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Elizabeth K Fletcher, Monica Kanki, James Morgan, David W Ray, Lea M Delbridge, Peter J Fuller, Colin D Clyne, and Morag J Young

Introduction The mineralocorticoid receptor (MR) is a ligand-activated transcription factor best known for regulating sodium/potassium and water in the kidney in response to aldosterone ( Fuller & Young 2005 ). The MR has equivalent high

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Eliane Correa-de-Santana, Bianca Fröhlich, Marta Labeur, Marcelo Páez-Pereda, Marily Theodoropoulou, Jose Luis Monteserin, Ulrich Renner, and Günter K Stalla

transcription factor important for mediating the inflammatory response, tumorigenesis and anti-apoptotic effects on cells. In addition to its ability to form complexes to itself and other STATs there are several reports showing that STAT3 and NFKB interact with

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Sinead N Kelly, T Joseph McKenna, and Leonie S Young

enzymes is controlled, at least in part, by ACTH and angiotensin II (AII), signalling through specific transcription factors such as steroidogenic factor-1 (SF-1) and nur77. We have previously demonstrated that nur77 may preferentially regulate steroid

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Mei-Fway Iu, Hiroshi Kaji, Hideaki Sowa, Junko Naito, Toshitsugu Sugimoto, and Kazuo Chihara

expression and transcription factor CBFa1 on bone cells by glucocorticoid. Journal of Biological Chemistry 273 4892 –4896. Chipuk JE , Cornelius SC, Pultz NJ, Jorgensen JS, Bonham MJ, Kim SJ & Danielpour D 2002 The androgen

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Almas R Juma, Pauliina E Damdimopoulou, Sylvia V H Grommen, Wim J M Van de Ven, and Bert De Groef

Introduction The transcription factor pleomorphic adenoma gene 1 (PLAG1) was first discovered via positional cloning when researchers were studying pleomorphic adenomas of the salivary glands ( Kas et al . 1997 ). Its role in various types of

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Ying-Ying Tsai, William E Rainey, and Wendy B Bollag

absent steroid hormone production and enlarged adrenal glands. Transcription factors, such as cAMP response element-binding protein (CREB), steroidogenic factor 1 (SF-1) and adrenal hypoplasia critical region on chromosome X gene 1 (DAX-1 or NR0B1), may

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Georg Homuth, Alexander Teumer, Uwe Völker, and Matthias Nauck

beginning, disease-relevant phenotypes were of particular interest in GWAS. However, the individual susceptibility for a given disease is only partially determined by genetic factors, and environmental influences are also of great importance, as are the

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C Giuliani, M Saji, I Bucci, G Fiore, M Liberatore, D S Singer, F Monaco, L D Kohn, and G Napolitano

regulation and identified the transcription factors and the cis -elements on the 5′-flanking regions of the class I gene involved ( Saji et al. 1992 a , 1992 b , 1997 , Giuliani et al. 1995 , Taniguchi et al. 1998 , Giuliani et al. 2000

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R L Moore, Y Dai, and D V Faller

transcription factors ( Tsai & Omalley 1994 , Mangelsdorf et al . 1995 , Aoyagi & Archer 2008 ). Steroid hormone receptors play essential roles in numerous biological processes, such as homeostasis, metabolism, cell growth, and development ( Tsai & Omalley

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Ralf Baumeister, Elke Schaffitzel, and Maren Hertweck

negatively regulate the FOXO transcription factor DAF-16. Inhibition of the daf-2 receptor gene expression/activity or other genes in the insulin/IGF pathway can have three effects. (A) Early developmental downregulation, which affects many biological