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Haijiang Wu Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

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Xinna Deng Departments of Oncology & Immunotherapy, Hebei General Hospital, Shijiazhuang, China

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Yonghong Shi Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

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Ye Su Mathew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
Departments of Medicine and Pathology, University of Western Ontario, London, Ontario, Canada

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Jinying Wei Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

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Huijun Duan Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

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wide range of transcription factors involved in cellular energy metabolism. By regulating the activities of these transcription factors, PGC-1α acts as a molecular switch for multiple cellular processes, including mitochondrial biogenesis and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0021
Volume/Issue:
Volume 229: Issue 3
Free access
O Gubbay Division of Reproductive and Developmental Sciences, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Medical Research Council Human Reproductive Sciences Unit, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9RG, UK
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S-830 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA

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M T Rae Division of Reproductive and Developmental Sciences, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Medical Research Council Human Reproductive Sciences Unit, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9RG, UK
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S-830 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA

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A S McNeilly Division of Reproductive and Developmental Sciences, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Medical Research Council Human Reproductive Sciences Unit, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9RG, UK
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S-830 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA

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F X Donadeu Division of Reproductive and Developmental Sciences, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Medical Research Council Human Reproductive Sciences Unit, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9RG, UK
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S-830 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA

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A J Zeleznik Division of Reproductive and Developmental Sciences, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Medical Research Council Human Reproductive Sciences Unit, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9RG, UK
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S-830 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA

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S G Hillier Division of Reproductive and Developmental Sciences, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Medical Research Council Human Reproductive Sciences Unit, Queen’s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9RG, UK
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S-830 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA

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leading to cAMP-dependent protein kinase A (PKA)-mediated phosphorylation of transcription factors, such as cAMP-response element (CRE) binding protein (CREB) and activating transcription factor-1 (ATF1) ( Carlone & Richards 1997 , Conti 2002

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06928
Volume/Issue:
Volume 191: Issue 1
Free access
David A Taylor-Fishwick Department of Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA

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Wenjing Shi Department of Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA

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Gary L Pittenger Department of Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA

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Aaron I Vinik Department of Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA

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signaling pathways including AP-1 and STAT, a number of predicted interaction sites for transcription factors associated with pancreas development. These include the homeo-domain transcription factor PDX-1, inactivation of which results in agenesis of the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06108
Volume/Issue:
Volume 188: Issue 3
Free access
Asmaà Fritah Institut National de la Santé et de la Recherche Médicale, U673, Hôpital Saint-Antoine, Université Pierre et Marie Curie (UPMC-Paris 6), Paris, France

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Gérard Redeuilh Institut National de la Santé et de la Recherche Médicale, U673, Hôpital Saint-Antoine, Université Pierre et Marie Curie (UPMC-Paris 6), Paris, France

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Michèle Sabbah Institut National de la Santé et de la Recherche Médicale, U673, Hôpital Saint-Antoine, Université Pierre et Marie Curie (UPMC-Paris 6), Paris, France

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sequence called the oestrogen response element (ERE), which is usually located upstream of the promoter and displays enhancer properties. For regulation of gene transcription, ER has to interact with basal transcription factors and RNA polymerase II ( Jacq

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07009
Volume/Issue:
Volume 191: Issue 3
Free access
Tracy Xiao Cui
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Roland Kwok Department of Molecular and Integrative Physiology, Departments of OB/GYN and Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0622, USA

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Jessica Schwartz
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) and an adjacent CCAAT/enhancer-binding protein (C/EBP) site, and an activator protein-1 (AP-1) site; these elements can be bound by cognate transcription factors to regulate c- fos transcription in response to GH ( Meyer et al . 1993 , 1994

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0169
Volume/Issue:
Volume 196: Issue 1
Free access
Abdullah Cim
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Greta J Sawyer
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Xiaohong Zhang
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Haibin Su
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Louise Collins
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Peter Jones Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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Michael Antoniou Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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Jean-Paul Reynes Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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Hans-Joachim Lipps Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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John W Fabre
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factor NeuroD1 avoided exocrine transdifferentiation ( Kojima et al . 2003 ). More recently, transdifferentiation to insulin-producing cells, without exocrine differentiation, has been achieved in mice with adenovirus delivery of multiple transcription

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0033
Volume/Issue:
Volume 214: Issue 3
Free access
T Taguchi Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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T Takao Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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Y Iwasaki Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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M Nishiyama Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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K Asaba Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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K Hashimoto Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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-atherosclerotic, and anti-aging effects ( Aoki et al. 2003 ). Some of these effects are thought to be mediated by its antioxidant properties via inhibition of nuclear factor-κB (NF-κB) ( Aragno et al. 2002 , Iwasaki et al. 2004 ), which is a transcription factor

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06418
Volume/Issue:
Volume 188: Issue 2
Free access
Won Bae Kim Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA

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Christopher J Lewis Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA

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Kelly D McCall Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA

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Ramiro Malgor Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA

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Aimee D Kohn Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA

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Randall T Moon Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA

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Leonard D Kohn Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA

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2004 ). β-Catenin, a transcription cofactor that acts together with T cell factor/lymphoid enhancing factor (TCF/LEF) to induce target gene expression ( Cadigan & Nusse 1997 ), is a structural adaptor protein linking cadherins to the actin cytoskeleton

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0025
Volume/Issue:
Volume 193: Issue 1
Free access
Kyriaki S Alatzoglou Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Daniel Kelberman Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Mehul T Dattani Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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primordium and the correct morphogenesis of the gland require the sequential temporal and spatial expression of a cascade of signalling molecules and transcription factors that will eventually dictate organ commitment, cell proliferation, patterning and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0447
Volume/Issue:
Volume 200: Issue 3
Free access
Jin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Yuhuan Liu Department of Gynecology and Obstetrics, Changhai Hospital, Naval Medical University, Shanghai, China

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Danying Zhang Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Dongxia Zhai Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Linyi Song Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Zailong Cai Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai, China

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Chaoqin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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deletion analysis and transcription factor-binding site analysis, GATA-binding factor 1 (GATA1) was identified as a transcription factor most relevant to the HSD3B2 gene expression after cells were incubated with baicalin. To further confirm these results

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0678
Volume/Issue:
Volume 240: Issue 3
Open access