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Chirine Toufaily Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada

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Gauthier Schang Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada

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Xiang Zhou Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada

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Philipp Wartenberg Department of Experimental Pharmacology, Center for Molecular Signaling, Saarland University School of Medicine, Homburg, Germany

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Ulrich Boehm Department of Experimental Pharmacology, Center for Molecular Signaling, Saarland University School of Medicine, Homburg, Germany

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John P Lydon Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Ferdinand Roelfsema Department of Internal Medicine, Section Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

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Daniel J Bernard Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada

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of impairments in LH surges from the pituitary, LH-induced meiotic maturation and ovarian follicle rupture, uterine decidualization, and sexual behavior ( Lydon et al . 1995 , Chappell et al . 1999 ). The LH surge is driven by ovarian estrogens

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Shubhashree Uppangala Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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Akshatha Daddangadi Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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Jeena Susan Joseph Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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Sujit Raj Salian Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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Riddhi Kirit Pandya Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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Guruprasad Kalthur Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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Satish Kumar Adiga Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

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of embryo implantation and decidualization . PNAS 112 15166 – 15171 . ( https://doi.org/10.1073/pnas.1508056112 ) Yuan HJ Han X He N Wang GL Gong S Lin J Gao M Tan JH 2016 Glucocorticoids impair oocyte developmental potential

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Anne R O'Connell Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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Kenneth P McNatty Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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Peter R Hurst Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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Thomas E Spencer Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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Fuller W Bazer Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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Karen L Reader Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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Peter D Johnstone Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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George H Davis Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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Jennifer L Juengel Animal Reproduction, School of Biological Sciences, Department of Anatomy, Department of Animal Sciences, Department of Animal Science, AgResearch Limited, Invermay Agricultural Centre, Puddle Alley Mosgiel, Mosgiel 9092, New Zealand

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. Reproduction 128 657 – 668 . ( doi:10.1530/rep.1.00398 ) Stoikos CJ Harrison CA Salamonsen LA Dimitriadis E 2008 A distinct cohort of the TGFβ superfamily members expressed in human endometrium regulate decidualization . Human Reproduction 23

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F A Hills
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M G Elder
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T Chard
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M H F Sullivan
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and inhibits cytotrophoblast invasion into decidualized endometrial cultures. Growth Hormorne and IGF Research 8 21 –31. Isaka K , Usuda S, Ito H, Sagawa Y, Nakamura H, Nishi H, Suzuki Y, Li YF & Takayama M 2002

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Hwa-Yong Lee Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Tomas J Acosta Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Michiyo Tanikawa Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Ryosuke Sakumoto Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Junichi Komiyama Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Yukari Tasaki Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Mariusz Piskula Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Dariusz J Skarzynski Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Masafumi Tetsuka Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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Kiyoshi Okuda Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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factor I and glucocorticoid receptor in rat uterus and embryo during decidualization, implantation and organogenesis. Reproduction 125 75 –84. Labarca C & Paigen K 1980 A simple, rapid, and sensitive DNA assay procedure

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J Varayoud Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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J G Ramos Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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L Monje Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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V Bosquiazzo Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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M Muñoz-de-Toro Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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E H Luque Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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uterine preparation for implantation and decidualization in the mouse. Endocrinology 140 5310 –5321. Tena-Sempere M , Navarro VM, Mayen A, Bellido C & Sánchez-Criado JE 2004 Regulation of estrogen receptor (ER) isoform

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Andrei G Gunin Department of Obstetrics and Gynecology, Medical School Chuvash State University, PO Box 86, 428034, Cheboksary, Russia

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Irina N Kapitova Department of Obstetrics and Gynecology, Medical School Chuvash State University, PO Box 86, 428034, Cheboksary, Russia

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Nina V Suslonova Department of Obstetrics and Gynecology, Medical School Chuvash State University, PO Box 86, 428034, Cheboksary, Russia

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. Sakai N , Maruyama T, Sakurai R, Masuda H, Yamamoto Y, Shimizu A, Kishi I, Asada H, Yamagoe S & Yoshimura Y 2003 Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. Journal of Biological

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Hyungchul Han Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071, USA
Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA

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Kathleen J Austin Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071, USA
Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA

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Lea A Rempel Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071, USA
Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA

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Thomas R Hansen Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071, USA
Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA

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-reactive protein gene expression is increased in decidualized endometrial stromal cells at the initiation of pregnancy. Molecular Human Reproduction 5 966 –972. Bebington C , Bell SC, Doherty FJ, Fazleabas AT & Fleming SD 1999b

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M A J Hervé INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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G Meduri INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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F G Petit INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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T S Domet INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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G Lazennec INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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S Mourah INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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M Perrot-Applanat INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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, Gustafsson JA, Dahiya R & Cunha GR 2001 Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse. Biology of Reproduction 64 272 –283. Lazennec G , Bresson D

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Tong Sun College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Wen-Bo Deng College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Hong-Lu Diao College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Hua Ni College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Yu-Yan Bai College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Xing-Hong Ma College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Li-Bin Xu College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Zeng-Ming Yang College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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et al. 2000 ). COX-2(−/−) female mice are infertile because of abnormalities in ovulation, fertilization, implantation and decidualization ( Dinchuk et al. 1995 , Lim et al. 1997 ). The defect in ovulation in COX-2 mutants was attributed to

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