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Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary

Shona Wood

Shona Wood Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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Andrew Loudon

Andrew Loudon Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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ES Ross AW Wilson D Plé H Mercer JG Ebling FJ Schuhler S Dupré SM 2006 Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-14-0141

Volume/Issue:: Volume 222: Issue 2

Open access

20 YEARS OF LEPTIN: Role of leptin in human reproductive disorders

Sharon H Chou

Sharon H Chou Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA

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Christos Mantzoros

Christos Mantzoros Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA
Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA

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Yildizhan B Kolusari A Adali E Bugdayci G 2011 Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome . Fertility and Sterility 96 246 – 250

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-14-0245

Volume/Issue:: Volume 223: Issue 1

Free access

Testosterone and glucose metabolism in men: current concepts and controversies

Mathis Grossmann

Mathis Grossmann Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia
Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia

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retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis . Diabetes 61 1072 – 1081 . ( doi:10.2337/db11-1136 ) McLachlan RI 2010 Certainly more guidelines than rules . Journal of Clinical

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-13-0393

Volume/Issue:: Volume 220: Issue 3

Free access

A STAR for the ages: a 30-year historical perspective of the role of transcription factors in the regulation of steroidogenic acute regulatory gene expression

Robert S Viger

Robert S Viger Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

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Marie France Bouchard

Marie France Bouchard Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada

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Jacques J Tremblay

Jacques J Tremblay Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

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JF 3rd & McAllister JM 2005 Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome . Journal of Clinical Endocrinology and Metabolism

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-24-0087

Volume/Issue:: Volume 263: Issue 2

Restricted access

Androgen and estrogen actions on male physical activity: a story beyond muscle

Ferran Jardí

Ferran Jardí Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Michaël R Laurent

Michaël R Laurent Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Vanessa Dubois

Vanessa Dubois Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Nari Kim

Nari Kim Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Rougin Khalil

Rougin Khalil Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Brigitte Decallonne

Brigitte Decallonne Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Dirk Vanderschueren

Dirk Vanderschueren Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Frank Claessens

Frank Claessens Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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://doi.org/10.1016/j.physbeh.2007.07.010 ) 10.1016/j.physbeh.2007.07.010 McInnes KJ Smith LB Hunger NI Saunders PTK Andrew R Walker BR 2012 Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-18-0125

Volume/Issue:: Volume 238: Issue 1

Free access

Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model

Weiliang Xia

Weiliang Xia Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Dolores D Mruk

Dolores D Mruk Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Will M Lee

Will M Lee Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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C Yan Cheng

C Yan Cheng Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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.9 Hepcidin antimicrobial peptide NM_012733 Rbp1 1.2 4.1 Retinol-binding protein 1 Proteases/ protease inhibitors NM_031531 Spin2c 1.5 26.0 Serine protease inhibitor NM_053819 Timp1 1.7 15.0 Tissue inhibitor of metalloproteinase 1 BF411331 Serpinb1a

Article Type:: Research Article

DOI:: https://doi.org/10.1677/JOE-06-0158

Volume/Issue:: Volume 192: Issue 3

Free access

An adipocentric perspective of pancreatic lipotoxicity in diabetes pathogenesis

Renata Risi

Renata Risi Department of Experimental Medicine, Sapienza University of Rome, Sapienza University of Rome, Rome, Italy
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK

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Antonio Vidal-Puig

Antonio Vidal-Puig University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
Cambridge University Nanjing Centre of Technology and Innovation, Nanjing, P. R. China
Centro de Investigacion Principe Felipe, Valencia, Spain

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Guillaume Bidault

Guillaume Bidault University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK

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and a lipid core composed of TAGs, cholesterol ester and retinol ester ( Welte & Gould 2017 ) that are detected in adult islet β cells ( Vernier et al. 2012 , Trevino et al. 2015 , Dai et al. 2016 ). LD formation starts as TAG accumulation

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-23-0313

Volume/Issue:: Volume 262: Issue 1

Open access

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Manuel D Gahete

Manuel D Gahete Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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David Rincón-Fernández

David Rincón-Fernández Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Alicia Villa-Osaba

Alicia Villa-Osaba Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Daniel Hormaechea-Agulla

Daniel Hormaechea-Agulla Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Alejandro Ibáñez-Costa

Alejandro Ibáñez-Costa Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Antonio J Martínez-Fuentes

Antonio J Martínez-Fuentes Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Francisco Gracia-Navarro

Francisco Gracia-Navarro Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Justo P Castaño

Justo P Castaño Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Raúl M Luque

Raúl M Luque Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Pedersen SB Moller N Jorgensen JO Jessen N 2013 Ghrelin- and GH-induced insulin resistance: no association with retinol-binding protein-4 . Endocrine Connections 2 96 – 103 . ( doi:10.1530/EC-13-0019 ) Volante M Allia E Gugliotta P Funaro A Broglio F

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-13-0391

Volume/Issue:: Volume 220: Issue 1

Free access

Is dehydroepiandrosterone a hormone?

F Labrie

F Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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V Luu-The

V Luu-The Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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A Bélanger

A Bélanger Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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S-X Lin

S-X Lin Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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J Simard

J Simard Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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G Pelletier

G Pelletier Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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C Labrie

C Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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-hydroxysteroid dehydrogenase activity of human recombinant 11-cis-retinol dehydrogenase. Biochimica et Biophysica Acta 1547 351 –358. Huang XF & Luu-The V 2001b Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase

Article Type:: Other

DOI:: https://doi.org/10.1677/joe.1.06264

Volume/Issue:: Volume 187: Issue 2

Free access

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

Mohammed Bensellam

Mohammed Bensellam Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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Jean-Christophe Jonas

Jean-Christophe Jonas Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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D Ross Laybutt

D Ross Laybutt Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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catalyses the oxidation of retinal to retinol using NAD + . It is also involved in other metabolic processes including amino acid metabolism and the metabolism of lipid peroxidation products ( Duan et al . 2016 ). Therefore, its upregulation in the islets