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Masafumi Amano
Masafumi Amano
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Shunsuke Moriyama
Shunsuke Moriyama
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Masayuki Iigo
Masayuki Iigo
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Shoji Kitamura
Shoji Kitamura
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Noriko Amiya
Noriko Amiya
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Kunio Yamamori
Kunio Yamamori
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Kazuyoshi Ukena
Kazuyoshi Ukena
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Kazuyoshi Tsutsui
Kazuyoshi Tsutsui
School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
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). GnIH-immunoreactive (ir) cell bodies and terminals were localized in the paraventricular nucleus and median eminence, respectively, indicating that GnIH acts directly on the pituitary ( Tsutsui et al. 2000 , Ubuka et al. 2003 , Ukena et al. 2003
Karen Francis
Karen Francis
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B Mary Lewis
B Mary Lewis
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Peter N Monk
Peter N Monk
Centre for Endocrine and Diabetes Sciences, Academic Neurology Unit, Cardiff University, Cardiff, CF14 4XN, UK
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Jack Ham
Jack Ham
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Introduction The hypothalamic–pituitary–adrenal (HPA) axis is a major regulator of immunity and inflammation via its secretion of glucocorticoids that suppress the immune activation of leukocytes and inhibit proinflammatory mediators. ACTH is the
Kotaro Horiguchi
Kotaro Horiguchi
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Tom Kouki
Tom Kouki
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Ken Fujiwara
Ken Fujiwara
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Motoshi Kikuchi
Motoshi Kikuchi
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Takashi Yashiro
Takashi Yashiro
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Introduction The anterior pituitary gland comprises five types of hormone-producing cells plus folliculo-stellate (FS) cells, which do not produce classical anterior pituitary hormones. FS cells have a star-like appearance ( Farquhar 1957 , Vila
M Victoria Recouvreux
M Victoria Recouvreux
Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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M Andrea Camilletti
M Andrea Camilletti
Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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Daniel B Rifkin
Daniel B Rifkin
Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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Graciela Díaz-Torga
Graciela Díaz-Torga
Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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Pituitary tumors Pituitary tumors are commonly benign, slow growing adenomas, and account for 10–15% of all intracranial neoplasms ( Farrell 2006 , Melmed 2015 ). The prevalence of these tumors is relatively high in the general population, with ∼77
M Theodoropoulou
M Theodoropoulou
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T Arzberger
T Arzberger
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Y Gruebler
Y Gruebler
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M L Jaffrain-Rea
M L Jaffrain-Rea
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J Schlegel
J Schlegel
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L Schaaf
L Schaaf
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E Petrangeli
E Petrangeli
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M Losa
M Losa
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G K Stalla
G K Stalla
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U Pagotto
U Pagotto
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Introduction Pituitary adenomas are benign tumors which account for 15% of all intracranial neoplasms. Despite the extensive studies performed to elucidate the molecular defects present in pituitary adenomas, their pathogenesis is
José E Sánchez-Criado
José E Sánchez-Criado
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
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Carmina Bellido
Carmina Bellido
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
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Rafaela Aguilar
Rafaela Aguilar
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
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José C Garrido-Gracia
José C Garrido-Gracia
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
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first exposure of the pituitary to GnRH ( de Koning et al. 1976 ). Progesterone receptor (PR) plays a key role in augmenting gonadotroph responsiveness to GnRH ( Waring & Turgeon 1992 , Turgeon & Waring 1994 ) and requires previous exposure of the
M Candolfi
M Candolfi
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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G Jaita
G Jaita
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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D Pisera
D Pisera
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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L Ferrari
L Ferrari
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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C Barcia
C Barcia
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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C Liu
C Liu
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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J Yu
J Yu
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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G Liu
G Liu
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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M G Castro
M G Castro
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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A Seilicovich
A Seilicovich
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
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Introduction Although most pituitary tumors are benign, aggressive local growth can occur. Altered pituitary hormone release often leads to serious clinical disorders, such as acromegaly, Cushing’s disease and sexual dysfunction
Kotaro Horiguchi
Kotaro Horiguchi
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Motoshi Kikuchi
Motoshi Kikuchi
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Kenji Kusumoto
Kenji Kusumoto
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Ken Fujiwara
Ken Fujiwara
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Tom Kouki
Tom Kouki
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Kotaro Kawanishi
Kotaro Kawanishi
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Takashi Yashiro
Takashi Yashiro
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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Introduction The anterior pituitary gland is composed of five types of hormone-producing cells and the folliculo-stellate cells (FS cells), which do not produce the classical anterior pituitary hormones. In vivo , these cells are surrounded by
Catherine Roche
Catherine Roche
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Alfredo J Zamora
Alfredo J Zamora
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David Taïeb
David Taïeb
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Esteban Lavaque
Esteban Lavaque
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Ramahefarizo Rasolonjanahary
Ramahefarizo Rasolonjanahary
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Henri Dufour
Henri Dufour
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Claude Bagnis
Claude Bagnis
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Alain Enjalbert
Alain Enjalbert
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Anne Barlier
Anne Barlier
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Introduction Pituitary adenomas account for 10–15% of all intracranial tumors. Ninety percent are represented by somatotroph adenomas (growth hormone (GH) secretors), clinically non-functioning adenomas (mainly gonadotroph) and
YM Keda
YM Keda
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IV Krjukova
IV Krjukova
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IA Ilovaiskaia
IA Ilovaiskaia
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MS Morozova
MS Morozova
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OV Fofanova
OV Fofanova
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MB Babarina
MB Babarina
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EI Marova
EI Marova
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YA Pankov
YA Pankov
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VI Kandror
VI Kandror
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Autoantibodies to cell surface antigens of human somatotropinoma (ASAS), human prolactinoma (ASAP) and rat adenohypophysis (ASARA) were assayed in the serum of patients with pituitary diseases associated with GH deficiency (GHD), such as pituitary dwarfism and primary empty sella syndrome (ESS), and in the serum of patients with hyperprolactinaemia of different etiologies: idiopathic hyperprolactinaemia, prolactinoma and ESS. The investigation was carried out with a cellular variant of an ELISA. Among children with GHD, the highest percentage of antibody-positive patients was found in the group with idiopathic isolated GHD (89% of ASAS(+) patients and 30% of ASARA(+) patients vs 33.3% and 0% respectively in the group with idiopathic combined pituitary hormone deficiency, and 33.3% and 9% in patients with pituitary hypoplasia associated with isolated GHD or combined pituitary hormone deficiency). Among hyperprolactinaemic patients, the highest ASAP and ASARA frequency was observed in patients with idiopathic hyperprolactinaemia (67.7% and 41.9% respectively) where it was twice as high as in the group of patients with prolactinoma. The proportion of ASAS(+) and ASARA(+) did not differ significantly between the groups of patients with ess with or without GHD. Similarly, there was no significant difference between the number of ESS ASAP(+) and ASARA(+) patients with or without hyperprolactinaemia. The data obtained suggested that autoimmune disorders may be primary, and responsible, at least in part, for pituitary dysfunction in the cases of idiopathic isolated GHD and idiopathic hyperprolactinaemia. At the same time, the autoimmune disorders in the patients with prolactinoma or ESS are probably secondary to the organic pituitary lesion and their significance in the development of the pituitary dysfunction is obscure.
