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Jun Yang Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, Monash University, Clayton, Victoria, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Discovery & Preclinical Domain, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Timothy J Cole Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Peter J Fuller Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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hypertension <40 years, the median duration of hypertension at the time of diagnosis of PA was 10.5 years (3.5–18 years) ( Alam et al. 2021 ). It is therefore not surprising that less than 0.1% of 1.1 million Canadian adults with hypertension ( Liu 2021 ) and

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Maria L Price Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Cameron D Ley Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Caroline M Gorvin Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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5-HT 2C R antagonist enhanced ghrelin-induced increases in food intake, and extended the duration of ghrelin’s orexigenic effect. - Administration of lorcaserin delayed ghrelin-induced effects on food intake. (Schellekens et al. 2015) DRD1

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Luba Sominsky School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia

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Christine L Jasoni School of Biomedical Sciences, Centre for Neuroendocrinology, Department of Anatomy, University of Otago, Dunedin, New Zealand

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Hannah R Twigg School of Biomedical Sciences, Centre for Neuroendocrinology, Department of Anatomy, University of Otago, Dunedin, New Zealand

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Sarah J Spencer School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia

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responsiveness, reproduction, thermoregulation, sleep circadian rhythms and others ( Fig. 1 ). For example, the neuropeptide Y (NPY)/agouti-related protein (AgRP)- and pro-opiomelanocortin (POMC)/cocaine- and amphetamine-regulated transcript (CART)- containing

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Fabio Arturo Iannotti Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Campania, Italy

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Vincenzo Di Marzo Director, Joint International Research Unit for the Chemical and Biomolecular Study of the Microbiome in Metabolic Health and Nutrition (JIRU-MicroMeNu) between the Consiglio Nazionale delle Ricerche (CNR, Institute of Biomolecular Chemistry) and Université Laval, Naples, Campania, Italy
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada

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acid amides, such as the sleep-inducing factor, oleamide, a FAAH substrate that was suggested to activate CB1 ( Leggett et al. 2004 ), and, like some unsaturated NAEs, to antagonise the transient receptor potential vanilloid type-2 (TRPV2) channel

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Nigel Turner Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Gregory J Cooney Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Edward W Kraegen Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Clinton R Bruce Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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administration of glucose and duration of fast before glucose administration influence the results of glucose tolerance tests ( Andrikopoulos et al . 2008 , McGuinness et al . 2009 ), and our recent studies suggest that changes in glucose tolerance may reflect

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Katie Wynne Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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Sarah Stanley Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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Barbara McGowan Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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Steve Bloom Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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& Schwartz 1994 ). Administration of CCK, to both humans and animals, has long been known to inhibit food intake by reducing meal size and duration ( Gibbs et al. 1973 , Kissileff et al. 1981 ), an effect which is enhanced by gastric distension

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