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Robert S Viger Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

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Marie France Bouchard Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada

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Jacques J Tremblay Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

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factors proposed to regulate STAR gene expression, and how this information has evolved over the last 30 years of active research. Figure 1 Proposed transcription factors implicated in STAR transcription. The PubMed biomedical literature

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Laura Fozzatti Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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María L Vélez Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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Ariel M Lucero Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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Juan P Nicola Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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Iván D Mascanfroni Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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Daniela R Macció Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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Claudia G Pellizas Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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Germán A Roth Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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Ana M Masini-Repiso Centro de Investigaciones en Bioquímica Clínica e Inmunología-(CIBICI) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

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to compare the RT-PCR products of the NIS gene with those of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene to determine their relative expression levels. PCR was performed in a 20 μl reaction volume containing 2 μl cDNA reaction, 0.5 μM of

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J. R. E. Davis
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Production of prolactin is very tissue-specific – the gene is present in all cells, but in the rat it is expressed only in the anterior pituitary gland, while in man it is also expressed at low levels in the decidualized endometrium. Much of the work on rat prolactin gene expression has been greatly facilitated by the availability of the rat pituitary tumour-derived GH cell line (including the GH1, GH3 and GH4 cell subclones) which produces both prolactin and growth hormone. In contrast, much less is so far known about the regulation of the human prolactin gene, due in part to the lack of readily available human pituitary tissue for in-vitro studies.

An increasing amount is known about hormonal and intracellular regulation of prolactin mRNA production, which has been reviewed elsewhere (Davis, Belayew & Sheppard, 1989). However, some of the most impressive and important recent advances have been

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K K Sidhu Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, West Smithfield, London EC1A 7BE, UK
Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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R C Fowkes Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, West Smithfield, London EC1A 7BE, UK
Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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R H Skelly Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, West Smithfield, London EC1A 7BE, UK
Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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J M Burrin Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, West Smithfield, London EC1A 7BE, UK
Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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promoter-driven insulin gene transcription. We have also used an adenoviral expression system to investigate the effects of GLP-1 on cAMP generation and insulin secretion. Materials and Methods Materials All

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Sharon Maor Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Doris Mayer Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Ronit I Yarden Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Adrian V Lee Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Rive Sarfstein Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Haim Werner Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Moshe Z Papa Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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-Johnson et al. 1995 ). Given the involvement of ERα in control of IGF-IR gene expression and IGF-I action, and in view of the fact that the transcriptional mechanisms involved in regulation of the IGF-IR gene by ERα have not yet been characterized, the

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A I Martín Department of Physiology, Faculty of Medicine, University Complutense of Madrid, 28040 Madrid, Spain

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M López-Menduiña Department of Physiology, Faculty of Medicine, University Complutense of Madrid, 28040 Madrid, Spain

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E Castillero Department of Physiology, Faculty of Medicine, University Complutense of Madrid, 28040 Madrid, Spain

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M Granado Department of Physiology, Faculty of Medicine, University Complutense of Madrid, 28040 Madrid, Spain

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M A Villanúa Department of Physiology, Faculty of Medicine, University Complutense of Madrid, 28040 Madrid, Spain

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A López-Calderón Department of Physiology, Faculty of Medicine, University Complutense of Madrid, 28040 Madrid, Spain

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expression in the liver ( Defalque et al . 1999 , Priego et al . 2003 a ). The inhibitory effect of LPS can be exerted directly on the hepatocyte, since LPS is able to decrease Igf1 gene expression in hepatocyte cultures ( Priego et al . 2006 ). We have

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Elena Grasselli DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Adriana Voci DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Ilaria Demori DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Laura Canesi DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Rita De Matteis DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Fernando Goglia DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Antonia Lanni DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Gabriella Gallo DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Laura Vergani DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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, PPARα is the master regulator of free fatty acid (FFA) oxidation systems, and decreases FFA efflux ( Reddy 2001 , Pyper et al . 2010 ). Also PPARδ induces expression of genes required for FFA oxidation ( Evans et al . 2004 , Pyper et al . 2010

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S Benvenuti
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P Luciani
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I Cellai
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C Deledda
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S Baglioni
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R Saccardi Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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S Urbani Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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F Francini Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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R Squecco Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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C Giuliani
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G B Vannelli Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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M Serio
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A Pinchera Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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A Peri
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Introduction Thyroid hormones (TH) play a fundamental role in fetal life, particularly in promoting brain development. TH affect the expression of several genes, which are related to cell migration (i.e. reelin, laminin, tenascin C), myelination (i

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Chandrika D Mahalingam Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Tanuka Datta Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Rashmi V Patil Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Jaclynn Kreider Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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R Daniel Bonfil Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Keith L Kirkwood Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Steven A Goldstein Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Abdul B Abou-Samra Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Nabanita S Datta Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Division of Endocrinology, Department of Orthopedic Surgery, Department of Urology and Pathology, Departments of Craniofacial Biology and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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Gapdh as fold change (mean± s.d .) with respect to PTH untreated differentiated cells from WT cultures. D, differentiated cells; a, P <0.001 versus D. Effects of Mkp1 deletion on osteoblast gene expression and PTH action The role of MKP1 in

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Yang Zhang Biology Department, State Key Laboratory of Biocontrol, The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences, School of Life Sciences

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Weimin Zhang Biology Department, State Key Laboratory of Biocontrol, The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences, School of Life Sciences
Biology Department, State Key Laboratory of Biocontrol, The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences, School of Life Sciences

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Huiyi Yang Biology Department, State Key Laboratory of Biocontrol, The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences, School of Life Sciences

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Wenliang Zhou Biology Department, State Key Laboratory of Biocontrol, The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences, School of Life Sciences

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Chaoqun Hu Biology Department, State Key Laboratory of Biocontrol, The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences, School of Life Sciences

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Lihong Zhang Biology Department, State Key Laboratory of Biocontrol, The Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences, School of Life Sciences

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a single copy of the CYP19 gene, and the tissue-specific expression was achieved by the use of tissue-specific promoters and alternative splicing of 5′untranslated exons ( Simpson 2003 ). However, two distinct CYP19 genes, namely cyp19a1a and

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