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th column. In case of ↑ or ↓ the lowest dose at which the effect has been reported is listed in the 4th column. * Only the studies that corrected for cross-reactivity of TA 3 in the T 3 assay are listed. BMR, basal metabolic rate; CHD
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in triiodothyronine and thyroxine concentrations by 40–47% after a 7 -day challenge. This has been expected as essential in order to ensure the demand for a reduced metabolic rate and to confine increase in body temperature in these animals ( McGuire
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Fgf19 showed reduced blood glucose, lipid and insulin levels, improved insulin sensitivity, dramatically reduced body weight and improved energy metabolism with increased metabolic rate and energy expenditure ( Tomlinson et al . 2002 ). These
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metabolic rate are also likely to be much reduced ( Breton et al. 1983 ). In good accord with this, in the current study, the peptidic GCGR antagonists both decreased physical activity in HFF-STZ mice. However, the ability of desHis 1 Pro 4 Glu 9 -glucagon
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vital findings regarding appetite and human eating behaviour. Through complex, multi-level study designs, we have been able to show a relationship among fat-free mass, resting metabolic rate and meal size. Additionally, the relationship between appetite
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for 10 days, but resting metabolic rate was not elevated when the patients returned to thermoneutrality ( van der Lans et al . 2013 ). It can certainly be argued that if a conversion of additional human WAT depots to beige fat were possible, resulting
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Department of Anatomy, Semmelweis University, Budapest, Hungary
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Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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controls body weight and metabolic rate ( Mizuno et al . 2003 )). In contrast, Crh mRNA expression fails to meet these criteria: t -SNE projections demonstrate widespread Crh expression in hypothalamic neurons, which lack subtype definition. In accord
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Dipartimento di Biologia, Dipartimento di Scienze Biologiche ed Ambientali, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Corso Europa 26, Genova 16132, Italy
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Dipartimento di Biologia, Dipartimento di Scienze Biologiche ed Ambientali, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Corso Europa 26, Genova 16132, Italy
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several effects of 3,3′,5- l -triiodothyronine (T 3 ) on energy metabolism without inducing thyrotoxic effects ( Cimmino et al . 1996 , Lanni et al . 2005 ). Also T 2 , as T 3 , is able to stimulate both resting metabolic rate and mitochondrial activity
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( Almind & Kahn 2004 , Champy et al. 2008 , Tschöp et al. 2011 ). This resistance to obesity in FVB compared to B6 mice is related to higher metabolic rate, while caloric intake on a HFD is similar between backgrounds ( Almind & Kahn 2004 ). Therefore
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increased basal metabolic rate ( Alemzadeh et al. 2008 ) in obese Zucker Fatty Rats and Otsuka Long–Evans Tokushima Fatty Rats. In the DIO mice, which reflected general human obesity, we observed similar results ( Fig. 4I , K and O ). Both reduced food