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Lisa Rice Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Charlotte E Waters Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Jennifer Eccles Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Helen Garside Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Paula Sommer Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Paul Kay Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Fiona H Blackhall Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Leo Zeef Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Brian Telfer Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Ian Stratford Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Rob Clarke Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Dave Singh Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Adam Stevens Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Anne White Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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David W Ray Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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adding 3 μg of each into 48 μl annealing buffer (100 mM sodium chloride, 50 mM HEPES (pH 7.4)). The mixture was then incubated at 90 °C for 4 min, followed by 70 °C for 10 min. The mixture was then slowly cooled to 10 °C. The shRNA sequences were then

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Se-Min Kim The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Farhath Sultana The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Steven Sims The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Judit Gimenez-Roig The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Victoria Laurencin The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anusha Pallapati The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Satish Rojekar The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tal Frolinger The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Weibin Zhou The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anisa Gumerova The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anne Macdonald The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Vitaly Ryu The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Daria Lizneva The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Funda Korkmaz The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tony Yuen The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Mone Zaidi The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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. (2006) RAW-C3 and RAW 264.7 osteoclasts Mouse RT-PCR FSH increased osteoclastogenesis Sun et al. (2006) Mesenchymal stem cell, osteoclasts Human RT-PCR, WB, immunolabeling FSH increased osteoclastogenesis Feng et al. (2017

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Caroline E Geisler School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Benjamin J Renquist School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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hepatic steatosis ( Marino & Jornayvaz 2015 ). Hepatic steatosis in humans can also be virus or drug induced. Hepatitis B, C and HIV infection are all mechanistically linked to hepatic lipid accumulation, and hepatic steatosis occurs in 40–50% of HIV

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Frank Peelman
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Lennart Zabeau
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Kedar Moharana Department of Medical Protein Research, Unit for Structural Biology, Faculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, Belgium

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Savvas N Savvides Department of Medical Protein Research, Unit for Structural Biology, Faculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, Belgium

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Jan Tavernier
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increased solubility and solved its crystal structure at 2.4 Å resolution. Leptin adopts a typical four-helical bundle cytokine structure with four anti-parallel α helices (A, B, C, and D) in an up-up-down-down arrangement ( Fig. 1 B). The C

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Alpana Mathur Herbal Research Laboratory, CSIR-Indian Institute of Toxicology Research, Lucknow, India
Babu Banarasi Das University, BBD City, Lucknow, India

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Vivek Kumar Pandey Herbal Research Laboratory, CSIR-Indian Institute of Toxicology Research, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-IITR, Lucknow, India

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Poonam Kakkar Herbal Research Laboratory, CSIR-Indian Institute of Toxicology Research, Lucknow, India
Babu Banarasi Das University, BBD City, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-IITR, Lucknow, India

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encoded by a different gene located at chromosome 16q22.3 ( Brognard & Newton 2008 ). The structural unit of PHLPP comprises an N-terminal PH domain, leucine-rich repeat region, a phosphatase domain (PP2C) and a C-terminal PDZ binding motif ( Fig. 1 ). The

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Amrutha Bagivalu Lakshminarasimha Institute of Zoology, University of Cologne, Cologne, Germany

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Madhuri Puvvada Institute of Zoology, University of Cologne, Cologne, Germany

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Matthias Hammerschmidt Institute of Zoology, University of Cologne, Cologne, Germany

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Maximilian Michel Institute of Zoology, University of Cologne, Cologne, Germany

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apoptosis and decreased expression of steroidogenic acute regulatory enzyme . International Journal of Obesity 36 1047 – 1053 . ( https://doi.org/10.1038/ijo.2011.220 ) 22083551 Shang G Peng X Ji C Zhai G Ruan Y Lou Q Jin X He J Wang H

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Xin Li State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China

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Hongjiao Li State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

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Di Zhang College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

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Guojin Xu State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China

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Jinglin Zhang Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

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Sheng Cui State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, People’s Republic of China

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( Zhang et al. 2018 ). One hour later, at 11:00 h, the blood was collected by puncture through the jugular vein and then centrifuged to separate the serum and stored at −80°C before FSH and LH assay. The pigs were killed by electric shocks, after

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Rodrigo Martins Pereira Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Kellen Cristina da Cruz Rodrigues Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Marcella Ramos Sant’Ana Laboratory of Nutritional Genomics, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Guilherme Francisco Peruca Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Ana Paula Morelli Multidisciplinary Laboratory of Food and Health, State University of Campinas, Faculty of Applied Sciences, Limeira, Brazil

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Fernando M Simabuco Multidisciplinary Laboratory of Food and Health, State University of Campinas, Faculty of Applied Sciences, Limeira, Brazil

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Adelino S R da Silva School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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Dennys Esper Cintra Laboratory of Nutritional Genomics, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Eduardo Rochete Ropelle Laboratory of Molecular Biology of Exercise (LaBMEx), Faculty of Applied Sciences, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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José Rodrigo Pauli Laboratory of Molecular Biology of Exercise (LaBMEx), Faculty of Applied Sciences, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Leandro Pereira de Moura Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Journal of Obesity 42 1418 – 1430 . ( https://doi.org/10.1038/s41366-018-0151-9 ) Xu M Ge C Zhu L Qin Y Du C Lou D Li Q Hu L Sun Y Dai X et al . 2020 iRhom2 promotes hepatic steatosis by activating MAP3K7

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Kelly Coffey Solid Tumour Target Discovery Group, The Medical School, Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, Tyne and Wear NE2 4HH, UK

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Craig N Robson Solid Tumour Target Discovery Group, The Medical School, Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, Tyne and Wear NE2 4HH, UK

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activation by PKA inhibition Decreased ligand-induced phosphorylation Decreased N/C interaction AR (K630R) Decreased p300 binding Fu et al . (2003) Enhanced co-repressor binding Gaughan et al . (2011) AR (K630Q) Acetylation mimic Increased cell cycle

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Carsten T Herz Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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Florian W Kiefer Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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modifying enzyme O-GlcNAc transferase induces WAT browning and protects against obesity and insulin resistance ( Ruan et al. 2014 ). Activation of hypothalamic guanylyl cyclase 2C through the intestinal hormone uroguanylin has been shown to regulate

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