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A Sengupta Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 67 Poultry Farm Road, New Brunswick, New Jersey 08901, USA

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D K Sarkar Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 67 Poultry Farm Road, New Brunswick, New Jersey 08901, USA

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Introduction In the pituitary, the secretion and proliferation of prolactin (PRL)-secreting lactotropes are controlled by hypothalamic hormones that act via G protein-coupled receptors, sharing the common structural and functional motif

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0125
Volume/Issue:
Volume 214: Issue 1
Free access
Marco Aurélio Liberato Costa da Veiga Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil

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Flávia Fonseca Bloise Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil

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Ricardo Henrique Costa-e-Sousa Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil

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Luana Lopes Souza Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil

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Norma Aparecida dos Santos Almeida Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil

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Karen Jesus Oliveira Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil
Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil

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Carmen Cabanelas Pazos-Moura Laboratório de Endocrinologia Molecular, Departamento de Fisiologia e Farmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil

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Introduction The active principle isolated from Cannabis sativa , Δ9-tetrahydrocannabinol (Δ9-THC), has many well-known pharmacological properties. The actions of this phytocannabinoid are mediated by two subtypes of G-protein coupled receptors, CB

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0380
Volume/Issue:
Volume 199: Issue 2
Free access
Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Veronika Pražienková Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Andrea Popelová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Barbora Mikulášková Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Jana Zemenová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
University of Chemistry and Technology, Prague, Czech Republic

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Lenka Maletínská Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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antiobesity drugs. Prolactin-releasing peptide in food intake regulation The anorexigenic neuropeptide prolactin-releasing peptide (PrRP) was initially isolated from the hypothalamus as a ligand for the human orphan G-protein-coupled receptor GPR10

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0046
Volume/Issue:
Volume 230: Issue 2
Free access
Juriaan R Metz Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

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Mark O Huising Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

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Karin Leon Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

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B M Lidy Verburg-van Kemenade Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

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Gert Flik Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

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HPI-axis ( Verburg-van Kemenade et al. 2001 , Holland et al. 2002 ), as is the case in mammals. IL-1β mediates its effects through the cell surface receptor type I (IL-1RI), which forms a receptor complex with recruit IL-1R accessory

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06640
Volume/Issue:
Volume 191: Issue 1
Free access
Sayaka Aizawa Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo‐ohkubo, Sakuraku, Saitama 338-8570, Japan

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Takafumi Sakai Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo‐ohkubo, Sakuraku, Saitama 338-8570, Japan

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Ichiro Sakata Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo‐ohkubo, Sakuraku, Saitama 338-8570, Japan

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(Pit-1), TSH-releasing hormone receptor (TRH-R), and thyroid hormone receptor beta 2 (TR-β2; Bockmann et al . 1997 ). In addition, a high density of melatonin-binding sites has been observed in the PT of many species ( Williams & Morgan 1988 , Weaver

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0388
Volume/Issue:
Volume 212: Issue 3
Free access
Giampaolo Trivellin Department of Endocrinology, Endocrinology Division, Bart's and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK
Department of Endocrinology, Endocrinology Division, Bart's and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK

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Márta Korbonits Department of Endocrinology, Endocrinology Division, Bart's and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK

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the TRβ1 receptor was compromised by AIP knockdown. AIP binding to TRβ1 is independent of the presence of T3 in mammals. In vivo siRNA studies show that AIP is indispensable for the T 3 -independent TRβ1 activation of TRH transcription but is not

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0054
Volume/Issue:
Volume 210: Issue 2
Free access
E M de Vries Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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H C van Beeren Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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M T Ackermans Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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A Kalsbeek Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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E Fliers Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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A Boelen Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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leads to local increased bioavailabilty of T 3 concentration that suppresses thyrotrophin-releasing hormone (TRH) expression in hypophysiotropic neurons of the paraventricular nucleus of the hypothalamus ( Fekete et al . 2004 , 2010 ). In addition

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0533
Volume/Issue:
Volume 224: Issue 1
Free access
Jacob C Garza Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Chung Sub Kim Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Jing Liu Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Wei Zhang Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Xin-Yun Lu Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Introduction Melanocortin-4 receptor (MC4R) in the central nervous system (CNS) plays a critical role in the control of energy balance. Activation of MC4R by α-MSH, a derivative of pro-opiomelanocortin (POMC), decreases food intake and increases

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0009
Volume/Issue:
Volume 197: Issue 3
Free access
Cyril S Anyetei-Anum Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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Vincent R Roggero Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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Lizabeth A Allison Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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, Mullur et al . 2014 , Mondal et al . 2016 , Mendoza & Hollenberg 2017 , van der Spek et al . 2017 ). Much of thyroid hormone action is mediated by the thyroid hormone receptors (TRs), members of the nuclear receptor superfamily that act as ligand

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0708
Volume/Issue:
Volume 237: Issue 1
Free access
G M Ledda-Columbano Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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A Perra Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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M Pibiri Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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F Molotzu Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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A Columbano Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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). Most of these actions are mediated by thyroid hormone ( l -tri-iodothyronine; T3) nuclear receptors (TRs) that are encoded by two genes (α and β) and are expressed as several isoforms ( Cheng 1995 , Lazar 1993 , Hoppenheimer et al. 1996 , Yen 2001

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06110
Volume/Issue:
Volume 185: Issue 3
Free access