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Alexia Barroso, Jose Antonio Santos-Marcos, Cecilia Perdices-Lopez, Ana Vega-Rojas, Miguel Angel Sanchez-Garrido, Yelizabeta Krylova, Helena Molina-Abril, Claes Ohlsson, Pablo Perez-Martinez, Matti Poutanen, Jose Lopez-Miranda, Manuel Tena-Sempere, and Antonio Camargo

Introduction Sex steroids are key metabolic regulators in different tissues, with proven roles in the control of food intake and energy homeostasis, whose deregulation is frequently linked to the manifestation of diseases ( Mauvais-Jarvis et

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Lei Du, Yang Wang, Cong-Rong Li, Liang-Jian Chen, Jin-Yang Cai, Zheng-Rong Xia, Wen-Tao Zeng, Zi-Bin Wang, Xi-Chen Chen, Fan Hu, Dong Zhang, Xiao-Wei Xing, and Zhi-Xia Yang

used for treating obesity and metabolic diseases such as type 2 diabetes and dyslipidemia in rodents ( Villarroya et al. 2013 , 2017 , Wang et al. 2015 ). As stated previously, PCOS is frequently accompanied by abnormal metabolism ( Balen et al

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Laura D Brown

metabolic diseases in adulthood. Therefore, the objectives of this article are to i) review the fundamentals of fetal myogenesis; ii) review the experimental studies showing that fetal undernutrition from maternal dietary restriction or placental

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Yi Lin and Zhongjie Sun

. Fritsche L Weigert C Haring HU Lehmann R 2008 How insulin receptor substrate proteins regulate the metabolic capacity of the liver – implications for health and disease . Current Medicinal Chemistry 15 1316 – 1329 . Frittitta L Youngren

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Erica Yeo, Patricia L Brubaker, and Deborah M Sloboda

insulin resistance. So how does the maternal pancreas cope with the sustained insulin demand of pregnancy? Pancreatic β-cells are plastic and can respond to changes in insulin demand and, although this is pathological in metabolic diseases, this same

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Ricardo Rodríguez-Calvo, Josefa Girona, Josep M Alegret, Alba Bosquet, Daiana Ibarretxe, and Lluís Masana

diagnosis ( Loehr et al . 2008 , Writing Group et al . 2010 ). Increasing evidence has highlighted the role of metabolic diseases as important risk factors for HF. In particular, obesity has been proposed as one of the main contributors to the onset and

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Ivana Vaněčková, Lenka Maletínská, Michal Behuliak, Veronika Nagelová, Josef Zicha, and Jaroslav Kuneš

metabolic changes. The increasing knowledge about body fat distribution and its modifiers may lead to the development of more effective treatment strategies for subjects at a high risk for type 2 diabetes and coronary artery disease. It is interesting that

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Mohamed Asrih and François R Jornayvaz

Consortium NIHMMPC 2010 Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice . Disease Models & Mechanisms 3 525 – 534 . ( doi:10.1242/dmm.006239 ) Balent B Goswami G Goodloe G Rogatsky E

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Muraly Puttabyatappa, Robert M Sargis, and Vasantha Padmanabhan

Introduction Insulin resistance is a characteristic feature of many metabolic disorders, including the metabolic syndrome, type 2 diabetes mellitus (T2DM), obesity, non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS

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Thomas Nicholson, Chris Church, Kostas Tsintzas, Robert Jones, Leigh Breen, Edward T Davis, David J Baker, and Simon W Jones

implications for the treatment of metabolic diseases such as type 2 diabetes ( Bluher 2014 , Bluher & Mantzoros 2015 ). It has long been established that the accumulation of abdominal fat (central adiposity) is associated with insulin resistance ( Pratley et