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There is now evidence that oestrogens and androgens can influence male and female reproductive systems. In order to accurately identify the sites of action of oestrogens and androgens, we have proceeded to the histological localization of the two oestrogen receptor (ER) subtypes, ERalpha and ERbeta, and the androgen receptor (AR) in the reproductive tissues of adult rats of both sexes. AR was detected by immunocytochemistry, while ERalpha and ERbeta were localized by both immunocytochemistry and in situ hybridization. In the pituitary gland of animals of both sexes, ERalpha was found in the majority of nuclei of secretory cells in the anterior pituitary. The intermediate and posterior lobes did not show any staining. ERbeta was not found to be expressed in any of the pituitary lobes. Using AR antibodies, nuclear staining was detected in about 50% of secretory cells of the anterior lobe, the intermediate and posterior lobes being completely unstained. In the testis, ERalpha was localized in nuclei of Leydig cells as well as in round spermatocytes and spermatids, while ERbeta could only be detected in Sertoli cell nuclei. AR immunoreactivity was found in nuclei of Sertoli, peritubular myoid and Leydig cells. In the prostate, ERbeta was observed in epithelial cells of tubulo-alveoli, while the stroma was unlabelled. ERalpha was not found to be expressed in any prostate cells. In the prostate, AR was detected in nuclei of epithelial, stromal and endothelial cells. In seminal vesicles, staining of ERalpha was found in nuclei of epithelial and stromal cells. Similar findings were observed using AR antibodies. While ERbeta mRNA could not be detected by in situ hybridization, weak staining for ERbeta was localized in epithelial cells of seminal vesicles. In the ovary, both ERalpha and ERbeta were found to be expressed. ERbeta mRNA was found in granulosa cells of growing follicles, while ERalpha was present in theca cells, interstitial gland cells and germinal epithelium. AR immunoreactivity was detected in granulosa cell nuclei in growing follicles and also in scattered interstitial cells. In the oviduct and uterus, ERalpha was observed in nuclei of epithelial cells as well as of stromal and muscle cells. Similarly, AR immunoreactivity was present in nuclei of epithelial cells, stromal and muscle cells in both the oviduct and uterus. ERbeta was not detected in the oviduct and uterus. The present findings indicate a cell-specific localization of ERalpha, ERbeta and AR in reproductive tissues in rats of both sexes. By establishing the precise sites of action of oestrogens and androgens they contribute to a better understanding of the respective role of these steroids in reproduction function.
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evolved to promote their own reproduction by dosing females with what is arguably their most powerful hormone, E 2 . Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the
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C Beaton E Jetha M Nadella K 2003 Enzymeimmunoassay of oestradiol, testosterone and progesterone in urine samples from female mice before and after insemination . Reproduction 126 407 – 414 . ( doi:10.1530/rep.0.1260407 ) deCatanzaro
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rodents, distinct male and female patterns of hepatic gene expression occur for several Cyps that are involved in steroid and drug metabolism, as well as for some proteins that function in reproduction directly via maintenance of pregnancy or indirectly
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
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major gatekeepers of pubertal onset and adult female reproduction ( Franceschini & Desroziers 2013 ). Kisspeptin neurons are localized in two hypothalamic regions: i) the RP3V including the anteroventral periventricular and the preoptic periventricular
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) Glickman SE Frank LG Pavgi S Licht P 1992b Hormonal correlates of ‘masculinization’ in female spotted hyaenas (Crocuta crocuta). 1. Infancy to sexual maturity . Journal of Reproduction and Fertility 95 451 – 462 . ( https://doi.org/10
Department of Reproductive Medicine, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
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Department of Reproductive Medicine, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
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Department of Reproductive Medicine, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
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Department of Reproductive Medicine, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
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Department of Reproductive Medicine, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
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Department of Reproductive Medicine, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
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Department of Reproductive Medicine, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
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Introduction Follicle-stimulating hormone (FSH) is critical for ovarian folliculogenesis and female fertility. FSH plays a key role in antral follicle development and, in combination with luteinizing hormone (LH), stimulates
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Department of Medicine, Hanson Institute, Department of Endocrinology, ANZAC Research Institute, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
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Department of Medicine, Hanson Institute, Department of Endocrinology, ANZAC Research Institute, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
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Introduction Males and females show sexual dimorphism in a number of tissues. Males tend to be taller, with higher muscle and bone mass and lower fat mass than females, with differences also observed in the immune system, nervous system, and in
The Farncombe Family Digestive Diseases Research Institute, McMaster University, Hamilton, Canada
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The Farncombe Family Digestive Diseases Research Institute, McMaster University, Hamilton, Canada
Department of Pediatrics and Obstetrics and Gynecology, McMaster University, Hamilton, Canada
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( Clermont 1966 , Culty 2009 ). Maternal nutritional impacts on offspring reproduction Impacts in female offspring FGR and maternal nutritional restriction Epidemiological/clinical data on growth restriction and reproduction in human
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
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IRS-2 pathways integrate female reproduction and energy homeostasis . Nature 407 377 – 382 . Carvalho CRO Carvalheira JBC Lima MHM Zimmerman SF Caperuto LC Amanso A Gasparetti AL Meneghetti V Zimmerman LF Velloso LA 2003
