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Maria Carolina S Mendes Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), MA: 13083-970 Campinas, Sao Paulo, Brazil

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Gustavo D Pimentel Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), MA: 13083-970 Campinas, Sao Paulo, Brazil

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Felipe O Costa Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), MA: 13083-970 Campinas, Sao Paulo, Brazil

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José B C Carvalheira Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), MA: 13083-970 Campinas, Sao Paulo, Brazil

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-associated anorexia . Journal of Pain and Symptom Management 43 78 – 86 . ( doi:10.1016/j.jpainsymman.2011.03.007 ) DeBoer MD Zhu XX Levasseur P Meguid MM Suzuki S Inui A Taylor JE Halem HA Dong JZ Datta R 2007 Ghrelin treatment causes

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0170
Volume/Issue:
Volume 226: Issue 3
Free access
Fabio Arturo Iannotti Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Campania, Italy

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Vincenzo Di Marzo Director, Joint International Research Unit for the Chemical and Biomolecular Study of the Microbiome in Metabolic Health and Nutrition (JIRU-MicroMeNu) between the Consiglio Nazionale delle Ricerche (CNR, Institute of Biomolecular Chemistry) and Université Laval, Naples, Campania, Italy
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada

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. 2018 , Laleh et al. 2019 ), and the analgesia and amelioration of behavioural deficits in models of chronic pain and autism, exerted by PEA ( Di Paola et al. 2018 , Guida et al. 2020 ). Given the lack of eCBome receptors in bacteria, it is

Article Type:
Review Article
Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-20-0444
Volume/Issue:
Volume 248: Issue 2
Free access
Elena Conte Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Adele Romano Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Michela De Bellis Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Marialuisa de Ceglia Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Maria Rosaria Carratù Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

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Silvana Gaetani Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Fatima Maqoud Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Domenico Tricarico Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Claudia Camerino Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy
Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy
Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

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different tissues ( Scala et al. 2019 ). Emerging evidence indicates that TRPV1 mediates the pain signal of Oxt in neurons ( Nersesyan et al. 2017 , Gonzalez-Hernandez & Charlet 2018 ). Circulating Oxt, other than through Oxtr, may directly interact

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0346
Volume/Issue:
Volume 249: Issue 2
Restricted access
Alpha Dian-Yu Lin Albany College of Pharmacy,
Albany Medical College,
Stratton VA Medical Center, 106 New Scotland Ave, Albany, New York 12208, USA
Taichung Poah-Ai Hospital, Taipei, Taiwan

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Anita Mannikarottu Albany College of Pharmacy,
Albany Medical College,
Stratton VA Medical Center, 106 New Scotland Ave, Albany, New York 12208, USA
Taichung Poah-Ai Hospital, Taipei, Taiwan

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Barry A Kogan Albany College of Pharmacy,
Albany Medical College,
Stratton VA Medical Center, 106 New Scotland Ave, Albany, New York 12208, USA
Taichung Poah-Ai Hospital, Taipei, Taiwan

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Catherine Whitbeck Albany College of Pharmacy,
Albany Medical College,
Stratton VA Medical Center, 106 New Scotland Ave, Albany, New York 12208, USA
Taichung Poah-Ai Hospital, Taipei, Taiwan

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Paul Chichester Albany College of Pharmacy,
Albany Medical College,
Stratton VA Medical Center, 106 New Scotland Ave, Albany, New York 12208, USA
Taichung Poah-Ai Hospital, Taipei, Taiwan

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Robert E Leggett Albany College of Pharmacy,
Albany Medical College,
Stratton VA Medical Center, 106 New Scotland Ave, Albany, New York 12208, USA
Taichung Poah-Ai Hospital, Taipei, Taiwan

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Robert M Levin Albany College of Pharmacy,
Albany Medical College,
Stratton VA Medical Center, 106 New Scotland Ave, Albany, New York 12208, USA
Taichung Poah-Ai Hospital, Taipei, Taiwan

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liquid nitrogen using a mortar and was homogenized in buffer containing 20% glycerol, 50 mM Tris–HCl (pH 6.8), 0.5% (v/v) Tween-20, and protease inhibitors (0.5 mM phenylmethanesulfonyl fluoride, 2 μM pepstatin, 2 μM anti-pain and 0.1 mg/ml trypsin

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06701
Volume/Issue:
Volume 190: Issue 2
Free access
Masafumi Amano School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Shunsuke Moriyama School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Masayuki Iigo School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Shoji Kitamura School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Noriko Amiya School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Kunio Yamamori School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Kazuyoshi Ukena School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Kazuyoshi Tsutsui School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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pain. Brain Research 848 191 –196. Parker DB , Coe IR, Dixon GH & Sherwood NM 1993 Two salmon neuropeptides encoded by one brain cDNA are structurally related to members of the glucagon superfamily. European Journal

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06494
Volume/Issue:
Volume 188: Issue 3
Free access
Galit Levi Dunietz Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Lucas J Tittle Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA

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Sunni L Mumford Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Louise M O’Brien Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

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Ana Baylin Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA

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Enrique F Schisterman Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Ronald D Chervin Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Larry J Young Center for Translational Social Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA

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neurocircuitry and observed links between OT, stress, and stress-related neurocircuitry ( Lancel et al. 2003 ). Sleep and OT have been independently associated with mood and pain, although it is unknown whether OT and sleep jointly influence mood and pain

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0396
Volume/Issue:
Volume 262: Issue 1
Restricted access
Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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, coagulation, and pain. Finally, loss of ACE2’s actions in the intestine may cause diarrhoea, nausea, and vomiting, by promoting inflammation and altering the microbiome. Adapted from American Journal of Pathology , volume 191, Ramos SG, Cruz Rattis BA de

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-22-0262
Volume/Issue:
Volume 258: Issue 3
Free access
Rick van der Geest Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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Ronald J van der Sluis Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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Albert K Groen Departments of Pediatrics and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands

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Miranda Van Eck Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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Menno Hoekstra Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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with fatigue, muscle weakness, loss of appetite, weight loss and abdominal pain and a predisposition to loss of consciousness under stress conditions ( Hannah-Shmouni & Stratakis 2018 ). Conversely, chronic glucocorticoid overexposure, for example in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0079
Volume/Issue:
Volume 242: Issue 2
Free access
Lesley A Hill Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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Tamara S Bodnar Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver

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Joanne Weinberg Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver

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Geoffrey L Hammond Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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from a variety of symptoms including chronic pain, fatigue, depression, hypotension and excess body weight ( Gagliardi et al. 2010 ), it remains to be determined how well they cope with severe, acute inflammation. To explore this, we have determined

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0047
Volume/Issue:
Volume 230: Issue 2
Free access
Karen Kar-Loen Chan Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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Thomas Ho-Yin Leung Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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David Wai Chan Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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Na Wei Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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Grace Tak-Yi Lau Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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Stephanie Si Liu Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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Michelle K-Y Siu Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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Hextan Yuen-Sheung Ngan Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, 6/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong

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ovarian clear cell adenocarcinoma cells. Apart from its potential use in tumor suppression, the use of selective ERβ agonist has also been investigated in different diseases. ERβ agonist alleviated the chronic inflammatory pain state and was suggested to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0500
Volume/Issue:
Volume 221: Issue 2
Free access