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Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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adding 3 μg of each into 48 μl annealing buffer (100 mM sodium chloride, 50 mM HEPES (pH 7.4)). The mixture was then incubated at 90 °C for 4 min, followed by 70 °C for 10 min. The mixture was then slowly cooled to 10 °C. The shRNA sequences were then
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. (2006) RAW-C3 and RAW 264.7 osteoclasts Mouse RT-PCR FSH increased osteoclastogenesis Sun et al. (2006) Mesenchymal stem cell, osteoclasts Human RT-PCR, WB, immunolabeling FSH increased osteoclastogenesis Feng et al. (2017
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hepatic steatosis ( Marino & Jornayvaz 2015 ). Hepatic steatosis in humans can also be virus or drug induced. Hepatitis B, C and HIV infection are all mechanistically linked to hepatic lipid accumulation, and hepatic steatosis occurs in 40–50% of HIV
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increased solubility and solved its crystal structure at 2.4 Å resolution. Leptin adopts a typical four-helical bundle cytokine structure with four anti-parallel α helices (A, B, C, and D) in an up-up-down-down arrangement ( Fig. 1 B). The C
Babu Banarasi Das University, BBD City, Lucknow, India
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Academy of Scientific and Innovative Research, CSIR-IITR, Lucknow, India
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Babu Banarasi Das University, BBD City, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-IITR, Lucknow, India
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encoded by a different gene located at chromosome 16q22.3 ( Brognard & Newton 2008 ). The structural unit of PHLPP comprises an N-terminal PH domain, leucine-rich repeat region, a phosphatase domain (PP2C) and a C-terminal PDZ binding motif ( Fig. 1 ). The
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apoptosis and decreased expression of steroidogenic acute regulatory enzyme . International Journal of Obesity 36 1047 – 1053 . ( https://doi.org/10.1038/ijo.2011.220 ) 22083551 Shang G Peng X Ji C Zhai G Ruan Y Lou Q Jin X He J Wang H
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College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China
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College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, People’s Republic of China
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( Zhang et al. 2018 ). One hour later, at 11:00 h, the blood was collected by puncture through the jugular vein and then centrifuged to separate the serum and stored at −80°C before FSH and LH assay. The pigs were killed by electric shocks, after
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Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil
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Journal of Obesity 42 1418 – 1430 . ( https://doi.org/10.1038/s41366-018-0151-9 ) Xu M Ge C Zhu L Qin Y Du C Lou D Li Q Hu L Sun Y Dai X et al . 2020 iRhom2 promotes hepatic steatosis by activating MAP3K7
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activation by PKA inhibition Decreased ligand-induced phosphorylation Decreased N/C interaction AR (K630R) Decreased p300 binding Fu et al . (2003) Enhanced co-repressor binding Gaughan et al . (2011) AR (K630Q) Acetylation mimic Increased cell cycle
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modifying enzyme O-GlcNAc transferase induces WAT browning and protects against obesity and insulin resistance ( Ruan et al. 2014 ). Activation of hypothalamic guanylyl cyclase 2C through the intestinal hormone uroguanylin has been shown to regulate