Search Results

You are looking at 51 - 60 of 757 items for :

  • Refine by access: All content x
Clear All
Patrycja A Jazwiec Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada
The Farncombe Family Digestive Diseases Research Institute, McMaster University, Hamilton, Canada

Search for other papers by Patrycja A Jazwiec in
Google Scholar
PubMed
Close
and
Deborah M Sloboda Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada
The Farncombe Family Digestive Diseases Research Institute, McMaster University, Hamilton, Canada
Department of Pediatrics and Obstetrics and Gynecology, McMaster University, Hamilton, Canada

Search for other papers by Deborah M Sloboda in
Google Scholar
PubMed
Close

environment ( Gluckman et al. 2005 , Hanson & Gluckman 2014 ). It has been proposed, however, that when a mismatch exists between the developmental and predicted postnatal environments, these adaptations may negatively affect health and result in increased

Free access
Tracy Josephs Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

Search for other papers by Tracy Josephs in
Google Scholar
PubMed
Close
,
Hayley Waugh Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

Search for other papers by Hayley Waugh in
Google Scholar
PubMed
Close
,
Ilona Kokay Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

Search for other papers by Ilona Kokay in
Google Scholar
PubMed
Close
,
David Grattan Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

Search for other papers by David Grattan in
Google Scholar
PubMed
Close
, and
Mary Thompson Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

Search for other papers by Mary Thompson in
Google Scholar
PubMed
Close

to alterations in pregnancy-related hormones, such as oestrogen, progesterone and prolactin, as potential mediators of insulin resistance in pregnancy. However, the effects of these hormones do not fully account for the metabolic adaptations that

Free access
Hironobu Kobayashi Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Hironobu Kobayashi in
Google Scholar
PubMed
Close
,
Fukushi Kambe Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Fukushi Kambe in
Google Scholar
PubMed
Close
,
Tsuneo Imai Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Tsuneo Imai in
Google Scholar
PubMed
Close
,
Yatsuka Hibi Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Yatsuka Hibi in
Google Scholar
PubMed
Close
,
Toyone Kikumori Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Toyone Kikumori in
Google Scholar
PubMed
Close
,
Sachiko Ohmori Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Sachiko Ohmori in
Google Scholar
PubMed
Close
,
Akimasa Nakao Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Akimasa Nakao in
Google Scholar
PubMed
Close
, and
Hisao Seo Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Search for other papers by Hisao Seo in
Google Scholar
PubMed
Close

An important role for the cyclin-dependent kinase inhibitors (CDKIs), p27Kip1 and p57Kip2, in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice, which display adrenal hyperplasia. Adrenal development and function are primarily regulated by ACTH. In the present study, we investigated the effects of ACTH on the expression of p27Kip1, p57Kip2 and proliferating cell nuclear antigen (PCNA) in rat adrenals. Male Wistar rats were treated with dexametha-sone (Dex) to inhibit endogenous ACTH secretion. ACTH was then administered to the rats, and the adrenals were examined by Western blot and immunohisto-chemical analyses. Dex treatment induced shrinkage of adrenals where no PCNA-expressing cells were detected, but most of the cells expressed p27Kip1. Subsequent ACTH treatment resulted in the marked suppression of p27Kip1 expression, specifically in adrenocortical cells at 12 h after the stimulus. At 48 h, the p27Kip1 suppression still continued in the cortex, while the PCNA-expressing cells appeared mainly around the zona glomerulosa and increased at 72 h. At this time, the p27Kip1-expressing cells also appeared in the same zone. In contrast to p27Kip1, the expression of p57Kip2 was not detected in the Dex-treated adrenal. However, its expression was markedly induced by ACTH in the zona glomerulosa at 48 and 72 h. The results demonstrate that the primary site for mitogenic action of ACTH in rat adrenocortex is the zona glomerulosa, and that ACTH modulates proliferation of adrenocortical cells by regulating p27Kip1 and p57Kip2 expression in a time- and site-specific manner.

