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Bernard Freudenthal Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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John Logan Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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Sanger Institute Mouse Pipelines Mouse Pipelines, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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Peter I Croucher Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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Graham R Williams Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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J H Duncan Bassett Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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( Alonso & Ralston 2014 ). Such studies have identified the two key regulatory pathways – canonical Wnt signalling and receptor activator of nuclear factor kappa-B ligand (RANKL)/RANK/osteoprotegerin (OPG) that respectively regulate the function of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0258
Volume/Issue:
Volume 231: Issue 1
Open access
Kevin M Sargent Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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Renee M McFee Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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Renata Spuri Gomes Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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Andrea S Cupp Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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upregulates other genes such as fibroblast growth factor 9 ( Fgf9 ) which, in addition to cementing the testis differentiation pathway, may antagonize genes such as wingless type MMTV integration site family, member 4 ( Wnt 4 ), that if overexpressed or not

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0342
Volume/Issue:
Volume 227: Issue 2
Free access
Yu Zhou Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Chao Lian Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Yingfei Lu Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Tianming Wang Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Chengcheng Zhao Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Cuilan Zhang Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Min Gong Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Jianquan Chen Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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Rong Ju Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

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-regulated genes were axon guidance, Cushing syndrome, and Wnt signaling pathway ( Fig. 3C and D ). Meanwhile, Gene Ontology (GO) analysis indicated that differentially expressed genes (DEGs) were mainly enriched in cellular process and biological regulation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0368
Volume/Issue:
Volume 262: Issue 2
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Ulla-Maj Fiúza Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK

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Alfonso Martinez Arias Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK

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is increasing evidence for the involvement of the Wnt pathway ( Palmeirim et al. 1997 , Pasini et al. 2001 , Aulehla et al. 2003 , Giudicelli & Lewis 2004 ). Looking at the Drosophila wing imaginal disc example, Notch signalling

Article Type:
Review Article
DOI:
https://doi.org/10.1677/JOE-07-0242
Volume/Issue:
Volume 194: Issue 3
Free access
Therese Standal St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia
St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia

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Rachelle W Johnson St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia

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Narelle E McGregor St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia

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Ingrid J Poulton St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia

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Patricia W M Ho St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia

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T John Martin St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia
St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia

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Natalie A Sims St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia
St.Vincent's Institute of Medical Research, Department of Medicine at St. Vincent's Hospital Melbourne, Department of Cancer Research and Molecular Medicine, 9 Princes St, Fitzroy, Victoria 3065, Australia

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to the reduced PTH1R expression or results from some dependence on gp130 cytokines by this same pathway in osteoblasts and osteocytes remains unclear. In contrast to the effect on WNT-antagonists, both Dmp1Cre.gp130 w/w and Dmp1Cre.gp130 f/f mice

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0424
Volume/Issue:
Volume 223: Issue 2
Free access
William F Powell Jr
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Kevin J Barry
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Irena Tulum
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Tatsuya Kobayashi
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Stephen E Harris Endocrine Unit, Department of Periodontics, Massachusetts General Hospital and Harvard Medical School, Thier 1101, 50 Blossom Street, Boston, Massachusetts 02114, USA

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F Richard Bringhurst
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Paola Divieti Pajevic
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-time qPCR (control=90±20 versus Ocy-PPR cKO 147±33%, n =9; P <0.01; Fig. 4 D) as well as a suppression of Wnt-signaling pathways as demonstrated by a significant reduction of Axin-2 mRNA (control=109±47 versus Ocy-PPR cKO 65±25%, n =7; P <0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0308
Volume/Issue:
Volume 209: Issue 1
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J Jeyabalan
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M Shah
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B Viollet Royal Veterinary College, Institut Cochin, Royal College Street, London NW1 0TU, UK

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C Chenu
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-catenin transcription through phosphorylation of class IIa histone deacetylase 5 ( Zhao et al . 2011 ), it is therefore probable that AMPK regulates osteoblast differentiation through crosstalk with the Wnt/β-catenin pathway. Another pathway that is important for both

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0306
Volume/Issue:
Volume 212: Issue 3
Free access
Peter J Hornsby Department of Physiology, South Texas Veterans Health Care System, and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, Texas TX 78245, USA
Department of Physiology, South Texas Veterans Health Care System, and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, Texas TX 78245, USA

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production . Trends in Endocrinology and Metabolism 13 234 – 239 . doi:10.1016/S1043-2760(02)00609-4 . Suwa T Chen M Hawks CL Hornsby PJ 2003 Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal

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Research Article
DOI:
https://doi.org/10.1530/JOE-12-0022
Volume/Issue:
Volume 214: Issue 2
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Yujiao Dai School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Peng Hao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhimei Sun School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhiyi Guo School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Hong Xu School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Lihui Xue Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Hongyu Song Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Yida Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Shuang Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Mingming Gao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Teng Si School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Yuxin Zhang School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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Yajuan Qi School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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( Narimatsu et al. 2015, Glrizes et al. 1997, Meindl-Beinker & Dooley 2008 ). Moreover, the activation of HSCs involves a string of signal transduction mechanisms, including Wnt, notch, hippo and TGF-β/Smad pathway ( Geisler & Strazzabosco 2015 ). Each

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0561
Volume/Issue:
Volume 249: Issue 2
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Wenjun Deng Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Mingyu Xu Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Rui Dong Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Yisha Yan Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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Quan Jiang Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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, bone marrow mesenchymal stem cells, and human dental pulp cells through diverse signaling pathways, such as p38 MAPK, Wnt/β-catenin, and MAPK/Akt ( Chen et al. 2020 , Zhu et al. 2020 , Son et al. 2021 ). These findings suggest that irisin plays

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0122
Volume/Issue:
Volume 262: Issue 3
Restricted access