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Malek El Muayed
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Liana K Billings Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Massachusetts General Hospital, Harvard University, The Chemistry of Life Processes Institute and Department of Chemistry, Northwestern University, Division of Transplant Surgery, Feinberg School of Medicine, Northwestern University, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA

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Meera R Raja Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Massachusetts General Hospital, Harvard University, The Chemistry of Life Processes Institute and Department of Chemistry, Northwestern University, Division of Transplant Surgery, Feinberg School of Medicine, Northwestern University, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA

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Xiaomin Zhang Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Massachusetts General Hospital, Harvard University, The Chemistry of Life Processes Institute and Department of Chemistry, Northwestern University, Division of Transplant Surgery, Feinberg School of Medicine, Northwestern University, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA

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Paul J Park Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Massachusetts General Hospital, Harvard University, The Chemistry of Life Processes Institute and Department of Chemistry, Northwestern University, Division of Transplant Surgery, Feinberg School of Medicine, Northwestern University, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA

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Marsha V Newman
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Dixon B Kaufman Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Massachusetts General Hospital, Harvard University, The Chemistry of Life Processes Institute and Department of Chemistry, Northwestern University, Division of Transplant Surgery, Feinberg School of Medicine, Northwestern University, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA

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Thomas V O'Halloran Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Massachusetts General Hospital, Harvard University, The Chemistry of Life Processes Institute and Department of Chemistry, Northwestern University, Division of Transplant Surgery, Feinberg School of Medicine, Northwestern University, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA

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William L Lowe Jr
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decreased Zn accumulation in islets ( Lemaire et al . 2009 , Nicolson et al . 2009 , Pound et al . 2009 ). ZnT8 null mice also exhibited decreased GSIS and altered glucose homeostasis ( Pound et al . 2009 ). However, ZnT8 null mice exhibited altered

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0420
Volume/Issue:
Volume 206: Issue 2
Free access
Sofianos Andrikopoulos Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Barbara C Fam Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Anita Holdsworth Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Sherley Visinoni Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Zheng Ruan Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Maria Stathopoulos Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Anne W Thorburn Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Christos N Joannides Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Michael Cancilla Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Lois Balmer Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia
Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Joseph Proietto Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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Grant Morahan Department of Medicine (AH), Walter and Eliza Hall Institute of Medical Research, Harry Perkins Institute of Medical Research, The School of Medical Sciences Edith Cowan University, Austin Hospital, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia

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secretion ( Seghers et al . 2000 , Nakazaki et al . 2002 , Shiota et al . 2002 ). Furthermore, the response of the SUR1 null mice to non-glucose stimuli such as carbachol, TPA, amino acids, acetylcholine and IBMX was comparable with the control mice

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0290
Volume/Issue:
Volume 228: Issue 1
Free access
Saira Hameed Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Channa N Jayasena Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Waljit S Dhillo Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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hypogonadism of kiss1r −/− and kiss1 −/− null mice ( de Roux et al . 2003 , Seminara et al . 2003 , d'Anglemont de Tassigny et al . 2007 ). These mice have normal levels of hypothalamic GnRH. As expected, kisspeptin administration to Kiss1 −/− mice

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0265
Volume/Issue:
Volume 208: Issue 2
Free access
Aarti D Rohira Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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David M Lonard Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Bert W O’Malley Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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coactivators in regulating energy metabolism ( Dasgupta et al. 2014 ). Whole body knockout of SRC-1 in mice causes an increased risk of obesity due to decreased energy expenditure. SRC-1 null mice also display hypoglycemia due to impaired hepatic

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0511
Volume/Issue:
Volume 248: Issue 2
Free access
Thomas M Braxton School of Biosciences, Cardiff University, Cardiff, UK

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Dionne E A Sarpong School of Biosciences, Cardiff University, Cardiff, UK

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Janine L Dovey School of Biosciences, Cardiff University, Cardiff, UK

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Anne Guillou IGF, CNRS, INSERM, University of Montpellier, Montpellier, France

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Bronwen A J Evans School of Medicine, Cardiff University, Cardiff, UK

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Juan M Castellano Physiology Section, Faculty of Medicine, University of Cordoba, and Instituto Maimonides de Investigacion Biomedica de Cordoba (IMBIC), Cordoba, Spain

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Bethany E Keenan School of Engineering, Cardiff University, Cardiff, UK

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Saja Baraghithy Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

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Sam L Evans School of Engineering, Cardiff University, Cardiff, UK

