neurons in normally developed wild-type animals is sufficient to alter feeding and weight gain. In the present study, we used AAV vector-mediated RNA interference (RNAi) to suppress endogenous MC4R expression specifically in the PVN of the adult rat. Our
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Jacob C Garza, Chung Sub Kim, Jing Liu, Wei Zhang, and Xin-Yun Lu
Aline Cordeiro, Luana Lopes de Souza, Lorraine Soares Oliveira, Larissa Costa Faustino, Letícia Aragão Santiago, Flavia Fonseca Bloise, Tania Maria Ortiga-Carvalho, Norma Aparecida dos Santos Almeida, and Carmen Cabanelas Pazos-Moura
13% respectively ( Fig. 3 A, P <0.0001 vs free-feeding controls). Euthyroid-restricted mice exhibited no alteration in liver SIRT1 content in relation to euthyroid free-fed mice. As expected, liver and BAT SIRT1 expression was decreased in
Samantha M Solon-Biet, Sarah J Mitchell, Rafael de Cabo, David Raubenheimer, David G Le Couteur, and Stephen J Simpson
health and lifespan, it is important to note that other dietary regimens such as intermittent fasting and time-restricted feeding, also have beneficial effects in both mice and humans ( Mattson et al . 2014 , Fontana & Partridge 2015 ). The fact that
Yanbin Zheng, Wenshuo Zhang, Elisha Pendleton, Sanhua Leng, Jiong Wu, Ridong Chen, and Xiao Jian Sun
test (ITT) in the four experimental groups following 20 weeks of ad libitum or restricted (CR) feeding. After an overnight fast (16 h), rats were injected i.p. with 1.5 U/kg insulin. Blood glucose was assayed from the tail vein at indicated times
Tatiane da Silva Faria, Flávia de Bittencourt Brasil, Francisco J B Sampaio, and Cristiane da Fonte Ramos
. (2006) showed similar results. Based on those papers, we decided to analyze the effects of malnutrition only during the lactation time. The goal of this study was to evaluate whether maternal malnutrition during lactation alters folliculogenesis, the
Laura D Brown
. 1993 , 2010 ), glucose intolerance ( Hales et al . 1991 , Phipps et al . 1993 , McKeigue et al . 1998 ), and type 2 diabetes ( Curhan et al . 1996 , Rich-Edwards et al . 1999 ) later in life. Small for gestational age (SGA) status at the time
Nathanael J Yates, Dijana Tesic, Kirk W Feindel, Jeremy T Smith, Michael W Clarke, Celeste Wale, Rachael C Crew, Michaela D Wharfe, Andrew J O Whitehouse, and Caitlin S Wyrwoll
necessitate marked changes in the maternal brain to facilitate offspring care ( Bridges 2016 ). In rats, the time spent licking and grooming pups has a potent effect on epigenetic modifications and neuroendocrinology in the offspring brain, which result in
Takeshi Iwasa, Toshiya Matsuzaki, Masahiro Murakami, Riyo Kinouchi, Ganbat Gereltsetseg, Shinobu Fujisawa, Akira Kuwahara, Toshiyuki Yasui, and Minoru Irahara
, and the anorectic effects of leptin on appetite and feeding behaviors are acquired during the same period in mice and rats ( Mistry et al . 1999 , Carlo et al . 2007 ). Similarly, the adrenal response to FD is established during the neonatal period
Bernard Beck and Sébastien Richy
liver, whereas proteins are considered to supply body-building elements. All three of these macronutrients can modulate feeding behavior in a manner that is mainly dependent upon their physical form, type, and quantity in the ingested diet ( Sclafani
Jocemara Patrícia Silva de Souza Parrela, Ingridys Regina Borkenhagen, Sarah Ramany Faria Salmeron, Thalyne Aparecida Leite Lima, Ginislene Dias Souza Miranda, Hercules de Oliveira Costermani, Camila Luiza Rodrigues dos Santos Ricken, Ester Vieira Alves, Rodrigo Mello Gomes, and Júlio Cezar de Oliveira
dexamethasone-exposed and undernourished intrauterine growth restricted rats . PLoS ONE 7 e50131. ( https://doi.org/10.1371/journal.pone.0050131 ) 23166830 Spanswick DC Simonds SE Cowley MA 2012 Transmitter time: synaptic plasticity and metabolic
