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euthanized by exsanguination under anesthesia with thiobutabarbital, and femoral arteries and bone marrow were harvested and frozen in liquid N 2 immediately after isolation and stored in a −80 °C freezer. Equal amounts of protein extracts were separated on
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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delivery of leptin from the hormone’s origin in peripheral adipose tissue to the hypothalamus, may function to guarantee that adequate energy is available for important anabolic processes such as bone growth and turnover and that these actions are
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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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mice, Pierce et al. (2022) , showed that low bone mass and the accumulation of bone marrow adipose tissue persisted with ageing in 21-month-old GR Osx1 mice compared to controls. In particular, GR Osx1 mice displayed impaired cortical bone growth
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Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
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Department of Adipose Management, Osaka University Graduate School of Medicine, Osaka, Japan
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Introduction The mineralocorticoid receptor (MR) is a member of the steroid receptor family of ligand activated transcription factors. MR is expressed in several tissues, including the kidney, heart, colon, brain and adipose tissue ( Armani
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, it has been suggested that PTHrP also conveys time information to articular chondrocytes ( Okubo et al. 2015 ), although definitive evidence is still lacking. Bone Bone is a specialised connective tissue that provides mechanical integrity
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systemic circulation. Studies on animals with macrophage antigen CD45.2 that were transplanted with CD45.1 + bone marrow showed that 85% of ATMs came from the transplanted tissue and only 15% were from the animals themselves ( Weisberg et al . 2003
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Introduction The ‘obesity epidemic’ in Western societies and its associated morbidity and mortality has focused the attention of the scientific community on adipose tissue in health and disease ( Abdullah et al . 2011 , Shamseddeen et al
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Institute of Reproductive Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China
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Institute of Reproductive Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China
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State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Institute of Reproductive Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China
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State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Institute of Reproductive Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China
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). It was also reported that sex hormone imbalance was causally related with visceral adipose tissue (AT) dysfunction and visceral obesity ( Zhang & Sairam 2014 ). Besides, it was found that the vertebral bone marrow fat fraction increased during the
Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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Département de Mathématiques, Université du Québec à Montréal, Montréal, Québec, Canada
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Départements de Médecine et de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Québec, Canada
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Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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lower bone mineral density, decreased bone volume/tissue volume, and weaker, more brittle bones than their wild type (WT) littermates ( Chen et al . 2014 , Roschger et al . 2014 ). The Col1a1 Jrt/+ mouse has spontaneous fractures and deformities
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
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School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
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School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
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School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
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School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
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Introduction The pluripotency of mesenchymal stem cells (MSCs) makes them a promising cell source for tissue engineering and regenerative medicine. In addition, MSCs can easily be isolated from various adult tissues, especially from the bone marrow