Free access
Helena A Walz Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Helena A Walz in
Google Scholar
PubMed
Close
,
Linda Härndahl Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Linda Härndahl in
Google Scholar
PubMed
Close
,
Nils Wierup Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Nils Wierup in
Google Scholar
PubMed
Close
,
Emilia Zmuda-Trzebiatowska Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Emilia Zmuda-Trzebiatowska in
Google Scholar
PubMed
Close
,
Fredrik Svennelid Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Fredrik Svennelid in
Google Scholar
PubMed
Close
,
Vincent C Manganiello Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Vincent C Manganiello in
Google Scholar
PubMed
Close
,
Thorkil Ploug Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Thorkil Ploug in
Google Scholar
PubMed
Close
,
Frank Sundler Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Frank Sundler in
Google Scholar
PubMed
Close
,
Eva Degerman Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Eva Degerman in
Google Scholar
PubMed
Close
,
Bo Ahrén Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Bo Ahrén in
Google Scholar
PubMed
Close
, and
Lena Stenson Holst Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

Search for other papers by Lena Stenson Holst in
Google Scholar
PubMed
Close

because of defective islet adaptation that glucose intolerance develops in type 2 diabetes ( Ahrén & Pacini 2005 ). The mechanism responsible for islet adaptation has not been fully established. In this study we used the RIP-PDE3B/2 mice to explore

Free access
Harleen Kaur Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

Search for other papers by Harleen Kaur in
Google Scholar
PubMed
Close
,
Beverly S Muhlhausler CSIRO Nutrition and Health, Adelaide, Australia

Search for other papers by Beverly S Muhlhausler in
Google Scholar
PubMed
Close
,
Claire T Roberts Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia

Search for other papers by Claire T Roberts in
Google Scholar
PubMed
Close
, and
Kathryn L Gatford Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

Search for other papers by Kathryn L Gatford in
Google Scholar
PubMed
Close

review. Circulating levels of GH and IGF1 change markedly in pregnancy, and new information is emerging on how this axis contributes to maternal adaptation to pregnancy, fetal–placental growth and development, particularly in humans and rodents. Exogenous

Free access
J Han The Research Institute for Children, Department of Pediatrics, Children's Hospital at New Orleans, 200 Henry Clay Avenue, New Orleans, Louisiana 70118, USA

Search for other papers by J Han in
Google Scholar
PubMed
Close
and
Y Q Liu The Research Institute for Children, Department of Pediatrics, Children's Hospital at New Orleans, 200 Henry Clay Avenue, New Orleans, Louisiana 70118, USA
The Research Institute for Children, Department of Pediatrics, Children's Hospital at New Orleans, 200 Henry Clay Avenue, New Orleans, Louisiana 70118, USA

Search for other papers by Y Q Liu in
Google Scholar
PubMed
Close

-cell adaptation and insulin secretion. Inhibition of PC with its inhibitor phenylacetic acid (PAA) prevents glucose-stimulated insulin secretion (GSIS; Farfari et al . 2000 , Liu et al . 2002 , 2005 ). We found that PAA also reduces the β-cell proliferation

Free access
Victoria Diedrich Institute of Neurobiology, Ulm University, Ulm, Germany

Search for other papers by Victoria Diedrich in
Google Scholar
PubMed
Close
,
Elena Haugg Institute of Neurobiology, Ulm University, Ulm, Germany

Search for other papers by Elena Haugg in
Google Scholar
PubMed
Close
,
Carola Dreier Institute of Neurobiology, Ulm University, Ulm, Germany

Search for other papers by Carola Dreier in
Google Scholar
PubMed
Close
, and
Annika Herwig Institute of Neurobiology, Ulm University, Ulm, Germany

Search for other papers by Annika Herwig in
Google Scholar
PubMed
Close

bottlenecks caused by their variable surroundings. Seasonal adaptations include fur changes, readjustment of thermoregulatory capacity and metabolism, precise timing of reproduction as well as pronounced annual body weight cycles and all contribute to one goal

