gary B Silberstein, Katharine Van Horn, Eva Hrabeta-Robinson, and Jennifer Compton

RANKL. RANKL is the ligand for receptor activator of nuclear factor-kappaB (RANK) and is induced by progesterone ( Fata et al. 2000 , Brisken et al. 2002 ). Pax-2 is a proto-oncogene transcription factor characterized by a paired domain and

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Tsun-Jui Liu, Hui-Chin Lai, Chih-Tai Ting, and Ping H Wang

signaling in cardiomyocytes will help elucidate how hormonal signaling modulates myocardial function. Insulin and IGF-I could prevent skeletal muscle cell atrophy and promote myogenesis through forkhead transcription factors (FOXO; Hribal et al

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Aarti D Rohira, David M Lonard, and Bert W O’Malley

production which acts by regulating stromal COUP-TFII signaling to promote decidualization. In another example, conditional deletion of the ER gene in the uterine epithelial compartment leads to loss of LIF production. Furthermore, the transcription factor

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Marcello Maggiolini and Didier Picard

that GPR30 signaling triggers lead to the induced expression of c-fos in macrophages ( Kanda & Watanabe 2003 a ) and activation of the transcription factor CREB in keratinocytes ( Kanda & Watanabe 2003 b , 2004 ). These in turn activate the

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Lei Ye, Xiaoying Li, Xiangyin Kong, Weiqing Wang, Yufang Bi, Landian Hu, Bin Cui, Xi Li, and Guang Ning

defined in the human POMC promoter, domain IV (−376 to −417) had the distinctive property of being active in DMS-79 cells but not in AtT-20 cells ( Picon et al. 1995 ). It was reported that E2 transcription factor binding was required for the activity of

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Hong-Wei Wang, Michelle Muguira, Wei-Dong Liu, Tao Zhang, Chiachen Chen, Rebecca Aucoin, Mary B Breslin, and Michael S Lan

Introduction Insulin gene transcription is regulated by both the ubiquitous and the β-cell-specific transcription factors ( Melloul et al . 2002 , Brink 2003 ). In β-cells, multiple regulatory elements in the basal insulin promoter control insulin

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Anna Milanesi, Jang-Won Lee, Qijin Xu, Laura Perin, and John S Yu

differentiate into pancreatic, exocrine, ductal and endocrine cells in culture. A recent publication showed that suppression of nestin expression in embryonic stem cells by gene silencing reduced endodermal and pancreatic transcription factor expression ( Kim

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Jay H Lo, Pinwen Peter Chiou, C M Lin, and Thomas T Chen

by first binding to the GH receptor (GHR) and then triggering signal transduction cascades resulting in physiological responses ( Argetsinger & Carter-Su 1996 ). Although several transcription factors were believed to be involved in GH signaling

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Verónica Torres-Estay, Daniela V Carreño, Ignacio F San Francisco, Paula Sotomayor, Alejandro S Godoy, and Gary J Smith

( Wen et al . 2013 ) and that the induction of VEGF was mediated by binding of the transcription factor AR and SP1 to the core promoter region of VEGF ( Eisermann et al . 2013 ). Androgen deprivation therapy (ADT), the standard treatment for advanced

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Noriko Sakai, Hiromi Terami, Shinobu Suzuki, Megumi Haga, Ken Nomoto, Nobuko Tsuchida, Ken-ichirou Morohashi, Naoaki Saito, Maki Asada, Megumi Hashimoto, Daisuke Harada, Hiroshi Asahara, Tetsuya Ishikawa, Fumiki Shimada, and Kazuhiro Sakurada

-producing cells in vitro . To achieve this, nuclear receptor subfamily 5, group A, member 1 ( NF5A1 that was previously known as SF-1 or AD4BP ) is a key molecule. NF5A1 is the steroidogenic tissue-specific transcription factor that controls the expression