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Matthew W S Lim School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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Angela K Lucas-Herald School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK
Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK

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Avril Mason Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK

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Christian Delles School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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Paul J Connelly School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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secretion of gonadal sex steroids (oestrogen and testosterone) ( Flanagan & Manilall 2017 ). This is achieved and regulated via the activation of the anterior pituitary gonadotropin-releasing hormone (GnRH) receptors via its decapeptide ligand. Consequently

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0309
Volume/Issue:
Volume 261: Issue 1
Open access
Guy G T’Sjoen Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
Department of Endocrinology, Free University Amsterdam, 1007 MB, The Netherlands
Department of Hematology, University of Liège, 4000 Sart Tilman, Belgium

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Yves Beguin Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
Department of Endocrinology, Free University Amsterdam, 1007 MB, The Netherlands
Department of Hematology, University of Liège, 4000 Sart Tilman, Belgium

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Els Feyen Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
Department of Endocrinology, Free University Amsterdam, 1007 MB, The Netherlands
Department of Hematology, University of Liège, 4000 Sart Tilman, Belgium

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Robert Rubens Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
Department of Endocrinology, Free University Amsterdam, 1007 MB, The Netherlands
Department of Hematology, University of Liège, 4000 Sart Tilman, Belgium

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Jean-Marc Kaufman Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
Department of Endocrinology, Free University Amsterdam, 1007 MB, The Netherlands
Department of Hematology, University of Liège, 4000 Sart Tilman, Belgium

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Louis Gooren Department of Endocrinology, University Hospital Ghent, De Pintelaan 185, 9000 Gent, Belgium
Department of Endocrinology, Free University Amsterdam, 1007 MB, The Netherlands
Department of Hematology, University of Liège, 4000 Sart Tilman, Belgium

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, Krabbe et al. 1978 , Mooradian et al. 1987 , Krauss et al. 1991 ). Our study monitored the effects of sex steroids on Hb and the Hct in transsexuals undergoing cross-sex hormone administration, making use of a quantitative assay of bone marrow

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06112
Volume/Issue:
Volume 186: Issue 1
Free access
G Basini Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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S Bussolati Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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S E Santini Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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F Bianchi Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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M Careri Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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A Mangia Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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M Musci Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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F Grasselli Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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damaged tissues ( Fraser 2006 ). This observation suggests the potential for sex steroids to influence vessel growth. In particular, increased incidence in premenopausal females of diseases involving endothelial cell proliferation, such as Takayasu

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0258
Volume/Issue:
Volume 199: Issue 1
Free access
Campbell J L Harter School of Human Sciences, The University of Western Australia, Perth, Western Australia, Australia

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Georgia S Kavanagh School of Human Sciences, The University of Western Australia, Perth, Western Australia, Australia

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Jeremy T Smith School of Human Sciences, The University of Western Australia, Perth, Western Australia, Australia

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; the anterior pituitary, where GnRH pulses stimulate pituitary gonadotrophin (luteinising hormone (LH) and follicle-stimulating hormone (FSH)) secretion; and the gonads, which respond to the trophic actions of gonadotrophins by secreting sex steroids

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0108
Volume/Issue:
Volume 238: Issue 3
Free access
Scott M MacKenzie
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Deborah Dewar BHF Glasgow Cardiovascular Research Centre, Division of Clinical Neuroscience, Department of Neuropathology, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK

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William Stewart BHF Glasgow Cardiovascular Research Centre, Division of Clinical Neuroscience, Department of Neuropathology, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK

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Robert Fraser
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John M C Connell
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Eleanor Davies
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production of the sex steroids, which are implicated in certain brain functions. Experimental work on animals has shown that oestrogen has potent neuroprotective properties and is crucial to the development, maintenance and function of normal neural

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0427
Volume/Issue:
Volume 196: Issue 1
Free access
Carmen Corciulo Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Julia M Scheffler Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Piotr Humeniuk Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Alicia Del Carpio Pons Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Alexandra Stubelius Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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Ula Von Mentzer Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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Christina Drevinge Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Aidan Barrett Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Sofia Wüstenhagen Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Matti Poutanen Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland

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Claes Ohlsson Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden

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Marie K Lagerquist Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Ulrika Islander Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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-Zeinstra 2019 ). Epidemiological studies associate menopause with articular cartilage degeneration, OA severity, and unsuccessful joint replacement. The decline of sex steroids after menopause, in particular estrogens, has been investigated as responsible for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0032
Volume/Issue:
Volume 255: Issue 2
Open access
Milan Obradovic
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Predrag Bjelogrlic Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Manfredi Rizzo Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia
Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Niki Katsiki Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Mohamed Haidara Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia
Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Alan J Stewart Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Aleksandra Jovanovic
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Esma R Isenovic
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quadrants, inhibitory/reduction effect. The primary female sex steroid estradiol has long been recognized as an important hormone in a wide variety of physiological processes ( Knowlton & Lee 2012 ). Epidemiological and retrospective studies have

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0144
Volume/Issue:
Volume 218: Issue 3
Free access
Michelle P Marassi Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Rodrigo S Fortunato Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Alba C Matos da Silva Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Valmara S Pereira Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Denise P Carvalho Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Doris Rosenthal Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Vânia M Corrêa da Costa Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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, and others ( St Germain 1994 , Bianco et al. 2002 ). The prevalence of thyroid dysfunction is greater in women than in men. These disorders often appear concomitantly with changes in endogenous levels of sex steroids, in particular during

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06901
Volume/Issue:
Volume 192: Issue 1
Free access
Yuta Kasahara Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan

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Hiroshi Kishi Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan

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Ryo Yokomizo Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan

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Aikou Okamoto Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan

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Effect of ethanol on FSH-induced LHR expression and sex steroid hormone synthesis proteins in rat GCs. (A) GCs were cultured for 24 h and incubated with nothing (control), ethanol (200 mM), FSH (30 ng/mL), FSH plus ethanol (100 mM), or FSH plus ethanol

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0254
Volume/Issue:
Volume 257: Issue 1
Restricted access
Cassandra C Yap School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Michaela D Wharfe School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Peter J Mark School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Brendan J Waddell School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Jeremy T Smith School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Introduction Kisspeptin neurons are the afferent population that is critical for stimulation of gonadotropin-releasing hormone (GnRH) neurons, to drive the hypothalamic–pituitary–gonadal (HPG) axis. Gonadal sex steroids exert feedback actions

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0086
Volume/Issue:
Volume 229: Issue 3
Free access