Free access
Francesca Spiga
Search for other papers by Francesca Spiga in
Google Scholar
PubMed
Close
,
Louise R Harrison
Search for other papers by Louise R Harrison in
Google Scholar
PubMed
Close
,
Cliona P MacSweeney Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Molecular Pharmacology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK

Search for other papers by Cliona P MacSweeney in
Google Scholar
PubMed
Close
,
Fiona J Thomson Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Molecular Pharmacology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK

Search for other papers by Fiona J Thomson in
Google Scholar
PubMed
Close
,
Mark Craighead Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Molecular Pharmacology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK

Search for other papers by Mark Craighead in
Google Scholar
PubMed
Close
, and
Stafford L Lightman
Search for other papers by Stafford L Lightman in
Google Scholar
PubMed
Close

– 1124 . Chen X Herbert J 1995 Regional changes in c-fos expression in the basal forebrain and brainstem during adaptation to repeated stress: correlations with cardiovascular, hypothermic and endocrine responses . Neuroscience 64 675 – 685

Free access
Thomas G Hill Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK

Search for other papers by Thomas G Hill in
Google Scholar
PubMed
Close
,
Lorna I F Smith Diabetes Research Group, School of Cardiovascular and Metabolic Medicine and Sciences, King’s College London, London, UK

Search for other papers by Lorna I F Smith in
Google Scholar
PubMed
Close
,
Inmaculada Ruz-Maldonado Department of Internal Medicine (Endocrinology), Yale University, New Haven, Connecticut, USA

Search for other papers by Inmaculada Ruz-Maldonado in
Google Scholar
PubMed
Close
,
Peter M Jones Diabetes Research Group, School of Cardiovascular and Metabolic Medicine and Sciences, King’s College London, London, UK

Search for other papers by Peter M Jones in
Google Scholar
PubMed
Close
, and
James E Bowe Diabetes Research Group, School of Cardiovascular and Metabolic Medicine and Sciences, King’s College London, London, UK

Search for other papers by James E Bowe in
Google Scholar
PubMed
Close

and pro-survival adaptations through autocrine/paracrine signalling ( Kim et al. 2010 , Schraenen et al. 2010 , Ohara-Imaizumi et al. 2013 , Almaca et al. 2016 , Moon et al. 2020 ). In addition to the established role of the lactogenic

Open access
Richard A Ehrhardt Departments of Animal Science and Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, USA

Search for other papers by Richard A Ehrhardt in
Google Scholar
PubMed
Close
,
Andreas Foskolos Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK

Search for other papers by Andreas Foskolos in
Google Scholar
PubMed
Close
,
Sarah L Giesy Department of Animal Science, Cornell University, Ithaca, New York, USA

Search for other papers by Sarah L Giesy in
Google Scholar
PubMed
Close
,
Stephanie R Wesolowski University of Colorado School of Medicine, Aurora, Colorado, USA

Search for other papers by Stephanie R Wesolowski in
Google Scholar
PubMed
Close
,
Christopher S Krumm Department of Animal Science, Cornell University, Ithaca, New York, USA

Search for other papers by Christopher S Krumm in
Google Scholar
PubMed
Close
,
W Ronald Butler Department of Animal Science, Cornell University, Ithaca, New York, USA

Search for other papers by W Ronald Butler in
Google Scholar
PubMed
Close
,
Susan M Quirk Department of Animal Science, Cornell University, Ithaca, New York, USA

Search for other papers by Susan M Quirk in
Google Scholar
PubMed
Close
,
Matthew R Waldron Department of Animal Science, Cornell University, Ithaca, New York, USA

Search for other papers by Matthew R Waldron in
Google Scholar
PubMed
Close
, and
Yves R Boisclair Department of Animal Science, Cornell University, Ithaca, New York, USA

Search for other papers by Yves R Boisclair in
Google Scholar
PubMed
Close

adaptive metabolism in the context of lactation. Adaptive metabolism is hormonally regulated as illustrated by adaptations triggered in early lactating dairy cows by interactions among insulin, growth hormone (GH), and insulin-like growth factor (IGF)1

Free access