Search Results

-dependent transcription factors. By modulating the transcription of target genes in response to ligand, TRs play key physiological roles in the regulation of many aspects of development, growth and metabolism, including the regulation of mitochondrial activity ( Flamant

specifically targeted to epithelial cells. The major impediment for the development of mouse model of ovarian epithelial cancer is the lack of a specific promoter and oncogene that can direct gene expression to epithelial cells that lead to transformation of

the potential target of miR-143 affecting estradiol synthesis and granulosa cells proliferation in mouse granulosa cells, we used computational prediction algorithms, including miRanda and pictar. Among the putative target genes, KRAS plays important

membrane-spanning domains and constitute one of the largest and most diverse gene families in the mammalian genome ( Ostrom & Insel 2004 ). Some novel GPCRs do not have obvious endogenous ligands and are termed orphan receptors, a number of which appear to

identify the PDZ-domain coactivator of insulin gene expression Bridge-1 as an interaction partner for the nuclear receptor coactivator p300. The coactivator Bridge-1 is likely to regulate target gene transcription by participating in multiple protein

shown that Isl-1 regulates transcription of the insulin, gcg, and somatostatin genes ( Karlsson et al . 1990 , Vallejo et al . 1992 , Wang & Drucker 1995 , Peng et al . 2005 ). Targeted disruption of Isl-1 in mice results in an early arrest of

using SV Total RNA Isolation System (Promega). cDNA was synthesised using a High Capacity RNA-to-cDNA Kit and analysed using Power SYBR Green PCR Master Mix (Applied Biosystems). A group of Gc-target genes were selected from our previous microarray

from our own laboratory have found that MPR leads to decreases in the expression of the LXR-target gene, Cyp7a1 , the critical enzyme involved with cholesterol catabolism. The decrease in Cyp7a1 leads to hypercholesterolemia in male offspring by 4

of GCN5, a histone acetyltransferase that targets genes with a specific H3K9 and H4K8 sequence ( Kuo et al . 1996 , Maeng et al . 2009 , Guo et al . 2011 , Jin et al . 2011 ). Hypoxia increases reactive oxygen species (ROS) generation

-wide coverage (GWAS and MWAS, respectively). They pave the way for new discoveries including genetic determinants of TH action and regulation, identification of TH target genes or more in-depth characterization of molecular alterations related to TH effects