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Simon C Lee Departments of Physiology and Medicine, University of Toronto, 1 King's College Circle (Room 3352), Toronto, Ontario, Canada M5S 1A8

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Christine A Robson-Doucette Departments of Physiology and Medicine, University of Toronto, 1 King's College Circle (Room 3352), Toronto, Ontario, Canada M5S 1A8

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Michael B Wheeler Departments of Physiology and Medicine, University of Toronto, 1 King's College Circle (Room 3352), Toronto, Ontario, Canada M5S 1A8

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were performed as previously described ( Diao et al . 2005 ). Briefly, isolated pancreatic islets from WT and UCP2KO mice were cultured in RPMI-1640 media supplemented with 11.1 mM glucose and either 100 μM STZ or vehicle for 16 h. Immediately prior to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0117
Volume/Issue:
Volume 203: Issue 1
Free access
Monique C Saleh Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, M5S 1A8 Canada

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Michael B Wheeler Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, M5S 1A8 Canada

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Catherine B Chan Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, M5S 1A8 Canada

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( Yamashita et al. 2004 ) leads to the induction of UCP2 and suppression of GSIS. Conversely, the induction of Sirt1 in β-cells improves GSIS coincident with the downregulation of UCP2 ( Moynihan et al. 2005 ). However, an important unanswered question is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06715
Volume/Issue:
Volume 190: Issue 3
Free access
A Mostyn
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J C Litten
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K S Perkins
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M C Alves-Guerra
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C Pecqueur
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B Miroux
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M E Symonds
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L Clarke
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& Cannon 1992 ), a tissue specialized for heat production via the mitochondrial uncoupling protein (UCP)-1, which is unique to brown adipose tissue. UCP1 is located in the inner mitochondrial membrane and rapidly generates heat by uncoupling the normal

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05448
Volume/Issue:
Volume 183: Issue 1
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T S McQuaid Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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M C Saleh Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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J W Joseph Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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A Gyulkhandanyan Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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J E Manning-Fox Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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J D MacLellan Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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M B Wheeler Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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C B Chan Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
Departments of Medicine and Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5F 1A8 Canada

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colorimetric assay (Stressgen, Victoria, BC, Canada). Control and ucp2 -OE islets (100 per condition) were incubated with 1 μM forskolin ± 10 μM H89 (Calbiochem, La Jolla, CA, USA) for 30 min, and washed in 0.5 ml PBS (pH 7.4). The islet cytosol was reserved

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06723
Volume/Issue:
Volume 190: Issue 3
Free access
Y-H Suh
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S-Y Kim
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H-Y Lee
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B C Jang
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J H Bae
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J-N Sohn
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J-H Bae
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S-I Suh
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J-W Park
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K-U Lee
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D-K Song
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-cells were cultured. All studies were performed on INS-1 passages between 20 and 30 in appropriate test protocols. Recombinant adenovirus preparation and transfection A full-length human UCP2 (hUCP2/pBS) and SHP (hSHP

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05675
Volume/Issue:
Volume 183: Issue 1
Free access
Esther Paulo Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Dongmei Wu Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Peter Hecker Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Yun Zhang Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Biao Wang Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Introduction Two types of UCP1 + adipocytes have been characterized by their differences in anatomic localization, developmental origin and molecular signature in rodents ( Harms & Seale 2013 , Kajimura et al. 2015 ). The classical brown

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0173
Volume/Issue:
Volume 239: Issue 2
Free access
Garam Yang Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Buk-Gu, Gwangju, Republic of Korea

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Eunjeong Hong Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Buk-Gu, Gwangju, Republic of Korea

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Sejong Oh Division of Animal Science, College of Agriculture & Life Sciences, Chonnam National University, Buk-Gu, Gwangju, Republic of Korea

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Eungseok Kim Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Buk-Gu, Gwangju, Republic of Korea

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inguinal subcutaneous WAT (iWAT) can be converted to brown-like adipocytes, called beige adipocytes. Beige adipocytes highly express uncoupling protein 1 (UCP1), which causes proton leakage from the intermembrane compartment of the mitochondria to acquire

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0185
Volume/Issue:
Volume 260: Issue 3
Restricted access
Blerina Kola Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

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Márta Korbonits Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

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–AMPK–malonyl-CoA–carnitine palmitoyltransferase 1 (CPT1)–β-oxidation–reactive oxygen species (ROS)–UCP2–NPY/AgRP–food intake ( Fig. 1 ). Figure 1 Schematic diagram showing the proposed molecules involved in the appetite-inducing effect of ghrelin. The activation of molecules highlighted in red

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0056
Volume/Issue:
Volume 202: Issue 2
Free access
Ming-sheng Ye Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Liping Luo Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Qi Guo Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Tian Su Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Peng Cheng Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China

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Yan Huang Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China

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et al. 2021 ). Brown adipose tissue (BAT) dissipates energy in the form of heat by highly expressed uncoupling protein 1 (UCP1) protein to uncouple the mitochondrial proton gradient, which is important for thermogenesis and energy balance in mammals

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0016
Volume/Issue:
Volume 252: Issue 3
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Zhe-Zhen Liao Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Xiao-Yan Qi Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Ya-Di Wang Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Jiao-Yang Li Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Qian-Qian Gu Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Can Hu Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Yin Hu Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Heng Sun Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Li Ran Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Jing Yang Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Jiang-Hua Liu Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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Xin-Hua Xiao Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China

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molecular characteristics to brown adipocytes including abundant mitochondrial content and high uncouple protein 1 (UCP-1) expression ( Ikeda et al . 2018 ). UCP-1 plays a role in mediating proton leak and induces uncoupled respiration. Through this process

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0447
Volume/Issue:
Volume 245: Issue 1
Restricted access