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H Takahashi, Y Kurose, S Kobayashi, T Sugino, M Kojima, K Kangawa, Y Hasegawa, and Y Terashima

been reported in ruminants. In scheduled meal-fed sheep, therefore, we examined the effects of ghrelin administration on insulin secretory response to glucose load and on insulin sensitivity in the postprandial period, when insulin secretory response is

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May Faraj, Genevieve Beauregard, Emmanuelle Loizon, Marthe Moldes, Karine Clément, Youssef Tahiri, Katherine Cianflone, Hubert Vidal, and Rémi Rabasa-Lhoret

data. S.c. WAT adiponutrin expression was not increased in obese subjects and was associated with insulin sensitivity in one study ( Liu et al. 2004 ) but not in the other (where insulin sensitivity was associated with adiponutrin expression in

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Sergio Di Meo, Susanna Iossa, and Paola Venditti

treatment have been intensified. In addition to dietary regimes aimed at weight loss, two major non-pharmacological approaches to improve insulin sensitivity have included antioxidant supplementation and exercise training. In recent years, antioxidants

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Sung-Soo Park, Yeon-Joo Lee, Sooyeon Song, Boyong Kim, Hyuno Kang, Sejong Oh, and Eungseok Kim

activation, respectively, resulting in protection against HFD-induced obesity and fat accumulation in the liver, with improvement in insulin sensitivity. Furthermore, AMPK was shown to play a key role in LNS1-mediated regulation of PPARα and SREBP-1c

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Muraly Puttabyatappa, Robert M Sargis, and Vasantha Padmanabhan

offspring exhibit postnatal signs of reduced insulin sensitivity ( Tamhane et al . 2018 ). Evidence indicates that during pregnancy women with PCOS have higher androgen levels with associated disruptions in placental steroidogenesis ( Sir-Petermann et al

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Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, and Nobuya Inagaki

composition, glucose tolerance, and insulin sensitivity under carbohydrate-based normal diet feeding condition using GIP-knockout mice. Materials and methods Animals GIP-knockout mice were generated previously ( Nasteska et al . 2014 ). GIP

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Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens Jr, and Brant R Burkhardt

by GTT performed on 6-month-old mice, but both groups showed elevated glucose levels during the course of GTT as compared with the younger cohort ( Fig. 3 B). To evaluate peripheral insulin sensitivity, ITTs were performed. ITT results demonstrated

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Ljupka Gligorovska, Biljana Bursać, Sanja Kovačević, Nataša Veličković, Gordana Matić, and Ana Djordjevic

reporting that Mif - knockout mice display improved insulin sensitivity and glucose tolerance ( Verschuren et al. 2009 , Kleemann & Bucala 2010 ). Although MIF synthesis and secretion are upregulated by the glucocorticoid hormones (GCs), MIF acts as

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M Skrzypski, M Billert, K W Nowak, and M Z Strowski

). Furthermore, orexin is required to maintain motor activity ( Hara et al . 2001 ) as well hypothalamic insulin signaling, which results in improvement of peripheral insulin sensitivity ( Tsuneki et al . 2008 ). Maintenance of body weight and energy

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Marco Hatem-Vaquero, Mercedes Griera, Andrea García-Jerez, Alicia Luengo, Julia Álvarez, José A Rubio, Laura Calleros, Diego Rodríguez-Puyol, Manuel Rodríguez-Puyol, and Sergio De Frutos

homeostasis model assessment of insulin resistance (HOMA-IR, fasting glycemia in mg/dL multiplied by fasting insulinemia in µU/mL, divided to 405) and the quantitative insulin sensitivity check index (QUICKI, 1 divided to log fasting insulinemia in µU/mL plus