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Franca S Angeli Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Centrex 100, Philadelphia, Pennsylvania 19104, USA

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Richard P Shannon Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Centrex 100, Philadelphia, Pennsylvania 19104, USA

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worldwide epidemic, there is a growing demand for new treatments that not only control plasma glucose but also reduce macrovascular complications. Glucagon-like peptide 1 (GLP-1) is a peptide hormone synthesized in and secreted by enteroendocrine L cells in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0195
Volume/Issue:
Volume 221: Issue 1
Free access
Neerav Mullur The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Arianne Morissette The University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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Nadya M Morrow The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Erin E Mulvihill The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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administration ( McIntyre et al. 1965 ). The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) potentiate meal-stimulated insulin secretion through direct and indirect actions on islet β-cells. The first

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0046
Volume/Issue:
Volume 263: Issue 1
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Paige V Bauer Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, Canada
Department of Physiology, University of Toronto, Toronto, ON, Canada

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Frank A Duca Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, Canada

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. 2015 , Buse et al . 2016 ). Interestingly, this is not the only evidence for a therapeutic role of the gut in diabetes treatment. Over the past decade, incretin-based therapies including glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl

Article Type:
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DOI:
https://doi.org/10.1530/JOE-16-0056
Volume/Issue:
Volume 230: Issue 3
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Tianru Jin Departments of Medicine, Division of Cell and Molecular Biology, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Departments of Medicine, Division of Cell and Molecular Biology, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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cDNAs from these species further revealed that it encodes not only glucagon but also two glucagon-like peptide hormones, namely glucagon-like peptide-1 (GLP-1) and GLP-2 ( Lund et al . 1982 ). Glucagon is produced and released from the pancreatic α

Article Type:
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https://doi.org/10.1677/JOE-08-0085
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Volume 198: Issue 1
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Birgitte N Friedrichsen Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Nicole Neubauer Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Ying C Lee Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Vivian K Gram Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Niels Blume Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Jacob S Petersen Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Jens H Nielsen Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Annette Møldrup Novo Nordisk A/S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2.28, 2880 Bagsværd, Denmark
The University of Copenhagen, Department of Medical Biochemistry and Genetics, Copenhagen, Denmark

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Introduction The intestinal incretin hormones, glucagon-like peptide-1 (7–36) amide (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released in response to fat and carbohydrate ingestion. Both peptides act to augment

Article Type:
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DOI:
https://doi.org/10.1677/joe.1.06160
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Volume 188: Issue 3
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Bernardo Nuche-Berenguer Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Daniel Lozano Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Irene Gutiérrez-Rojas Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Paola Moreno Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Mariñoso Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Pedro Esbrit Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Villanueva-Peñacarrillo Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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obese subjects ( Zhao et al . 2008 , Buizert et al . 2009 ). It has been reported that the anti-diabetic peptides glucagon-like peptide 1 (GLP-1) and exendin 1–39 amide (Ex-4) show beneficial effects in reducing cholesterol and triglycerides in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0015
Volume/Issue:
Volume 209: Issue 2
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Sara Baldassano Laboratorio di Fisiologia Generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy

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Anna Lisa Bellanca Laboratorio di Fisiologia Generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy

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Rosa Serio Laboratorio di Fisiologia Generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy

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Flavia Mulè Laboratorio di Fisiologia Generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy

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. doi:10.1146/annurev.nutr.26.061505.111223 . Flint A Raben A Astrup B Holst JJ 1998 Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans . Journal of Clinical Investigation 101 515 – 520 . doi:10.1172/JCI990

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DOI:
https://doi.org/10.1530/JOE-12-0092
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Volume 213: Issue 3
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Ryan A Lafferty Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Peter R Flatt Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Victor A Gault Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Nigel Irwin Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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over a decade prior to another closely related, but now more widely renowned gut-derived hormone, glucagon-like peptide-1 (GLP-1) ( Müller et al. 2019 ). Like GLP-1, GIP is released into the circulation in response to ingestion of macronutrients, it

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0339
Volume/Issue:
Volume 262: Issue 2
Open access
S J Brandt Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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M Kleinert Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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M H Tschöp Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany
Division of Metabolic Diseases, Technische Universität, Munich, Germany

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T D Müller Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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). For example, following Roux-en-Y gastric bypass, gastric banding or sleeve gastronomy, there is an increase in the secretion of glucagon-like peptide 1 (GLP-1) ( Laferrere 2016 , Meek et al. 2016 , Clemmensen et al. 2017 ), which is known not

Article Type:
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DOI:
https://doi.org/10.1530/JOE-18-0264
Volume/Issue:
Volume 238: Issue 2
Open access
Shin-ya Ueda Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Takahiro Yoshikawa Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Yoshihiro Katsura Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Tatsuya Usui Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Hayato Nakao Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Shigeo Fujimoto Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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endocrine organs, including ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), and oxyntomodulin ( Huda et al . 2006 , Näslund & Hellstrom 2007 , Wren & Bloom 2007 ). While of these, ghrelin is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0500
Volume/Issue:
Volume 201: Issue 1
Free access