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Anna G Holmes Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Jose L Mesa Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Bronwyn A Neill Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Jason Chung Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Andrew L Carey Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Gregory R Steinberg Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Bruce E Kemp Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Robert J Southgate Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Graeme I Lancaster Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Clinton R Bruce Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Matthew J Watt Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Mark A Febbraio Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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. 3 C), suggesting that IL-6 may have increased fat oxidation. Figure 3 (A) Plasma free fatty acids and (B) triacylglycerol content in skeletal muscle and (C) liver from rats treated for 14 d with vehicle control (control) or 2.4 μg/day interleukin-6

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0113
Volume/Issue:
Volume 198: Issue 2
Free access
Martina Bugáňová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Helena Pelantová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martina Holubová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Šedivá Faculty of Applied Sciences, University of West Bohemia, Plzeň, Czech Republic

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Lenka Maletínská Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Železná Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Petr Kačer Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Marek Kuzma Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martin Haluzík Centre for Experimental Medicine and Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

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 μL aliquot of supernatant was mixed with 340 μL H 2 O and 60 μL phosphate buffer (1.5 M KH 2 PO 4 in D 2 O containing 2 mM NaN 3 and 0.1% (w/v) trimethylsilyl propionic acid (TSP), pH 7.4) and placed in a 5-mm NMR tube. The NMR spectra were acquired

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0478
Volume/Issue:
Volume 233: Issue 1
Free access
Eun Hee Koh Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Ah-Ram Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyunshik Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jin Hee Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hye-Sun Park Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Myoung Seok Ko Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Mi-Ok Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyuk-Joong Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Bum Joong Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyun Ju Yoo Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Su Jung Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jin Sun Oh Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Chang-Yun Woo Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jung Eun Jang Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jaechan Leem Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Myung Hwan Cho Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Ki-Up Lee Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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, proton leakage, maximal OCR, reserve capacity and non-mitochondrial OCR) were analyzed as described by Hill et al . (2012) ( Supplementary Figure 2 , see section on supplementary data given at the end of this article). Fatty acid oxidation The fatty

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0117
Volume/Issue:
Volume 225: Issue 3
Free access
Kishor Devalaraja-Narashimha Department of Cellular and Integrative Physiology, Section of Nephrology, Department of Internal Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA

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Babu J Padanilam Department of Cellular and Integrative Physiology, Section of Nephrology, Department of Internal Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
Department of Cellular and Integrative Physiology, Section of Nephrology, Department of Internal Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA

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in fat absorption efficiency between WT and Parp -KO mice were due to a difference in fat absorption, fecal lipid output was measured directly after they were fed the HF diet for 18 weeks. The percent of fatty acids content was not significantly

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0402
Volume/Issue:
Volume 205: Issue 3
Free access
Karen Oliva Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Gillian Barker Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Gregory E Rice Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Mark J Bailey Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Martha Lappas Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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needs of the growing fetus ( Buchanan & Xiang 2005 ). In women with GDM, however, peripheral insulin resistance is even more pronounced ( Colomiere et al . 2010 ), leading to increases in the circulating concentrations of fatty acids and lipids

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0010
Volume/Issue:
Volume 218: Issue 2
Free access
Junlan Zhou
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Min Cheng Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Chan Boriboun
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Mariam M Ardehali
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Changfei Jiang Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Qinghua Liu Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Shuling Han
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David A Goukassian Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Yao-Liang Tang Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Ting C Zhao Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Ming Zhao
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Lu Cai Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Stéphane Richard Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Raj Kishore Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Gangjian Qin
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Supplementary Figure S2 , see section on supplementary data given at the end of this article). This phenotypic change was accompanied by an increased expression of key thermogenic (e.g., Ucp1 , Prdm16 , Dio2 , Cidea , and E lovl3 ) as well as fatty acid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0727
Volume/Issue:
Volume 225: Issue 3
Free access
S. C. Gupta
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J. P. Thapliyal
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Injection of adrenaline in ten daily doses of 100 μg each into the chequered water-snake, Natrix piscator, stimulated glycogenolysis and lipid esterification in the liver and lipolysis in the adipose tissue of control snakes. In both thyroidectomized and control snakes plasma protein levels decreased significantly after hormone treatment, although there was no change in concentrations of muscle glycogen and plasma lactic acid. In thyroidectomized snakes, the hormone stimulated oxidation of the free fatty acids but had no significant effect on the synthesis of the triglycerides. It is suggested that in these snakes the presence of the thyroid hormones is a prerequisite for the response of most of the metabolic processes to adrenaline.

