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Masaki Nagaya, Hitoshi Katsuta, Hideaki Kaneto, Susan Bonner-Weir, and Gordon C Weir

transcription and for the terminal differentiation of islet cells ( Chae et al . 2004 ). In NeuroD gene targeting experiments, the combination of NeuroD and betacellulin selectively induced islet related genes in the liver ( Kojima et al . 2003 ). PDX-1/VP16

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Hong Lan, Galya Vassileva, Aaron Corona, Li Liu, Hana Baker, Andrei Golovko, Susan J Abbondanzo, Weiwen Hu, Shijun Yang, Yun Ning, Robert A Del Vecchio, Frederique Poulet, Maureen Laverty, Eric L Gustafson, Joseph A Hedrick, and Timothy J Kowalski

and Methods Construction of targeting vector and generation of Gpr119 −/− mice A gene-targeting vector was constructed using the sequence from GenBank accession number NC_000086 . DNA fragments corresponding to the 5′ and 3′ regions of the Gpr119

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Kyuyong Han, Haengseok Song, Irene Moon, Robert Augustin, Kelle Moley, Melissa Rogers, and Hyunjung Lim

spermatogenesis including spermatogonia differentiation and spermiation ( Kastner et al. 1996 , Cupp et al. 1999 ). Among RA receptors, roles for RARα and RXRβ in testis functions have been demonstrated in gene-targeted mouse models. RXRβ mutant mice have

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Oliver Treeck, Georg Pfeiler, Diana Mitter, Claus Lattrich, Gerhard Piendl, and Olaf Ortmann

. Vendrell JA , Magnino F, Danis E, Duchesne MJ, Pinloche S, Pons M, Birnbaum D, Nguyen C, Theillet C & Cohen PA 2004 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and

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Mohan Singh, Parvesh Chaudhry, and Eric Asselin

usually start in mouse models and other species. The prerequisite in this direction is to describe an expression pattern of a molecule followed by more mechanistic approaches such as gene targeting to correct the abnormality. Previous studies have

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J Patel, K A Landers, R H Mortimer, and K Richard

2006 ). It is also interesting to note that both C/EBP and AP-1 are up-regulated under hypoxic conditions and closely interact with HIF-1α, leading to the transcription of specific gene targets ( Cummins & Taylor 2005 , Janardhan 2008 ). In this study

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Ann E Drummond and Peter J Fuller

Endocrinology 11 353 – 365 . Vendrell JA Magnino F Danis E Duchesne MJ Pinloche S Pons M Birnbaum D Nguyen C Theillet C Cohen PA 2004 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen

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Emma Castrique, Marta Fernandez-Fuente, Paul Le Tissier, Andy Herman, and Andy Levy

: rapid reversion of acidophilic cell types to pregestational proportions after weaning . Endocrinology 129 1215 – 1220 . Schmidt-Suppiran M Rajewsky K 2007 Vagaries of conditional gene targeting . Nature Immunology 8 665 – 668 . Srinivas

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T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll, and L F Chan

gene targeting was confirmed by long-range PCR and quantitative PCR. Targeted ES cells were microinjected into blastocysts and used to generate chimeras. Germ-line transmission was confirmed by genotyping PCR analyses ( http

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Cuili Wang, Dongteng Liu, Weiting Chen, Wei Ge, Wanshu Hong, Yong Zhu, and Shi X Chen

2011 Heritable gene targeting in zebrafish using customized TALENs . Nature Biotechnology 29 699 – 700 . ( doi:10.1038/nbt.1939 ) Huggard-Nelson DL Nathwani PS Kermouni A Habibi HR 2002 Molecular characterization of LH-β and