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Alberto Loizzo
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Santi M Spampinato Department of Therapeutic Research and Medicines Evaluation, Department of Pharmacology, Department of Pharmaceutical and Biomedical Sciences, Department of Psychiatry, Department of Psychology, Istituto Superiore di Sanita', via Regina Elena 299, 00161 Rome, Italy

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Gabriele Campana Department of Therapeutic Research and Medicines Evaluation, Department of Pharmacology, Department of Pharmaceutical and Biomedical Sciences, Department of Psychiatry, Department of Psychology, Istituto Superiore di Sanita', via Regina Elena 299, 00161 Rome, Italy

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Stefano Vella
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Andrea Fortuna
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Loredana Costa
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Anna Capasso Department of Therapeutic Research and Medicines Evaluation, Department of Pharmacology, Department of Pharmaceutical and Biomedical Sciences, Department of Psychiatry, Department of Psychology, Istituto Superiore di Sanita', via Regina Elena 299, 00161 Rome, Italy

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Palmiero Monteleone Department of Therapeutic Research and Medicines Evaluation, Department of Pharmacology, Department of Pharmaceutical and Biomedical Sciences, Department of Psychiatry, Department of Psychology, Istituto Superiore di Sanita', via Regina Elena 299, 00161 Rome, Italy

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Paolo Renzi Department of Therapeutic Research and Medicines Evaluation, Department of Pharmacology, Department of Pharmaceutical and Biomedical Sciences, Department of Psychiatry, Department of Psychology, Istituto Superiore di Sanita', via Regina Elena 299, 00161 Rome, Italy

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Stefano Loizzo
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(upward) peaks was averaged and evaluated. OPs consist of short (20–40 ms) bursts of high-frequency rhythmic oscillations, which are evoked in the retina, lateral geniculate nucleus, and cortical areas by light stimuli in man and animals. OPs are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0369
Volume/Issue:
Volume 215: Issue 3
Free access
J J Corrales Servicio de Endocrinología, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain
Servicio General de Citometría and Servicio de Endocrinología, Departamento de Medicina, Universidad de Salamanca, Spain

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M Almeida Servicio de Endocrinología, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain
Servicio General de Citometría and Servicio de Endocrinología, Departamento de Medicina, Universidad de Salamanca, Spain

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R Burgo Servicio de Endocrinología, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain
Servicio General de Citometría and Servicio de Endocrinología, Departamento de Medicina, Universidad de Salamanca, Spain

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M T Mories Servicio de Endocrinología, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain
Servicio General de Citometría and Servicio de Endocrinología, Departamento de Medicina, Universidad de Salamanca, Spain

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J M Miralles Servicio de Endocrinología, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain
Servicio General de Citometría and Servicio de Endocrinología, Departamento de Medicina, Universidad de Salamanca, Spain

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A Orfao Servicio de Endocrinología, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain
Servicio General de Citometría and Servicio de Endocrinología, Departamento de Medicina, Universidad de Salamanca, Spain

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). Here we report a prospective study on the short- and long-term effects of androgen-replacement therapy on the circulating inflammatory cellular compartment of the immune system in a group of type-2 diabetic men with partial androgen deficiency followed

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06779
Volume/Issue:
Volume 189: Issue 3
Free access
Nigel Turner Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Gregory J Cooney Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Edward W Kraegen Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Clinton R Bruce Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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into short chain (2–6 carbon atoms), medium chain (8–12 carbon atoms), long chain (14–18 carbon atoms) and very long chain (20–26 carbon atoms). The major types of FAs in the circulation and in the tissues of mammals are the long-chain and very

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0397
Volume/Issue:
Volume 220: Issue 2
Free access
J Cantley School of Medicine, University of Dundee, Dundee, United Kingdom of Great Britain and Northern Ireland

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D L Eizirik ULB Center for Diabetes Research, Université Libre de Bruxelles Faculté de Médecine, Bruxelles, Belgium

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E Latres JDRF International, New York, NY, USA

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C M Dayan Cardiff University School of Medicine, Cardiff, United Kingdom of Great Britain and Northern Ireland

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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022
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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022

years. Donors with young-onset (age <10 years) and short duration (<2 years); those with long duration (>35 years); and those with late-onset (age >30 years) receive less attention due to limited access. The need to study ‘all’ groups is highlighted by

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0082
Volume/Issue:
Volume 259: Issue 1
Open access
I M McGonnell Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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R C Fowkes Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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information on husbandry, which can also be accessed via ZFIN homepage http://zfin.org/cgi-bin/webdriver?MIval=aa-ZDB_home.apg . Their life span is approximately 3 years, but they have short generation times (3 months) and are reproductively capable for about

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06683
Volume/Issue:
Volume 189: Issue 3
Free access
Stefan Groeneweg Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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Robin P Peeters Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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Theo J Visser Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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W Edward Visser Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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-life of TA 3 is ~6 h and, thus, is markedly shorter than the half-life of T 3 (~24 h) ( Table 1 ). Peak levels occur within 40 min after oral administration and higher peak levels are achieved upon intravenous administration ( Menegay et al. 1989

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0113
Volume/Issue:
Volume 234: Issue 2
Free access
Wanpitak Pongkan Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Hiranya Pintana Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Sivaporn Sivasinprasasn Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Thidarat Jaiwongkam Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Siriporn C Chattipakorn Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Department of Oral Biology and Diagnostic Science, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand

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Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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along the short and long axes of the heart. Signals from an M-mode ECG at the level of the papillary muscles were recorded. Parameters obtained included right ventricular dimension during diastole, interventricular septum during systole and diastole, LV

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0002
Volume/Issue:
Volume 229: Issue 3
Free access
Ricardo Rodríguez-Calvo Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Josefa Girona Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Josep M Alegret Department of Cardiology, Cardiovascular Research Group, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Reus, Spain

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Alba Bosquet Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Daiana Ibarretxe Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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Lluís Masana Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, ‘Sant Joan’ University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain

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using neutralising antibodies as well as improving insulin sensitivity and glucose homeostasis ( Cao et al . 2013 , Miao et al . 2015 ). Similar effects were found by directly targeting FABP4 expression with short-hairpin RNAs (shRNAs) in adipose

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0031
Volume/Issue:
Volume 233: Issue 3
Free access
Charles A Ducsay
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Dean A Myers Center for Perinatal Biology, Department of Obstetrics and Gynecology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA

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composed of an intricate arrangement of steroidogenic cells as well as other non-steroidogenic components such as macrophages, endothelial cells, fibroblasts, and neuronal cells ( Mohn et al . 2005 ). The short half life of NO dictates that the site and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0034
Volume/Issue:
Volume 210: Issue 3
Free access
Ying Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China
Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Nan Meng Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haili Bao Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Yufei Jiang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Ningjie Yang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Kejia Wu Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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Jinxiang Wu Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haibin Wang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Shuangbo Kong Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Yuanzhen Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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clock system exists to adapt to environmental signals such as hormonal dynamics, light–dark cycles, feeding and fasting, chronothermal signals or sleep–wake cycles ( Papazyan et al. 2016 ). The rhythm pacemaker is generated within the suprachiasmatic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0284
Volume/Issue:
Volume 243: Issue 3
Restricted access