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Local control of thyroid hormone action: role of type 2 deiodinase

Deiodinases: the balance of thyroid hormone

Graham R Williams Molecular Endocrinology Group, Department of Medicine and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Commonwealth Building 7th Floor, Du Cane Road, London W12 0NN, UK

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J H Duncan Bassett Molecular Endocrinology Group, Department of Medicine and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Commonwealth Building 7th Floor, Du Cane Road, London W12 0NN, UK

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DIO2 in negative feedback control of the HPT axis occurs predominantly in thyrotrophs of the anterior pituitary gland. PVN, para-ventricular nucleus; TRH, thyrotropin-releasing hormone; DIO2, type 2 deiodinase enzyme; TRβ2, thyroid hormone receptor β2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0448
Volume/Issue:
Volume 209: Issue 3
Free access
Casey D Wright Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA

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Ryan J Orbus Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA

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Timothy R H Regnault Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA

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Russell V Anthony Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA
Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA

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placentomes ( Lacroix et al . 1996 ). This group also reported in situ hybridization of oGH mRNA in the syncytium and trophoblast layers of the placenta at 40 dGA ( Lacroix et al . 1999 ). The oGH receptor (oGHR) mRNA was initially identified in the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0481
Volume/Issue:
Volume 198: Issue 1
Free access
S C P Dutra
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E G Moura
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A L Rodrigues
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P C Lisboa
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I Bonomo
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F P Toste
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M C F Passos
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expression of OB-Rb receptors both at the thyroid and hypothalamus. The stimulatory effect of leptin on the thyroid function is well known, through its effects at the hypothalamic level, increasing TRH, or its direct effects on the thyroid gland ( Legradi et

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0366
Volume/Issue:
Volume 195: Issue 2
Free access
D C Ferguson Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA

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Z Caffall Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA

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M Hoenig Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA

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caused by hypothalamic–pituitary–TH resistance ( Edupuganti et al. 1997 ). Supporting this hypothesis is the observation that T 3 receptors are decreased in obesity and the negative feedback of circulating THs on TSH is decreased ( Burman et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0064
Volume/Issue:
Volume 194: Issue 2
Free access
Marc Schneeberger Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain

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Ramon Gomis Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain

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Marc Claret Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain

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functional inhibition of TH tonus and BAT thermogenesis ( Shi et al . 2013 ). Furthermore, NPY may also decrease pro-TRH transcription and proconvertase 2-mediated pro-TRH processing in the PVN through Y1/Y5 receptors ( Cyr et al . 2013 ). Taken together

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0398
Volume/Issue:
Volume 220: Issue 2
Free access
Pauline Campos College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK

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Jamie J Walker College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK
EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK
Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK

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Patrice Mollard IGF, University of Montpellier, CNRS, INSERM, Montpellier, France

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trigger large and rapid calcium (Ca 2+ ) influx through voltage-gated channels. AP firing can therefore be assessed by measuring changes in concentrations of intracellular Ca 2+ ( Yasuda et al. 2004 ). Similarly, activation of neurotransmitter receptors

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0028
Volume/Issue:
Volume 246: Issue 2
Open access
M T Rae
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D Niven
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A Ross
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T Forster
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R Lathe
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H O D Critchley
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P Ghazal
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S G Hillier
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contraceptive usage. HOSE cells are believed to be steroid responsive on the basis that exposure to ovarian steroids in vitro affects HOSE cell proliferation ( Karlan et al. 1995 ) and that they express nuclear hormone receptors, including oestrogen receptor

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05754
Volume/Issue:
Volume 183: Issue 1
Free access
Wenxia He Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Xiangyan Dai Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Xiaowen Chen Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Jiangyan He Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Zhan Yin Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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, the transcriptional levels of other neuropeptide signaling molecules, including Ssts and Sst receptors, Ghrh and Ghrh receptors, Npy receptors, thyrotropin-releasing hormone (Trh) and Trh receptors, corticotrophin-releasing hormone (Crh) and Crh

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0488
Volume/Issue:
Volume 221: Issue 3
Free access
G Tulipano
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A V Vergoni
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D Soldi
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E E Muller
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D Cocchi
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( Cocchi et al. 1999 ). Leptin also activates the hypothalamo–pituitary–thyroid axis through the thyrotropin-releasing hormone (TRH)-secreting neurons located in the paraventricular nucleus (PVN) ( Cusin et al. 2000 , Guo et al. 2004 , Huo et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05819
Volume/Issue:
Volume 183: Issue 2
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Jonathan J Nicholls Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Mary Jane Brassill Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Graham R Williams Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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J H Duncan Bassett Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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). Medial neurons of the paraventricular nucleus (PVN) in the hypothalamus synthesise and secrete thyrotrophin-releasing hormone (TRH), which in turn stimulates the synthesis and secretion of TSH from anterior pituitary thyrotrophs. TSH, acting on the TSH

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0059
Volume/Issue:
Volume 213: Issue 3
Free access