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Manuel Tena-Sempere Physiology Section, Faculty of Medicine, University of Cordoba, and Instituto Maimonides de Investigacion Biomedica de Cordoba (IMBIC), Cordoba, Spain
CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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Patrice Mollard IGF, CNRS, INSERM, University of Montpellier, Montpellier, France

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Joseph Tam Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

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Timothy Wells School of Biosciences, Cardiff University, Cardiff, UK

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phenotypic characteristics. For example, while loss of the MAGE -family gene, Necdin has no effect on growth or adiposity ( Cattanach et al. 1992 , Muscatelli et al. 2000 ) Necdin -null mice display enhanced differentiation and/or proliferation of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0279
Volume/Issue:
Volume 243: Issue 3
Restricted access
Gerard Karsenty Department of Genetics and Development, Columbia University, HHSC 701 West 168th Street, HHSC1602, New York, New York 10032, USA

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Physiology of bone loss . Radiologic Clinics of North America 48 483 – 495 . doi:10.1016/j.rcl.2010.02.014 . Couse JF Korach KS 1999 Estrogen receptor null mice: what have we learned and where will they lead us? Endocrine Reviews 20 358

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0452
Volume/Issue:
Volume 213: Issue 2
Free access
Jorge N Artaza Division of Endocrinology Metabolism and Molecular Medicine,
Department of Biomedical Sciences and
RCMI DNA Molecular Core, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, California 90017, USA
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, Massachusetts 02118, USA

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Suzanne Reisz-Porszasz Division of Endocrinology Metabolism and Molecular Medicine,
Department of Biomedical Sciences and
RCMI DNA Molecular Core, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, California 90017, USA
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, Massachusetts 02118, USA

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Joan S Dow Division of Endocrinology Metabolism and Molecular Medicine,
Department of Biomedical Sciences and
RCMI DNA Molecular Core, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, California 90017, USA
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, Massachusetts 02118, USA

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Robert A Kloner Division of Endocrinology Metabolism and Molecular Medicine,
Department of Biomedical Sciences and
RCMI DNA Molecular Core, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, California 90017, USA
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, Massachusetts 02118, USA

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James Tsao Division of Endocrinology Metabolism and Molecular Medicine,
Department of Biomedical Sciences and
RCMI DNA Molecular Core, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, California 90017, USA
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, Massachusetts 02118, USA

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Shalender Bhasin Division of Endocrinology Metabolism and Molecular Medicine,
Department of Biomedical Sciences and
RCMI DNA Molecular Core, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, California 90017, USA
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, Massachusetts 02118, USA

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Nestor F Gonzalez-Cadavid Division of Endocrinology Metabolism and Molecular Medicine,
Department of Biomedical Sciences and
RCMI DNA Molecular Core, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, California 90017, USA
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, Massachusetts 02118, USA

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(−/−), mice, provided kindly by Dr S J Lee, were bred in our vivarium (BalbC/Mst (−/−); McPherron et al. 1997). As reported previously by Dr Lee’s group, these Mst null mice show greater muscularity and lower fat mass than age-matched wild-type (WT) controls

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0072
Volume/Issue:
Volume 194: Issue 1
Free access
Evelyn Davies Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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Selma Omer Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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John F Morris Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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Helen C Christian Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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has so far been studied almost exclusively in male rodents and it is not known how ANXA1 varies with the estrous cycle of the rat and the female sex estrogen status. Our recent findings demonstrate that ANXA1 null mice exhibit sexual dimorphisms in HPA

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0132
Volume/Issue:
Volume 192: Issue 2
Free access
Ying Wang Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Xiao-Hui Wang Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Deng-Xuan Fan Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Yuan Zhang Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Ming-Qing Li Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Hai-Xia Wu Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Li-Ping Jin Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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( Artenstein & Opal 2011 ). In the reproductive system, PCs participate in follicle and embryo development. Male Pcsk4 -null mice exhibited severely impaired fertility and female Pcsk4 -null mice exhibited delayed folliculogenesis in the ovaries ( Mbikay et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0592
Volume/Issue:
Volume 222: Issue 1
Free access
Hong Liu Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College

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Jian Guo Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College

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Lin Wang Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College

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Ning Chen Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College

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Andrew Karaplis Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College

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David Goltzman Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College

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Dengshun Miao Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College

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mandibles. Materials and Methods 1α(OH)ase and PTH null mice and genotyping The generation of 1α(OH)ase −/− and PTH −/− mice and mouse genotyping were described previously ( Panda et al . 2001 , Xue et al . 2005 ). The mice were fed autoclaved rodent

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0247
Volume/Issue:
Volume 203: Issue 2
Free access