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Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani

feedback mediated by the hypothalamic–pituitary–thyroid (HPT) axis and centrally regulated by TRH ( Fig. 3 ). TRH is synthesized as a prohormone in the paraventricular nucleus (PVN) of the hypothalamus and matures into the TRH tripeptide amide (pGlu

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Cyril S Anyetei-Anum, Vincent R Roggero, and Lizabeth A Allison

hypothalamic–pituitary–thyroid (HPT) axis ( Medici et al . 2015 , Mendoza & Hollenberg 2017 ). The HPT axis involves a series of signal transduction cascades, where a signal sent from the hypothalamus eventually arrives at the thyroid gland, triggering

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Guillermo Vazquez-Anaya, Bridget Martinez, José G Soñanez-Organis, Daisuke Nakano, Akira Nishiyama, and Rudy M Ortiz

suggesting that the elevated plasma levels are attributed to reduced cellular transport, and consequently contribute to the impairment of the HPT axis. Furthermore, the reduced Mct10 levels may also explain the decreasing trends in the mRNA expression

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Flavia F Bloise, Aline Cordeiro, and Tania Maria Ortiga-Carvalho

contractile function, metabolism, myogenesis and regeneration ( Simonides & van Hardeveld 2008 , Dentice et al . 2010 , Salvatore et al . 2014 ). Serum TH levels depend on the hypothalamus–pituitary–thyroid (HPT) axis, which, in turn, responds to several

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Aurea Orozco, Carlos Valverde-R, Aurora Olvera, and Carlota García-G

-specific dehalogenation, can be tailored into a family of active or inactive iodinated compounds. Hence, orchestrated by the network of neuroendocrine signals that assemble the classic hypothalamic–pituitary–thyroid axis (HPT), true TS comprise a fourth target

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Katie Wynne, Sarah Stanley, Barbara McGowan, and Steve Bloom

hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology 143 3846 –3853. Finer N 2002 Pharmacotherapy of obesity. Best

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Michael Rosenbaum and Rudolph L Leibel

–pituitary–thyroid (HPT) and hypothalamic–pituitary–gonadal (HPG) axis activity ( Mantzoros et al . 2011 ) (see Table 4 ). In a study of leptin administration to bariatric surgery patients, Korner et al . (2013) noted a non-significant increase in weight loss

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Sayaka Aizawa, Takafumi Sakai, and Ichiro Sakata

General background on the hypothalamic–pituitary–thyroid (HPT) axis . Critical Reviews in Toxicology 37 11 – 53 . doi:10.1080/10408440601123446 .

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Hannah M Eggink, Lauren L Tambyrajah, Rosa van den Berg, Isabel M Mol, Jose K van den Heuvel, Martijn Koehorst, Albert K Groen, Anita Boelen, Andries Kalsbeek, Johannes A Romijn, Patrick C N Rensen, Sander Kooijman, and Maarten R Soeters

these regions ( Fig. 5C ) and increased presence of tyrosine hydroxylase (TH), which is the rate-limiting enzyme in norepinephrine production ( Fig. 5D ). No effects of i.c.v. infusion of tLCA on the hypothalamic–pituitary–thyroid (HPT) axis were found

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Shu-Fang Xia, Xiao-Mei Duan, Xiang-Rong Cheng, Li-Mei Chen, Yan-Jun Kang, Peng Wang, Xue Tang, Yong-Hui Shi, and Guo-Wei Le

affecting TH-dependent physiological activities. Our laboratory has found that different propensities to obesity might be related to HPT axis function and deiodinases activities ( Xia et al . 2015 ). Hence, the regulation of steps involved in type 1