Search Results
Search for other papers by Akiko Mizokami in
Google Scholar
PubMed
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Search for other papers by Satoru Mukai in
Google Scholar
PubMed
Search for other papers by Jing Gao in
Google Scholar
PubMed
Search for other papers by Tomoyo Kawakubo-Yasukochi in
Google Scholar
PubMed
Search for other papers by Takahito Otani in
Google Scholar
PubMed
Search for other papers by Hiroshi Takeuchi in
Google Scholar
PubMed
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Search for other papers by Eijiro Jimi in
Google Scholar
PubMed
Search for other papers by Masato Hirata in
Google Scholar
PubMed
et al. 2014 ) or indirectly through stimulation of the secretion of glucagon-like peptide-1 (GLP-1) from intestinal endocrine cells ( Mizokami et al. 2013 , 2014 ). GLP-1 is a member of the incretin family of hormones that are secreted from
Search for other papers by Xianxian Huang in
Google Scholar
PubMed
Search for other papers by Jing Liu in
Google Scholar
PubMed
Search for other papers by Guangquan Peng in
Google Scholar
PubMed
Search for other papers by Mingyue Lu in
Google Scholar
PubMed
Search for other papers by Zhongbo Zhou in
Google Scholar
PubMed
Search for other papers by Neng Jiang in
Google Scholar
PubMed
Search for other papers by Zhiming Yan in
Google Scholar
PubMed
, glucagon-like peptide 1; GIP, glucose-dependent insulinotropic peptide; GLP-1R, glucagon-like peptide 1 receptor; GIPR, glucose-dependent insulinotropic peptide receptor; GLP-1RA, glucagon-like peptide 1 receptor agonist; T2DM, type 2 diabetes mellitus
Search for other papers by Jennifer S ten Kulve in
Google Scholar
PubMed
Search for other papers by Dick J Veltman in
Google Scholar
PubMed
Search for other papers by Liselotte van Bloemendaal in
Google Scholar
PubMed
Search for other papers by Paul F C Groot in
Google Scholar
PubMed
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands
Search for other papers by Henricus G Ruhé in
Google Scholar
PubMed
Search for other papers by Frederik Barkhof in
Google Scholar
PubMed
Search for other papers by Michaela Diamant in
Google Scholar
PubMed
Search for other papers by Richard G Ijzerman in
Google Scholar
PubMed
, Cummings 2013 ), except for glucagon-like peptide-1 (GLP1). GLP1 is a gut-derived hormone, mainly known for its glucose-lowering effects ( Kreymann et al. 1987 , Mojsov et al. 1987 ); however, numerous preclinical and clinical studies have shown that
Search for other papers by Wenjuan Liu in
Google Scholar
PubMed
Search for other papers by Harry Kevin Lau in
Google Scholar
PubMed
Search for other papers by Dong Ok Son in
Google Scholar
PubMed
Division of Advanced Diagnostics, Toronto General Research Institutes, University Health Network, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
Search for other papers by Tianru Jin in
Google Scholar
PubMed
Search for other papers by Yehong Yang in
Google Scholar
PubMed
Search for other papers by Zhaoyun Zhang in
Google Scholar
PubMed
Search for other papers by Yiming Li in
Google Scholar
PubMed
Search for other papers by Gerald J Prud’homme in
Google Scholar
PubMed
Search for other papers by Qinghua Wang in
Google Scholar
PubMed
the β-cell mass and provide improved treatments for T1D and T2D subjects. Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gastrointestinal L cells in response to food ingestion, and has been currently used for the treatment of T2
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by M-J Kim in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by J-H Kang in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by Y G Park in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by G R Ryu in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by S H Ko in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by I-K Jeong in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by K-H Koh in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by D-J Rhie in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by S H Yoon in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by S J Hahn in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by M-S Kim in
Google Scholar
PubMed
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea
Search for other papers by Y-H Jo in
Google Scholar
PubMed
Introduction Glucagon-like peptide-1 (GLP-1) has been of much interest due to its β-cell-proliferating effect and role as an incretin hormone in synergizing with glucose to enhance insulin release ( Ørskov 1992 , Egan et al. 2003
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Search for other papers by Mohamed Lotfy in
Google Scholar
PubMed
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Search for other papers by Jaipaul Singh in
Google Scholar
PubMed
Search for other papers by Hameed Rashed in
Google Scholar
PubMed
Search for other papers by Saeed Tariq in
Google Scholar
PubMed
Search for other papers by Erika Zilahi in
Google Scholar
PubMed
Search for other papers by Ernest Adeghate in
Google Scholar
PubMed
endocrine and an exocrine system with much interaction between the two parts ( Shetzline & Liddle 2002 ). The GI tract secretes a number of hormones including glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP1; Drucker 2003 b
Search for other papers by Christian Hölscher in
Google Scholar
PubMed
Introduction The main hallmark of type 2 diabetes mellitus (T2DM) is insulin desensitisation. The discovery that the incretin hormone glucagon-like peptide 1 (GLP-1) facilitates insulin release during episodes of hyperglycaemia and has several
Search for other papers by Jonathan D Douros in
Google Scholar
PubMed
Search for other papers by Jacek Mokrosinski in
Google Scholar
PubMed
Search for other papers by Brian Finan in
Google Scholar
PubMed
disadvantageous regulatory mechanisms in a cell-targeted, pathophysiology-specific manner. This review aims to outline the current understanding of signaling bias at the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) in three broad categories: (i) ligand
Search for other papers by Zhengu Liu in
Google Scholar
PubMed
Search for other papers by Violeta Stanojevic in
Google Scholar
PubMed
Search for other papers by Luke J Brindamour in
Google Scholar
PubMed
Search for other papers by Joel F Habener in
Google Scholar
PubMed
of glucagon-like peptide-1 (GLP1; Tomas & Habener 2010 ) enters glucolipotoxic-stressed INS-1 β-cells and inhibits stress-induced apoptosis. We showed earlier that the C-terminal nonapeptide, GLP1(28–36)amide, derived from GLP1 enters insulin
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Search for other papers by Yoon Sin Oh in
Google Scholar
PubMed
Search for other papers by Youn-Jung Lee in
Google Scholar
PubMed
Search for other papers by Yup Kang in
Google Scholar
PubMed
Search for other papers by Jaeseok Han in
Google Scholar
PubMed
Search for other papers by Oh-Kyung Lim in
Google Scholar
PubMed
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Search for other papers by Hee-Sook Jun in
Google Scholar
PubMed
-cells and diabetes mellitus . Experimental Biology and Medicine 228 1213 – 1217 . Cunha DA Ladriere L Ortis F Igoillo-Esteve M Gurzov EN Lupi R Marchetti P Eizirik DL Cnop M 2009 Glucagon-like peptide-1 agonists protect pancreatic