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Isabelle Leclerc, Guy A Rutter, Gargi Meur, and Nafeesa Noordeen

-term storage ( Uyeda & Repa 2006 ). Mice deleted for both alleles of Mlxipl display diminished rates of hepatic glycolysis and lipogenesis resulting in high liver glycogen content, low plasma free fatty acid and reduced adipose tissue mass ( Iizuka et al

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Daniel M Kelly and T Hugh Jones

lipogenesis further increases lipid content and can lead to hepatic steatosis. Impaired insulin action in the adipose tissue allows for increased lipolysis, which additionally promotes re-esterification of lipids in other tissues (such as liver and muscle) and

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Yingning Ji, Wei Liu, Yemin Zhu, Yakui Li, Ying Lu, Qi Liu, Lingfeng Tong, Lei Hu, Nannan Xu, Zhangbing Chen, Na Tian, Lifang Wu, Lian Zhu, Shuang Tang, Ping Zhang, and Xuemei Tong

de novo lipogenesis ( Townsend & Tseng 2014 , Marlatt & Ravussin 2017 ). Although our previous findings have revealed the role of TKT in limiting lipolysis and fatty acid oxidation in adipose tissues ( Tian et al. 2020 ), the function of TKT in

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Alia H Sukkar, Aaron M Lett, Gary Frost, and Edward S Chambers

substrate for de novo lipogenesis. Propionate enters the TCA cycle as succinyl-CoA, which can be used as a precursor for hepatic gluconeogenesis. The maximum ATP (adenosine triphosphate) yield from complete oxidation of acetate, propionate and butyrate is

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Liping Luo and Meilian Liu

storage organ, adipose tissue stores TGs and releases fatty acids through lipogenesis and lipolysis, respectively. Systemically, feeding stimulates the lipogenic pathway and storage of TGs in the adipose tissue, while fasting induces the activation of

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Shaodong Guo

K) and eukaryotic initiation factor 4E-binding protein (4E-BP), both of which control protein synthesis. Recent data indicate that mTORC1 promotes lipogenesis via the phosphorylation of a phosphatidic acid phosphatase Lipin 1 and nuclear

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Aldo Grefhorst, Johanna C van den Beukel, Wieneke Dijk, Jacobie Steenbergen, Gardi J Voortman, Selmar Leeuwenburgh, Theo J Visser, Sander Kersten, Edith C H Friesema, Axel P N Themmen, and Jenny A Visser

lipogenesis has been shown before in liver slices from rats exposed to cold that had a reduced ability to convert 14 C-acetate into 14 C-fatty acids ( Masoro et al. 1957 ). Our data show that the reduced hepatic lipogenesis is the result of the reduced

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Shu-Fang Xia, Xiao-Mei Duan, Xiang-Rong Cheng, Li-Mei Chen, Yan-Jun Kang, Peng Wang, Xue Tang, Yong-Hui Shi, and Guo-Wei Le

. Here, we further investigated part of TH responsive genes that involved in lipogenesis ( Srebp1c , Acc1 , Scd1 and Fasn ), lipid mobilization and fatty acid oxidation genes ( Cpt1α , Lpl and Fabp ), energy metabolism ( Atp5c1 and Cox7c ) and

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Bel M Galmés-Pascual, Antonia Nadal-Casellas, Marco Bauza-Thorbrügge, Miquel Sbert-Roig, Francisco J García-Palmer, Ana M Proenza, Magdalena Gianotti, and Isabel Lladó

above in combination with increased lipogenesis, such as the higher Srebp1c mRNA levels shown, caused hepatic triglyceride accumulation. In contrast, E2 replacement ameliorated mitochondrial function and biogenesis of OVX rats, accompanied by

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Bethany P Cummings, Ahmed Bettaieb, James L Graham, Kimber Stanhope, Fawaz G Haj, and Peter J Havel

triglyceride (TG) concentrations ( P <0.001; Fig. 4 A, B and C). Enzymes involved in the regulation of fatty acid oxidation and lipogenesis were measured in subcutaneous WAT and BAT by immunoblotting in order to perform an initial investigation of the