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Maria H M Lima Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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Lílian C Souza Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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Luciana C Caperuto Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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Estela Bevilacqua Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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Alessandra L Gasparetti Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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Ricardo Zanuto Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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Mario J A Saad Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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Carla R O Carvalho Department of Physiology and Biophysics and
Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil

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insulin-like growth factor (IGF) receptor ( Willis & Franks 1995 , Nestler et al. 1998 ). We previously demonstrated a new intracellular pathway for LH/ hCG, showing that there is a positive crosstalk between insulin and the LH/hCG signaling pathway at

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Colin Farquharson Bone Biology Group, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK

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Katherine Staines Bone Biology Group, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK

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terminally differentiated osteoblast) does not live in isolation or in a vacuum and there is much crosstalk and communication between them and also with their collagenous-rich extracellular matrix. Together, these cellular activities and matrix interactions

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Raquel Barbuio Department of Internal Medicine and Gastrocentro, State University of Campinas, Campinas, SP 13083–970, Brazil

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Marciane Milanski Department of Internal Medicine and Gastrocentro, State University of Campinas, Campinas, SP 13083–970, Brazil

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Manoel B Bertolo Department of Internal Medicine and Gastrocentro, State University of Campinas, Campinas, SP 13083–970, Brazil

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Mário J Saad Department of Internal Medicine and Gastrocentro, State University of Campinas, Campinas, SP 13083–970, Brazil

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Lício A Velloso Department of Internal Medicine and Gastrocentro, State University of Campinas, Campinas, SP 13083–970, Brazil

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IR, IRS1, and IRS-2 ( Paz et al. 1997 , Hirosumi et al. 2002 , Araujo et al. 2005 ). The JAK2/STAT3 is a non-classical target of insulin signaling ( Saad et al. 1996 ) that participates in the crosstalk of the insulin signaling with several

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Ji-Eun Kim Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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Seung Eun Song Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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Yong-Woon Kim Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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Jong-Yeon Kim Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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Sung-Chul Park Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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Yoon-Ki Park Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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Suk-Hwan Baek Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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In Kyu Lee Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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So-Young Park Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea

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three samples were used. * P <0.05 versus control. Crosstalk between cAMP/PKA and AMPK pathways Crosstalk between cAMP/PKA and AMPK pathways was investigated, since both of these pathways mediate the inhibitory effect of adiponectin on palmitate

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Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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epithelial cell proliferation, change in the expression of genes encoding factors involved in stromal–epithelial cross-talk and a significant increase in the number of uterine glands in samples recovered on day 7 of treatment ( Simitsidellis et al. 2016

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Clara Lefranc INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France

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Malou Friederich-Persson Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Roberto Palacios-Ramirez INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France

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Aurelie Nguyen Dinh Cat INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France

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). In obese insulin-resistant patients, AMPK activity in adipose tissue is decreased ( Xu et al. 2012 ). Crosstalk between AMPK and RAAS has been demonstrated in kidney and in cardiomyocytes ( Stuck et al. 2008 , Hernández et al. 2014 , Yang

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Banrida Wahlang Department of Medicine, School of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Louisville, Louisville, Kentucky, USA
UofL Superfund Research Center, University of Louisville, Louisville, Kentucky, USA
The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, Kentucky, USA

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( Wahlang et al. 2019 a ). While their major role is xenobiotic detoxification, these receptors also play distinct roles in hepatic energy metabolism and inflammation through receptor–receptor crosstalk ( Cave et al. 2016 ). Interactions with endobiotic

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Jae Woo Jung Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea

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Chihoon Ahn Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea

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Sun Young Shim Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea

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Peter C Gray Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea

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Witek Kwiatkowski Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea
Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea

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Senyon Choe Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea
Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea

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coexistence in some tissues such as perinatal sensory neuron target tissues ( Hall et al . 2002 ) and pituitary suggests some crosstalk and possible synergy between the two pathways. Indeed, BMP2 is involved in pituitary development ( Ericson et al . 1998

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Tomoko Miyoshi
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Fumio Otsuka
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Hiroyuki Otani
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Kenichi Inagaki
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Junko Goto
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Misuzu Yamashita
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Toshio Ogura
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Yasumasa Iwasaki Department of Medicine and Clinical Science, Department of Endocrinology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hirofumi Makino
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-4 promotes pituitary prolactinoma pathogenesis through crosstalk between the BMP-4-mediated Smads and the estrogen receptor ( Paez-Pereda et al . 2003 ). BMP-4 also inhibits corticotropic pathogenesis and Cushing's disease in adult pituitary tumor

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Masaya Takeda Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Fumio Otsuka Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hiroyuki Otani Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Kenichi Inagaki Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Tomoko Miyoshi Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Jiro Suzuki Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Yukari Mimura Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Toshio Ogura Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hirofumi Makino Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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pituitary gonadotrope. For instance, BMP-4 promotes pituitary prolactinoma pathogenesis through a Smad–estrogen receptor crosstalk ( Paez-Pereda et al. 2003 ), whereas BMP-4 inhibits corticotropic pathogenesis and Cushing’s disease in adult pituitary tumor

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