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Erin Faught Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Mathilakath M Vijayan Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Introduction Both intrauterine and early postnatal environments program various physiological systems in vertebrates. Major factors affecting fetal growth include maternal nutrition and fetal stress. Excess glucocorticoids (GCs) are of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0358
Volume/Issue:
Volume 244: Issue 2
Restricted access
Marianna Minnetti Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Valeria Hasenmajer Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Riccardo Pofi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Mary Anna Venneri Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Krystallenia I Alexandraki Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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adrenal hormones play a pivotal role in mitigating or enhancing the effects of clock genes on their own targets. The exact role of glucocorticoids in this context has yet to be fully elucidated. However, it is generally accepted that their circadian rhythm

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0066
Volume/Issue:
Volume 246: Issue 2
Free access
Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nathan Appanna Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anna Sharp Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Beverly A Hughes Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK

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Dena Digweed Diurnal Ltd, Cardiff, UK

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Martin J Whitaker Diurnal Ltd, Cardiff, UK

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Richard Ross Department of Oncology and Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK

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Wiebke Arlt Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK

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Trevor M Penning Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Karen Morris Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Sherly George Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Brian G Keevil Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Introduction Glucocorticoids (GCs) are steroid hormones that are released in response to stress and play a crucial role in inflammation and in carbohydrate, lipid and protein metabolism. Within key metabolic target tissues, notably the liver

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0473
Volume/Issue:
Volume 245: Issue 2
Open access
Morag J Young Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia
Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia

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Amanda J Rickard Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia
Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia

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therapeutic approaches. Regulation of the MR epithelial vs non-epithelial mechanisms The MR is a member of the steroid hormone receptor family of ligand-activated transcription factors that share structural homology with glucocorticoid (GR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0471
Volume/Issue:
Volume 224: Issue 1
Free access
Alberto Dinarello Department of Biology, University of Padova, Padova, Italy

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Giorgio Licciardello Department of Biology, University of Padova, Padova, Italy

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Camilla Maria Fontana Department of Biology, University of Padova, Padova, Italy

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Natascia Tiso Department of Biology, University of Padova, Padova, Italy

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Francesco Argenton Department of Biology, University of Padova, Padova, Italy

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Luisa Dalla Valle Department of Biology, University of Padova, Padova, Italy

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The glucocorticoid signaling pathways Steroid hormones are lipophilic and low-molecular weight compounds broadly involved in endocrine signaling, thus, able to trigger systemic effects through bloodstream circulation. All steroid hormones

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0173
Volume/Issue:
Volume 247: Issue 3
Free access
Rachel V Richardson University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emma J Batchen University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Adrian J W Thomson Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Rowan Darroch University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Xinlu Pan University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Eva A Rog-Zielinska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Wiktoria Wyrzykowska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Kathleen Scullion University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emad A S Al-Dujaili Dietetics, Nutrition, and Biological Sciences Department, Queen Margaret University, Musselburgh, UK

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Mary E Diaz University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Carmel M Moran University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Christopher J Kenyon University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Gillian A Gray University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Introduction Corticosteroids, mineralocorticoids and glucocorticoids, exert a variety of effects on the cardiovascular system. Excessive glucocorticoid levels, whether endogenous as in Cushing’s disease, or exogenous through pharmacotherapy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0458
Volume/Issue:
Volume 232: Issue 3
Open access
Deborah M Sloboda School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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Timothy J M Moss School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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Shaofu Li School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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Stephen G Matthews School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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John R G Challis School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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John P Newnham School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia
School of Women's and Infants' Health, Women and Infants Research Foundation, Departments of Physiology and Obstetrics and Gynecology, The University of Western Australia, Perth 6009, Australia

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control of HPA activity in late gestation in the fetal sheep ( Keller-Wood et al . 2006 ). Hippocampal corticosteroid receptors (both type 1 (mineralocorticoid receptor, MR) and type 2 (glucocorticoid receptor, GR)) and metabolizing enzymes (11β

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0375
Volume/Issue:
Volume 197: Issue 2
Free access
S Van der Geyten Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, B-3000 Leuven, Belgium

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V M Darras Laboratory of Comparative Endocrinology, Zoological Institute, KU Leuven, Naamsestraat 61, B-3000 Leuven, Belgium

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−9 M for T 3 ), low V max enzyme that is only capable of IRD and is relatively insensitive to PTU ( Bianco et al. 2002 ). Glucocorticoids have been demonstrated to affect thyroid function by interacting at both the central and peripheral

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05974
Volume/Issue:
Volume 185: Issue 2
Free access
Jordan E Hamden Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada

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Melody Salehzadeh Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada

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Katherine M Gray Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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Brandon J Forys Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada

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Kiran K Soma Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada

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Introduction Glucocorticoids (GCs) are steroids produced by the adrenal glands and within lymphoid organs such as the bone marrow, thymus, and spleen ( Schmidt et al . 2008 , Taves et al. 2017 ). In mice, corticosterone is the primary

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0154
Volume/Issue:
Volume 251: Issue 2
Restricted access
P Nguyen Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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S Khurana Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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H Peltsch Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Grandbois Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Eibl Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Crispo Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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D Ansell Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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T C Tai Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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observed that exposure to high doses of glucocorticoids (GCs) during fetal development, generated either as a consequence of maternal stressors or administered antenatally also reduces birth weight and leads to development of essential hypertension later in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0244
Volume/Issue:
Volume 227: Issue 2
Free access