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I Klein
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O Esik
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V Homolya
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F Szeri
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A Varadi
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Medullary thyroid carcinoma (MTC) occurs usually in sporadic form, but about a quarter of the cases are hereditary and appear as part of one of the multiple endocrine neoplasia type 2 (MEN2) syndromes. Mutations in the RET protooncogene are known to be the cause of the MEN2A and familial medullary thyroid carcinoma (FMTC) syndromes in the majority of the families. Direct DNA testing allows prophylactic thyroidectomy to be offered to individuals carrying a mutation in the above codons, and in mutation-negative cases it reduces the yearly screening-related burden on family members at risk of the disease. By DNA sequencing and PCR-restriction fragment length polymorphisms, 65 MTC probands were examined for mutations in residues 609, 611, 618, 620 of exon 10, and in residues 634, 768, 804 of exons 11, 13, and 14 respectively of the RET protooncogene. In our study, mutations in the above codons were detected in all of the 14 clinically MEN2A and FMTC families. One of these mutations, TGC609 TCC has not been reported previously. Of the 14 probands with the mutation, 25 relatives also had the identified mutation and 18 relatives proved to be non-carriers. Among the 51 probands with clinically sporadic MTC, none was found to carry a mutation in the above positions even if indirect signs of MTC, pheochromocytoma or hyperparathyroidism could be detected in some families. The frequency of the TGC634AGC mutation is unexpectedly high in our samples, which can probably be attributed to a founder effect. We conclude that screening for mutations in these codons is effective in families fulfilling the strict clinical criteria of MEN2A or FMTC.

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F E Utama Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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M J LeBaron Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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L M Neilson Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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A S Sultan Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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A F Parlow Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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K-U Wagner Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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H Rui Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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10777D) were provided by Dr A F Parlow under the sponsorship of the National Hormone and Pituitary Program. Human epidermal growth factor (EGF) was purchased from Upstate Biotechnology (Lake Placid, NY, USA). Polyclonal rabbit anti-actin antisera and

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Research Acceleration Award, and US Department of Defence CDMRP FY19 Prostate Cancer Research Program – Idea Development Award (W81XWH2010331). The Translational Research Institute is supported by an Australian Government grant. The authors have no

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E Oliveira Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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E G Moura Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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A P Santos-Silva Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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A T S Fagundes Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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A S Rios Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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Y Abreu-Villaça Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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J F Nogueira Neto Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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M C F Passos Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute
Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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P C Lisboa Department of Physiological Sciences, Laboratory of Lipids, Department of Applied Nutrition, Roberto Alcantara Gomes Biology Institute

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has been named programing, which is defined as the phenomenon that putatively underlies relationships among nutritional experiences of early life and adult diseases ( Lucas 1994 , Barker 2003 , Moura & Passos 2005 , de Moura et al . 2008 ). Some

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Umberto Simeoni Division of Pediatrics & DOHaD Laboratory, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland

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Clive Osmond MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK

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Ricardo Garay Craven, Villemoisson-sur-Orge, France

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Christophe Buffat Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital de la Conception, Marseille, France

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Farid Boubred Division of Neonatology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Christophe Chagnaud Division of Radiology and Medical Imaging, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Elisabeth Jouve UPCET, Clinical Pharmacology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Christine Audebert UPCET, Clinical Pharmacology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Jean-Michel Antoine Danone Institute International, Paris, France

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Kent Thornburg Bob and Charlee Moore Institute for Nutrition and Wellness, Oregon Health & Science University, Portland, Oregon, USA

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for adult-onset disease is known as programming, but its biological underpinnings are not completely understood. The risk of coronary events has been found to be related to low weight at birth and during infancy, followed by a rapid increase in BMI

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Seokwon Jo Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Emilyn U Alejandro Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Washington, where she conducted type 1 diabetes research as an undergraduate McNair Scholar at Dr Ake Lernmark’s lab. She furthered her scientific passion by participating in a postbaccalaureate program at the National Cancer Institute at NIH under Dr Elise

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Simon Lecoutre Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Barbara Deracinois Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Christine Laborie Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Delphine Eberlé Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Céline Guinez Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Polina E Panchenko INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France

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Jean Lesage Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Didier Vieau Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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Claudine Junien INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France
UVSQ, Université Versailles-Saint-Quentin-en-Yvelines, Versailles, France

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Anne Gabory INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France

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Christophe Breton Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F59000 Lille, France

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‘developmental programming’ or ‘conditioning’ ( Barker 2004 , Hanson & Gluckman 2014 ), alterations of nutrient supply in the fetus or neonate result in long-term programming of individual body weight (BW) setpoint. Epidemiological studies initially showed that

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S C P Dutra
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E G Moura
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A L Rodrigues
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P C Lisboa
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I Bonomo
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F P Toste
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M C F Passos
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Introduction Experimental studies have shown that environmental changes, such as nutritional, endocrine disruptors, and other stressful events, occurring in a critical period early in life, permanently program the structure and

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Ana P Pinto Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Alisson L da Rocha Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Eike B Kohama Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Rafael C Gaspar Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Fernando M Simabuco Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Fabiani G Frantz Department of Clinical, Toxicological, and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Leandro P de Moura Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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José R Pauli Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Dennys E Cintra Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Eduardo R Ropelle Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Ellen C de Freitas School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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Adelino S R da Silva Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

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://doi.org/10.1055/s-0035-1555851 ) 10.1055/s-0035-1555851 Zinszner H Kuroda M Wang X Batchvarova N Lightfoot RT Remotti H Stevens JL Ron D 1998 CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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Rodrigo Martins Pereira Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Kellen Cristina da Cruz Rodrigues Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Chadi Pellegrini Anaruma Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Marcella Ramos Sant’Ana Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Thaís Dantis Pereira de Campos Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Rodrigo Stellzer Gaspar Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Raphael dos Santos Canciglieri Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Diego Gomes de Melo Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Rania A Mekary Department of Neurosurgery, Computational Neuroscience Outcomes Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Social and Administrative Sciences, School of Pharmacy, MCPHS University, Boston, Massachusetts, USA

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Adelino Sanchez Ramos da Silva School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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Dennys Esper Cintra Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Eduardo Rochete Ropelle Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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José Rodrigo Pauli Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Leandro Pereira de Moura Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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-Aldrich) for 25 min, washed and stained with eosin (5 min). The slices stained with oil red O were used to analyses of lipid droplets area and red stained area using ImageJ ( Schneider et al. 2012 ) program using the 40× image, in agreement with previous

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