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0940333
Volume/Issue:
Volume 94: Issue 3
Restricted access
F. HERTELENDY
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H. TODD
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G. POUNDS
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It has been reported that hypoglycin and hypoglycin-like compounds, including 4-pentenoic acid, inhibit fatty acid oxidation and gluconeogenesis as well as inducing profound hypoglycaemia (Bressler, Corredor & Brendel, 1969). A vinyl group separated by two carbon atoms from the carboxyl group is apparently a structural requirement for biological effects (Corredor, Brendel & Bressler, 1967), valeric acid, the saturated analogue of 4-pentenoic acid, being inactive. In the course of investigations on insulin secretion in ruminants we observed that valerate is a very potent insulin secretogogue (Horino, Machlin, Hertelendy & Kipnis, 1968). In this communication evidence is presented which shows that 4-pentenoic acid is also a potent stimulant of insulin secretion in the sheep and, contrary to observations in non-ruminants, it can induce hyperglycaemia and inhibit lipolysis.

Four castrated male sheep (35–50 kg) were infused through a polyethylene catheter inserted into a jugular vein after a 24-h fast. Two animals received I

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0490699
Volume/Issue:
Volume 49: Issue 4
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U Totzke
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A Hubinger
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F Bairlein
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Substrate utilization and regulatory mechanisms of metabolism were studied in migratory garden warblers by measuring plasma levels of glucose, free fatty acids (FFAs), beta-hydroxybutyrate, insulin and glucagon in response to oral glucose loads. Three different physiological states were examined: (a) the autumnal migratory period on a high and (b) on a fasted low body mass level, and (c) the postmigratory period with low body mass. Glucose tolerance was better in the postmigratory lean than fat condition. However, total food deprivation of 5-7 days with fat birds reaching their lean body mass further reduced the glucose utilization rate. Initial levels of FFAs were highest in the starved, intermediate in the fat and lowest in the lean condition. Changes in plasma FFAs during glucose tolerance tests were opposite to those of the glucose levels. Ten minutes after the glucose load plasma glucagon levels decreased and insulin increased. These effects were larger in the fat than in the postmigratory lean condition. There were no differences between sexes. It appears that during premigratory and migratory periods glucose utilization may be inhibited by a more favorable oxidation of fatty acids as would be predicted by the glucose fatty acid cycle. However, the inhibition of glucose utilization seems to be counterregulated by stronger responses of insulin and glucagon. These results may be important also in the consideration of food selection during premigratory periods and refueling abilities of birds crossing ecological barriers.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1580191
Volume/Issue:
Volume 158: Issue 2
Free access
M.-Th Sutter-Dub
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A. Sfaxi
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P. Strozza
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Pregnancy and progesterone treatment of ovariectomized rats decrease glucose metabolism through the pentose-phosphate pathway in isolated female rat adipocytes. As demonstrated in previous studies, progesterone directly decreases [1-14C]glucose oxidation through the pentose-phosphate pathway and lipogenesis from [6-14C]glucose; the present study therefore compared glucose-induced lipid synthesis during pregnancy (10, 16 and 20 days of pregnancy) with the effect of progesterone treatment (5 mg/rat per day for 14 days) to shed more light on the role of this steroid in glucose metabolism during pregnancy. The inhibition of [6-14C]glucose incorporation into triacylglycerols in the progesterone-treated rats was comparable to that which occurs during late (20 days) and mid-pregnancy (16 days) but not during early pregnancy (10 days). The inhibition of fatty acid synthesis was more important as pregnancy advanced and was different from the decrease in fatty acid synthesis induced by progesterone treatment. The sensitivity to insulin was comparable in virgin, ovariectomized and progesterone-treated ovariectomized rats but not in pregnant rats. This implies that progesterone and insulin affect glucose-induced lipid synthesis by distinct processes and that the impaired glucose metabolism is characterized by a reduction in basal glucose utilization rather than by an impaired insulin response.

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0970207
Volume/Issue:
Volume 97: Issue 2
Restricted access