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Wenqi Chen Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Siyu Lu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Chengshun Yang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Na Li Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xuemei Chen Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Junlin He Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xueqing Liu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yubin Ding Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Chao Tong Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chuan Peng Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chen Zhang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Yan Su Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yingxiong Wang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Rufei Gao Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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control group. As we know, VEGF is critical for angiogenesis, and its role in promoting new blood vessel growth has been extensively investigated ( Hicklin & Ellis 2005 ). It is reported that VEGFA plays a role in VEGF-induced vascular permeability and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0127
Volume/Issue:
Volume 243: Issue 2
Restricted access
S Takai Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan

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Y Hanai Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan

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R Matsushima-Nishiwaki Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan

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C Minamitani Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan

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T Otsuka Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan

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H Tokuda Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan

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O Kozawa Department of Pharmacology, Department of Clinical Laboratory, Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan

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that FGF-2 induces the activation of p70 S6 kinase in osteoblast-like MC3T3-E1 cells, and the activated p70 S6 kinase plays an inhibitory role in the FGF-2-stimulated release of vascular endothelial growth factor (VEGF) through upregulation of stress

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0560
Volume/Issue:
Volume 197: Issue 1
Free access
Rhonda D Prisby Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA

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, immunohistochemical expression of vascular endothelial cell growth factor (VEGF) in bone, and bone perfusion and (2) increased the area of sinusoidal capillaries and marrow fat cell area ( Laroche et al. 1996 , Griffith et al. 2010 , Ding et al. 2011 ). The

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0666
Volume/Issue:
Volume 235: Issue 3
Free access
Zhenguang Zhang University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Agnes E Coutinho University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tak Yung Man University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tiina M J Kipari Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Patrick W F Hadoke University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Donald M Salter Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Jonathan R Seckl University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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downstream of vascular endothelial growth factor (VEGF)-α ( Fantin et al . 2010 ). Our finding of unchanged expression of Vegfa in Hsd11b1 MKO compared to control mice (also unchanged in global 11β-HSD1-deficient mice in a model of myocardial infarction

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0223
Volume/Issue:
Volume 234: Issue 3
Open access
Karolina Bäck Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden

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Rakibul Islam Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden

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Git S Johansson Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden

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Simona I Chisalita Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden

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Hans J Arnqvist Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden

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Instruments AB (CiAB), Sollentuna, Sweden) and the radioactivity was measured. Data were expressed as percent of radioactivity in untreated control cells. VEGF-165 (R&D Systems) was used as a positive control. Glucose accumulation HMVEC-Cs, around 100 000

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0261
Volume/Issue:
Volume 215: Issue 1
Free access
Vicki E Smith School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK

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Jayne A Franklyn School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK

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Christopher J McCabe School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK

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VEGF-mediated tumour neoangiogenesis. Human-specific siRNA allowed knock-down of one copy of PBF in Tc1 endothelial cells, which restored VEGF-mediated microvessel sprouting from previously unresponsive aortic rings to VEGF-treated wild-type levels

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0064
Volume/Issue:
Volume 210: Issue 2
Free access
Takumi Takeuchi Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Motofumi Suzuki Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Jimpei Kumagai Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Toshiyuki Kamijo Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Masato Sakai Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Tadaichi Kitamura Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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and paraffin-embedded sections (for dermatopontin, collagen 1, and vascular endothelial growth factor (VEGF) were blocked with 5% sheep normal serum and hybridized at room temperature for 30 min with 1:100 diluted primary antibodies (anti-human FGF-2

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06619
Volume/Issue:
Volume 190: Issue 2
Free access
Xiaoyi Ma Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Fei Gao Department of Orthopedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Qi Chen Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiuping Xuan Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Ying Wang Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Hongjun Deng Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Fengying Yang Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Li Yuan Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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responses and oxidative stress ( Shi et al . 2018 ), thus positively regulating beta-cell function and insulin release ( Yuan et al . 2014 , Brar et al . 2017 ). In our previous studies, A1–7 was found to improve vascular endothelial growth factor (VEGF

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0471
Volume/Issue:
Volume 246: Issue 3
Restricted access
B Shan
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C Schaaf
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A Schmidt
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K Lucia
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M Buchfelder Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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M Losa Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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D Kuhlen Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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J Kreutzer Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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M J Perone Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany
Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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E Arzt Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany
Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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G K Stalla
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U Renner
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is vascular endothelial growth factor A (VEGFA), which stimulates vessel growth predominantly through VEGF receptor type 2 (VEGFR2; Ferrara 2004 , Carmeliet 2005 ). We and others have previously shown that curcumin has anti-proliferative and pro

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0207
Volume/Issue:
Volume 214: Issue 3
Free access
Shannon M Gifford Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Fu-Xian Yi Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ian M Bird Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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/ml vascular endothelial growth factor (VEGF) for 8 or 19 min as appropriate. The reaction was stopped with the addition of ice-cold PBS (pH 7.4). The dishes were rinsed three times with PBS, the PBS was completely removed and the dishes were snap frozen in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06773
Volume/Issue:
Volume 190: Issue 2
Free access