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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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Department of Cellular and Development Biology, Institute of Biomedical Sciences, University of Sao Paulo (USP),
Department of Nursing and
Department of Internal Medicine, Medical Sciences Faculty, University of Campinas (UNICAMP), Brazil
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insulin-like growth factor (IGF) receptor ( Willis & Franks 1995 , Nestler et al. 1998 ). We previously demonstrated a new intracellular pathway for LH/ hCG, showing that there is a positive crosstalk between insulin and the LH/hCG signaling pathway at
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terminally differentiated osteoblast) does not live in isolation or in a vacuum and there is much crosstalk and communication between them and also with their collagenous-rich extracellular matrix. Together, these cellular activities and matrix interactions
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IR, IRS1, and IRS-2 ( Paz et al. 1997 , Hirosumi et al. 2002 , Araujo et al. 2005 ). The JAK2/STAT3 is a non-classical target of insulin signaling ( Saad et al. 1996 ) that participates in the crosstalk of the insulin signaling with several
Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
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Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
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Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
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Department of Physiology, Aging-associated Vascular Disease Research Center, Department of Obstetrics and Gynecology, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, South Korea
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three samples were used. * P <0.05 versus control. Crosstalk between cAMP/PKA and AMPK pathways Crosstalk between cAMP/PKA and AMPK pathways was investigated, since both of these pathways mediate the inhibitory effect of adiponectin on palmitate
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epithelial cell proliferation, change in the expression of genes encoding factors involved in stromal–epithelial cross-talk and a significant increase in the number of uterine glands in samples recovered on day 7 of treatment ( Simitsidellis et al. 2016
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). In obese insulin-resistant patients, AMPK activity in adipose tissue is decreased ( Xu et al. 2012 ). Crosstalk between AMPK and RAAS has been demonstrated in kidney and in cardiomyocytes ( Stuck et al. 2008 , Hernández et al. 2014 , Yang
UofL Superfund Research Center, University of Louisville, Louisville, Kentucky, USA
The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, Kentucky, USA
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( Wahlang et al. 2019 a ). While their major role is xenobiotic detoxification, these receptors also play distinct roles in hepatic energy metabolism and inflammation through receptor–receptor crosstalk ( Cave et al. 2016 ). Interactions with endobiotic
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Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea
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Joint Center for Biosciences, Structural Biology Laboratory, Clayton Foundation Laboratories for Peptide Biology, Songdo Global University Campus, 187 Songdo‐dong, Yeonsu‐gu, Incheon 406-840, Korea
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coexistence in some tissues such as perinatal sensory neuron target tissues ( Hall et al . 2002 ) and pituitary suggests some crosstalk and possible synergy between the two pathways. Indeed, BMP2 is involved in pituitary development ( Ericson et al . 1998
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-4 promotes pituitary prolactinoma pathogenesis through crosstalk between the BMP-4-mediated Smads and the estrogen receptor ( Paez-Pereda et al . 2003 ). BMP-4 also inhibits corticotropic pathogenesis and Cushing's disease in adult pituitary tumor
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pituitary gonadotrope. For instance, BMP-4 promotes pituitary prolactinoma pathogenesis through a Smad–estrogen receptor crosstalk ( Paez-Pereda et al. 2003 ), whereas BMP-4 inhibits corticotropic pathogenesis and Cushing’s disease in adult pituitary tumor