Search Results

You are looking at 71 - 80 of 328 items for :

  • "glucagon-like peptide-1" x
  • Refine by access: All content x
Clear All
Akiko Mizokami OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Search for other papers by Akiko Mizokami in
Google Scholar
PubMed
Close
,
Satoru Mukai OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Search for other papers by Satoru Mukai in
Google Scholar
PubMed
Close
,
Jing Gao Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Search for other papers by Jing Gao in
Google Scholar
PubMed
Close
,
Tomoyo Kawakubo-Yasukochi Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

Search for other papers by Tomoyo Kawakubo-Yasukochi in
Google Scholar
PubMed
Close
,
Takahito Otani Division of Functional Structure, Department of Morphological Biology, School of Dental Medicine, Fukuoka Dental College, Fukuoka, Japan

Search for other papers by Takahito Otani in
Google Scholar
PubMed
Close
,
Hiroshi Takeuchi Division of Applied Pharmacology, Kyushu Dental University, Kitakyushu, Japan

Search for other papers by Hiroshi Takeuchi in
Google Scholar
PubMed
Close
,
Eijiro Jimi OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Search for other papers by Eijiro Jimi in
Google Scholar
PubMed
Close
, and
Masato Hirata Oral Medicine Research Center, School of Dental Medicine, Fukuoka Dental College, Fukuoka, Japan

Search for other papers by Masato Hirata in
Google Scholar
PubMed
Close

et al. 2014 ) or indirectly through stimulation of the secretion of glucagon-like peptide-1 (GLP-1) from intestinal endocrine cells ( Mizokami et al. 2013 , 2014 ). GLP-1 is a member of the incretin family of hormones that are secreted from

Restricted access
Xianxian Huang Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China

Search for other papers by Xianxian Huang in
Google Scholar
PubMed
Close
,
Jing Liu Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China

Search for other papers by Jing Liu in
Google Scholar
PubMed
Close
,
Guangquan Peng Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China

Search for other papers by Guangquan Peng in
Google Scholar
PubMed
Close
,
Mingyue Lu Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China

Search for other papers by Mingyue Lu in
Google Scholar
PubMed
Close
,
Zhongbo Zhou School of Pharmacy, Youjiang Medical University for Nationalities, Baise, Guangxi, China

Search for other papers by Zhongbo Zhou in
Google Scholar
PubMed
Close
,
Neng Jiang Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China

Search for other papers by Neng Jiang in
Google Scholar
PubMed
Close
, and
Zhiming Yan Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China

Search for other papers by Zhiming Yan in
Google Scholar
PubMed
Close

, glucagon-like peptide 1; GIP, glucose-dependent insulinotropic peptide; GLP-1R, glucagon-like peptide 1 receptor; GIPR, glucose-dependent insulinotropic peptide receptor; GLP-1RA, glucagon-like peptide 1 receptor agonist; T2DM, type 2 diabetes mellitus

Restricted access
Jennifer S ten Kulve Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Jennifer S ten Kulve in
Google Scholar
PubMed
Close
,
Dick J Veltman Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Dick J Veltman in
Google Scholar
PubMed
Close
,
Liselotte van Bloemendaal Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Liselotte van Bloemendaal in
Google Scholar
PubMed
Close
,
Paul F C Groot Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands

Search for other papers by Paul F C Groot in
Google Scholar
PubMed
Close
,
Henricus G Ruhé Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands

Search for other papers by Henricus G Ruhé in
Google Scholar
PubMed
Close
,
Frederik Barkhof Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Frederik Barkhof in
Google Scholar
PubMed
Close
,
Michaela Diamant Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Michaela Diamant in
Google Scholar
PubMed
Close
, and
Richard G Ijzerman Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Richard G Ijzerman in
Google Scholar
PubMed
Close

, Cummings 2013 ), except for glucagon-like peptide-1 (GLP1). GLP1 is a gut-derived hormone, mainly known for its glucose-lowering effects ( Kreymann et al. 1987 , Mojsov et al. 1987 ); however, numerous preclinical and clinical studies have shown that

Free access
Wenjuan Liu Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

Search for other papers by Wenjuan Liu in
Google Scholar
PubMed
Close
,
Harry Kevin Lau Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada

Search for other papers by Harry Kevin Lau in
Google Scholar
PubMed
Close
,
Dong Ok Son Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada

Search for other papers by Dong Ok Son in
Google Scholar
PubMed
Close
,
Tianru Jin Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Advanced Diagnostics, Toronto General Research Institutes, University Health Network, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

Search for other papers by Tianru Jin in
Google Scholar
PubMed
Close
,
Yehong Yang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

Search for other papers by Yehong Yang in
Google Scholar
PubMed
Close
,
Zhaoyun Zhang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

Search for other papers by Zhaoyun Zhang in
Google Scholar
PubMed
Close
,
Yiming Li Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

Search for other papers by Yiming Li in
Google Scholar
PubMed
Close
,
Gerald J Prud’homme Department of Laboratory Medicine and Pathobiology, Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

Search for other papers by Gerald J Prud’homme in
Google Scholar
PubMed
Close
, and
Qinghua Wang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

