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M S Fernandes, V Pierron, D Michalovich, S Astle, S Thornton, H Peltoketo, E W-F Lam, B Gellersen, I Huhtaniemi, J Allen, and J J Brosens

, predominantly through activation of the nuclear progesterone receptors (PR-A and PR-B), members of the steroid/thyroid hormone receptor superfamily of transcription factors ( Aranda & Pascual 2001 , Brosens et al. 2004 ). However, not all effects of

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Ruijin Shao, Emil Egecioglu, Birgitta Weijdegård, Karin Ljungström, Charlotte Ling, Julia Fernandez-Rodriguez, and Håkan Billig

cellular actions of this hormone are mediated primarily by the nuclear P 4 receptors (PR), including two well-studied isoforms, PRA and PRB ( Kastner et al. 1990 a ). Both isoforms function as hormone-activated transcription factors and are involved in

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Giampaolo Trivellin and Márta Korbonits

, Igreja et al . 2010 ). At first, AIP seems to be an unusual gene causing pituitary adenoma as it was previously only known as a co-chaperone of nuclear receptors or viral proteins ( Kuzhandaivelu et al . 1996 , Carver & Bradfield 1997 , Ma & Whitlock

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C Crescioli, L Cosmi, E Borgogni, V Santarlasci, S Gelmini, M Sottili, E Sarchielli, B Mazzinghi, M Francalanci, A Pezzatini, G Perigli, G B Vannelli, F Annunziato, and M Serio

the IFNγ membrane receptor. RGZ similarly decreases cytokine-induced CXCL10 secretion without affecting IFNγR expression. Interestingly, RGZ blocked TNFα-mediated nuclear translocation of NF-κB, pointing out that both drugs abrogated CXCL10

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Ana B Ropero, Pablo Juan-Picó, Alex Rafacho, Esther Fuentes, F Javier Bermúdez-Silva, Enrique Roche, Ivan Quesada, Fernando Rodríguez de Fonseca, and Angel Nadal

& Valdeolmillos 2000 ), provoking a pulsatile insulin secretion ( Gilon et al . 1993 , Barbosa et al . 1996 ). Peroxisome proliferator-activated receptors (PPARs) encompass a three-member subgroup (α, γ, and β/δ) belonging to the nuclear hormone receptor

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Gabriela Hernández-Puga, Arturo Mendoza, Alfonso León-del-Río, and Aurea Orozco

et al . 2011 ). Primary coactivators interact directly with active TRs through the nuclear receptor (NR) recognition motif (NR box) ‘ LxxLL ’ ( Savkur & Burris 2004 ). This allows the recruitment of secondary coactivators to ultimately form a

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P Venditti, G Chiellini, L Di Stefano, G Napolitano, R Zucchi, A Columbano, T S Scanlan, and S Di Meo

in tissue uptake of the agonists should seem unlikely. However, other effects including different half life, altered nuclear import, impaired inactivation by deiodinases could contribute to liver agonist concentrations. Differences in TRβ receptors

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Peter J Fuller, Yizou Yao, Jun Yang, and Morag J Young

Introduction The mineralocorticoid receptor (MR) is arguably unique amongst the nuclear receptors in that it has two physiological ligands, aldosterone and cortisol (corticosterone in rodents). There is increasing evidence that the consequences of

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Marcello Canonaco, Giuseppina Giusi, Antonio Madeo, Rosa Maria Facciolo, Rosamaria Lappano, Alessia Canonaco, and Marcello Maggiolini

on its ability to elicit transcriptional responses independently of the classical nuclear receptor isoforms. On the basis of such observations, growing attention is beginning to be focused on some major health conditions such as tumor formations in

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Helen Garside, Charlotte Waters, Andy Berry, Lisa Rice, Helen C Ardley, Anne White, Philip A Robinson, and David Ray

Introduction The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily. It is a key regulator of many homeostatic mechanisms and is also the target of therapeutic glucocorticoids used to treat inflammatory