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Henri Wallaschofski

introduced new insights into the pathology of diabetes as well as methods to predict disease onset and has revealed new biomarkers. Diabetes is the most common metabolic disease, and its complications have a significant economic impact on the health system

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Simon J Dunmore

The inexorable rise in obesity around the planet, particularly in developed countries but increasingly in the developing world, is accompanied by a parallel rise in co-morbid metabolic diseases including type 2 diabetes and vascular disease. Obesity

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S Andrikopoulos, C Farquharson, and M Haluzik

the traditional focus on experimental research, we encourage submissions from translational research areas, including studies in humans that specifically address the pathophysiological mechanisms of endocrine and metabolic diseases. The journals have

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Isabel Huang-Doran, Alison Sleigh, Justin J Rochford, Stephen O'Rahilly, and David B Savage

the relationship between obesity, insulin resistance and metabolic disease are incompletely understood, and the contributory genes are poorly defined. A powerful approach to this daunting problem – and one that is potentially applicable to any complex

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Filipe de Vadder and Gilles Mithieux

–brain axis. An increasingly popular field of investigation relates to the gut microbiota, residing mainly in the distal gut. The genetic composition of the gut microbiota is altered in obesity and metabolic diseases, which has led to the idea that the

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Ricardo Rodríguez-Calvo, Josefa Girona, Josep M Alegret, Alba Bosquet, Daiana Ibarretxe, and Lluís Masana

diagnosis ( Loehr et al . 2008 , Writing Group et al . 2010 ). Increasing evidence has highlighted the role of metabolic diseases as important risk factors for HF. In particular, obesity has been proposed as one of the main contributors to the onset and

Open access

Bettina Geidl-Flueck and Philipp A Gerber

a major trigger for the development of metabolic diseases. It is assumed, however, that factors other than an imbalanced energy intake and expenditure can influence metabolic health. A well-balanced macronutrient intake, characterized by a moderate

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Jocemara Patrícia Silva de Souza Parrela, Ingridys Regina Borkenhagen, Sarah Ramany Faria Salmeron, Thalyne Aparecida Leite Lima, Ginislene Dias Souza Miranda, Hercules de Oliveira Costermani, Camila Luiza Rodrigues dos Santos Ricken, Ester Vieira Alves, Rodrigo Mello Gomes, and Júlio Cezar de Oliveira

rapid weight gain are under a higher risk of adult diseases, regardless of their birth weight ( Ong 2007 ). This highlights a link between the rapid catch-up group in early life and the risk for the development of metabolic diseases associated with

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Greg M Kowalski, Michael J Kraakman, Shaun A Mason, Andrew J Murphy, and Clinton R Bruce

Introduction With the increasing prevalence of obesity and insulin resistance, the reliance on mouse models of metabolic disease has increased dramatically over the last decade ( Kowalski & Bruce 2014 ). The high-fat, high-sucrose-fed C57Bl/6

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Michael E Symonds, Mark Pope, Ian Bloor, James Law, Reham Alagal, and Helen Budge

of functional imaging There remains a debate as to whether the targeting of brown fat activation can be effective in preventing excess adiposity and/or related metabolic diseases such as diabetes ( Cypess & Kahn 2010 ). This is due in part to the