Search for other papers by Qinghua Wang in
Google Scholar
PubMed
Close

the β-cell mass and provide improved treatments for T1D and T2D subjects. Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gastrointestinal L cells in response to food ingestion, and has been currently used for the treatment of T2

Restricted access
M-J Kim Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by M-J Kim in
Google Scholar
PubMed
Close
,
J-H Kang Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by J-H Kang in
Google Scholar
PubMed
Close
,
Y G Park Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by Y G Park in
Google Scholar
PubMed
Close
,
G R Ryu Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by G R Ryu in
Google Scholar
PubMed
Close
,
S H Ko Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by S H Ko in
Google Scholar
PubMed
Close
,
I-K Jeong Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by I-K Jeong in
Google Scholar
PubMed
Close
,
K-H Koh Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by K-H Koh in
Google Scholar
PubMed
Close
,
D-J Rhie Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by D-J Rhie in
Google Scholar
PubMed
Close
,
S H Yoon Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by S H Yoon in
Google Scholar
PubMed
Close
,
S J Hahn Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by S J Hahn in
Google Scholar
PubMed
Close
,
M-S Kim Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by M-S Kim in
Google Scholar
PubMed
Close
, and
Y-H Jo Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

Search for other papers by Y-H Jo in
Google Scholar
PubMed
Close

Introduction Glucagon-like peptide-1 (GLP-1) has been of much interest due to its β-cell-proliferating effect and role as an incretin hormone in synergizing with glucose to enhance insulin release ( Ørskov 1992 , Egan et al. 2003

Free access
Mohamed Lotfy Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

Search for other papers by Mohamed Lotfy in
Google Scholar
PubMed
Close
,
Jaipaul Singh Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

Search for other papers by Jaipaul Singh in
Google Scholar
PubMed
Close
,
Hameed Rashed Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

Search for other papers by Hameed Rashed in
Google Scholar
PubMed
Close
,
Saeed Tariq Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

Search for other papers by Saeed Tariq in
Google Scholar
PubMed
Close
,
Erika Zilahi Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

Search for other papers by Erika Zilahi in
Google Scholar
PubMed
Close
, and
Ernest Adeghate Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

Search for other papers by Ernest Adeghate in
Google Scholar
PubMed
Close

endocrine and an exocrine system with much interaction between the two parts ( Shetzline & Liddle 2002 ). The GI tract secretes a number of hormones including glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP1; Drucker 2003 b

Free access
Christian Hölscher Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK

Search for other papers by Christian Hölscher in
Google Scholar
PubMed
Close

Introduction The main hallmark of type 2 diabetes mellitus (T2DM) is insulin desensitisation. The discovery that the incretin hormone glucagon-like peptide 1 (GLP-1) facilitates insulin release during episodes of hyperglycaemia and has several

Free access
Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

Search for other papers by Jonathan D Douros in
Google Scholar
PubMed
Close
,
Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

Search for other papers by Jacek Mokrosinski in
Google Scholar
PubMed
Close
, and
Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

Search for other papers by Brian Finan in
Google Scholar
PubMed
Close

disadvantageous regulatory mechanisms in a cell-targeted, pathophysiology-specific manner. This review aims to outline the current understanding of signaling bias at the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) in three broad categories: (i) ligand

Restricted access
Zhengu Liu Laboratory of Molecular Endocrinology, Their 306, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Search for other papers by Zhengu Liu in
Google Scholar
PubMed
Close
,
Violeta Stanojevic Laboratory of Molecular Endocrinology, Their 306, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Search for other papers by Violeta Stanojevic in
Google Scholar
PubMed
Close
,
Luke J Brindamour Laboratory of Molecular Endocrinology, Their 306, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Search for other papers by Luke J Brindamour in
Google Scholar
PubMed
Close
, and
Joel F Habener Laboratory of Molecular Endocrinology, Their 306, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Search for other papers by Joel F Habener in
Google Scholar
PubMed
Close

of glucagon-like peptide-1 (GLP1; Tomas & Habener 2010 ) enters glucolipotoxic-stressed INS-1 β-cells and inhibits stress-induced apoptosis. We showed earlier that the C-terminal nonapeptide, GLP1(28–36)amide, derived from GLP1 enters insulin

Free access
Yoon Sin Oh Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Yoon Sin Oh in
Google Scholar
PubMed
Close
,
Youn-Jung Lee Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Youn-Jung Lee in
Google Scholar
PubMed
Close
,
Yup Kang Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Yup Kang in
Google Scholar
PubMed
Close
,
Jaeseok Han Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Jaeseok Han in
Google Scholar
PubMed
Close
,
Oh-Kyung Lim Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Oh-Kyung Lim in
Google Scholar
PubMed
Close
, and
Hee-Sook Jun Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Hee-Sook Jun in
Google Scholar
PubMed
Close

-cells and diabetes mellitus . Experimental Biology and Medicine 228 1213 – 1217 . Cunha DA Ladriere L Ortis F Igoillo-Esteve M Gurzov EN Lupi R Marchetti P Eizirik DL Cnop M 2009 Glucagon-like peptide-1 agonists protect pancreatic

Free access