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Rosalba Senese
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Federica Cioffi Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

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Pieter de Lange
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Fernando Goglia Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

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Antonia Lanni
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included amelioration of memory and reduction in pain threshold ( Manni et al . 2013 ). T1AM's enhancing effect on learning renders this compound useful in the treatment of neurodegenerative diseases. 3,3′,5′-Triiodo- l -thyronine 3,3′,5′-T 3 (reverse T 3

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Petra Kaválková Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Miloš Mráz Third Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Pavel Trachta Third Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Jana Kloučková Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Anna Cinkajzlová Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Zdeňka Lacinová Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic
Third Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Denisa Haluzíková Department of Sports Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Marek Beneš Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Zuzana Vlasáková Department of Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Václav Burda Department of Cybernetics, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic

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Daniel Novák Department of Cybernetics, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic

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Tomáš Petr Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Libor Vítek Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic
Fourth Department of Internal Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

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Terezie Pelikánová Department of Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Martin Haluzík Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic
Department of Obesitology, Institute of Endocrinology, Prague, Czech Republic

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implantation was 18min (7–58min). No serious adverse events occurred during the study. Mild abdominal pain and nausea after implantation were experienced by 72% of patients during first 14days after implantation, 33% of patients during the first month and 10

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George Fink Florey Institute of Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building, Genetics Lane, Parkville, Victoria 3010, Australia

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models (e.g. Bless et al . 1997 , Good et al . 1999 , Kow et al . 2005 , Lee et al . 2008 , Galankin et al . 2010 , Rønnekleiv et al . 2012 , Babayan & Kramár 2013 ). In the human, oestrogen influences sensory, motor and pain responses in

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Maria Konstandi Department of Pharmacology, University of Ioannina, School of Health Sciences, Faculty of Medicine, Ioannina, Greece
National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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Christina E Andriopoulou Department of Pharmacology, University of Ioannina, School of Health Sciences, Faculty of Medicine, Ioannina, Greece

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Jie Cheng National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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Frank J Gonzalez National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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vaporization to 3.0–3.5%. This concentration of isoflurane provided deep anaesthesia, allowing the performance of surgical procedures without any clinical sign of pain or changes of macrohaemodynamic parameters (MAP and HR). This consisted of no movements of

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James M Evans School of Biosciences, Department of Hepatology and Gastroenterology, Cardiff University, Cardiff CF10 3AX, UK

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Laura S Morris School of Biosciences, Department of Hepatology and Gastroenterology, Cardiff University, Cardiff CF10 3AX, UK

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Julian R Marchesi School of Biosciences, Department of Hepatology and Gastroenterology, Cardiff University, Cardiff CF10 3AX, UK
School of Biosciences, Department of Hepatology and Gastroenterology, Cardiff University, Cardiff CF10 3AX, UK

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gastroenterological practice worldwide is irritable bowel syndrome (IBS), which is characterised by abnormal bowel function, bloating and abdominal pain or discomfort relieved by defaecation ( Spiller et al . 2007 ). IBS significantly affects quality of life ( Simren

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Louise Grahnemo Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Caroline Jochems Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden
Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Annica Andersson Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Cecilia Engdahl Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden
Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Claes Ohlsson Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Ulrika Islander Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Hans Carlsten Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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in the study mentioned were taken from epidemiological studies rather than being included as proper controls. In contrast, a retrospective study on postmenopausal women with lower back pain did not find a correlation between fractures or BMD and the

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Ulla Simanainen
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Yan Ru (Ellen) Gao
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Reena Desai
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Mark Jimenez
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Jennifer Spaliviero
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Janet R Keast ANZAC Research Institute, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales 2139, Australia

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David J Handelsman
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example, in nociceptive sensory neurons, many neurotrophic factors promote sensitisation, which underlies inflammatory and neuropathic pain states ( Pezet & McMahon 2006 ). Neurturin (NTN) is a member of the glial cell line-derived neurotrophic factor

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Ana B Ropero Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Pablo Juan-Picó Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Alex Rafacho Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Esther Fuentes Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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F Javier Bermúdez-Silva Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Enrique Roche Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Ivan Quesada Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Fernando Rodríguez de Fonseca Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Angel Nadal Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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50 – 58 . Suardiaz M Estivill-Torrus G Goicoechea C Bilbao A Rodriguez DF 2007 Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain . Pain 133 99 – 110 . Tordjman K Standley KN Bernal-Mizrachi C

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Linda Vignozzi Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Ilaria Cellai Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Raffaella Santi Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Letizia Lombardelli Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Annamaria Morelli Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Paolo Comeglio Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Sandra Filippi Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Federica Logiodice Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Marco Carini Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Gabriella Nesi Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Mauro Gacci Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Marie-Pierre Piccinni Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Luciano Adorini Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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Mario Maggi Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
Sexual Medicine and Andrology Unit, CIRMAR (Centro Interuniversitario di Ricerca sulle Basi Molecolari della Malattie della Riproduzione), Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Human Pathology and Oncology, Immunoallergology Unit, Department of Urology, Intercept Pharmaceuticals, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy

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, according to the standardized classification system of chronic prostatitis/chronic pelvic pain syndrome of the National Institutes of Health (NIH; Nickel et al . 2001 ). The following parameters were assessed: prevalent anatomical location (stromal

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Wei-Hua Shen Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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David W Boyle Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Paul Wisniowski Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Aashia Bade Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Edward A Liechty Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Introduction Initiation of mRNA translation is a complex process requiring several steps and more than a dozen eukaryotic initiation factor (eIFs) ( Pain 1996 ). It is proposed that the binding of mRNA to the 43S preinitiation

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