transcription and for the terminal differentiation of islet cells ( Chae et al . 2004 ). In NeuroD gene targeting experiments, the combination of NeuroD and betacellulin selectively induced islet related genes in the liver ( Kojima et al . 2003 ). PDX-1/VP16
Search Results
Masaki Nagaya, Hitoshi Katsuta, Hideaki Kaneto, Susan Bonner-Weir, and Gordon C Weir
Hong Lan, Galya Vassileva, Aaron Corona, Li Liu, Hana Baker, Andrei Golovko, Susan J Abbondanzo, Weiwen Hu, Shijun Yang, Yun Ning, Robert A Del Vecchio, Frederique Poulet, Maureen Laverty, Eric L Gustafson, Joseph A Hedrick, and Timothy J Kowalski
and Methods Construction of targeting vector and generation of Gpr119 −/− mice A gene-targeting vector was constructed using the sequence from GenBank accession number NC_000086 . DNA fragments corresponding to the 5′ and 3′ regions of the Gpr119
Kyuyong Han, Haengseok Song, Irene Moon, Robert Augustin, Kelle Moley, Melissa Rogers, and Hyunjung Lim
spermatogenesis including spermatogonia differentiation and spermiation ( Kastner et al. 1996 , Cupp et al. 1999 ). Among RA receptors, roles for RARα and RXRβ in testis functions have been demonstrated in gene-targeted mouse models. RXRβ mutant mice have
Oliver Treeck, Georg Pfeiler, Diana Mitter, Claus Lattrich, Gerhard Piendl, and Olaf Ortmann
. Vendrell JA , Magnino F, Danis E, Duchesne MJ, Pinloche S, Pons M, Birnbaum D, Nguyen C, Theillet C & Cohen PA 2004 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and
Mohan Singh, Parvesh Chaudhry, and Eric Asselin
usually start in mouse models and other species. The prerequisite in this direction is to describe an expression pattern of a molecule followed by more mechanistic approaches such as gene targeting to correct the abnormality. Previous studies have
J Patel, K A Landers, R H Mortimer, and K Richard
2006 ). It is also interesting to note that both C/EBP and AP-1 are up-regulated under hypoxic conditions and closely interact with HIF-1α, leading to the transcription of specific gene targets ( Cummins & Taylor 2005 , Janardhan 2008 ). In this study
Ann E Drummond and Peter J Fuller
Endocrinology 11 353 – 365 . Vendrell JA Magnino F Danis E Duchesne MJ Pinloche S Pons M Birnbaum D Nguyen C Theillet C Cohen PA 2004 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen
Emma Castrique, Marta Fernandez-Fuente, Paul Le Tissier, Andy Herman, and Andy Levy
: rapid reversion of acidophilic cell types to pregestational proportions after weaning . Endocrinology 129 1215 – 1220 . Schmidt-Suppiran M Rajewsky K 2007 Vagaries of conditional gene targeting . Nature Immunology 8 665 – 668 . Srinivas
T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll, and L F Chan
gene targeting was confirmed by long-range PCR and quantitative PCR. Targeted ES cells were microinjected into blastocysts and used to generate chimeras. Germ-line transmission was confirmed by genotyping PCR analyses ( http
Cuili Wang, Dongteng Liu, Weiting Chen, Wei Ge, Wanshu Hong, Yong Zhu, and Shi X Chen
2011 Heritable gene targeting in zebrafish using customized TALENs . Nature Biotechnology 29 699 – 700 . ( doi:10.1038/nbt.1939 ) Huggard-Nelson DL Nathwani PS Kermouni A Habibi HR 2002 Molecular characterization of LH-β and
