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Wailan Shan, Shiyin Lu, Biqian Ou, Jia Feng, Zixian Wang, Huixian Li, Xiaohua Lu, and Yi Ma

endocrine disorders, the lowered T, and increased E2 in the HFD group could destroy the negative feedback loop of the hypothalamus-pituitary-testis (HPT) axis, thus reducing sperm production. In this study, HFD mice exhibited the lowest levels of T, FSH and

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Anne H van der Spek, Eric Fliers, and Anita Boelen

metabolism The regulation of plasma TH levels is conducted via a classic endocrine negative feedback loop involving the hypothalamic–pituitary–thyroid (HPT) axis. Hypophysiotropic neurons within the paraventricular nucleus of the hypothalamus produce