Search Results
G M Ledda-Columbano
G M Ledda-Columbano
Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Search for other papers by G M Ledda-Columbano in
Google Scholar
PubMed
Search for other papers by G M Ledda-Columbano in
Google Scholar
PubMed
A Perra
A Perra
Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Search for other papers by A Perra in
Google Scholar
PubMed
Search for other papers by A Perra in
Google Scholar
PubMed
M Pibiri
M Pibiri
Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Search for other papers by M Pibiri in
Google Scholar
PubMed
Search for other papers by M Pibiri in
Google Scholar
PubMed
F Molotzu
F Molotzu
Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Search for other papers by F Molotzu in
Google Scholar
PubMed
Search for other papers by F Molotzu in
Google Scholar
PubMed
A Columbano
A Columbano
Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Search for other papers by A Columbano in
Google Scholar
PubMed
Search for other papers by A Columbano in
Google Scholar
PubMed
peroxisome proliferator-activated receptors (PPARs) and some orphan receptors ( Mangelsdorf et al. 1984 ). In the past few years it has become evident that several ligands of the steroid/thyroid hormone receptor superfamily possess mitogenic activity for
Koji Nagayama
Koji Nagayama
Search for other papers by Koji Nagayama in
Google Scholar
PubMed
Search for other papers by Koji Nagayama in
Google Scholar
PubMed
Shigekazu Sasaki
Shigekazu Sasaki
Search for other papers by Shigekazu Sasaki in
Google Scholar
PubMed
Search for other papers by Shigekazu Sasaki in
Google Scholar
PubMed
Akio Matsushita
Akio Matsushita
Search for other papers by Akio Matsushita in
Google Scholar
PubMed
Search for other papers by Akio Matsushita in
Google Scholar
PubMed
Kenji Ohba
Kenji Ohba
Search for other papers by Kenji Ohba in
Google Scholar
PubMed
Search for other papers by Kenji Ohba in
Google Scholar
PubMed
Hiroyuki Iwaki
Hiroyuki Iwaki
Search for other papers by Hiroyuki Iwaki in
Google Scholar
PubMed
Search for other papers by Hiroyuki Iwaki in
Google Scholar
PubMed
Hideyuki Matsunaga
Hideyuki Matsunaga
Search for other papers by Hideyuki Matsunaga in
Google Scholar
PubMed
Search for other papers by Hideyuki Matsunaga in
Google Scholar
PubMed
Shingo Suzuki
Shingo Suzuki
Search for other papers by Shingo Suzuki in
Google Scholar
PubMed
Search for other papers by Shingo Suzuki in
Google Scholar
PubMed
Hiroko Misawa
Hiroko Misawa
Search for other papers by Hiroko Misawa in
Google Scholar
PubMed
Search for other papers by Hiroko Misawa in
Google Scholar
PubMed
Keiko Ishizuka
Keiko Ishizuka
Search for other papers by Keiko Ishizuka in
Google Scholar
PubMed
Search for other papers by Keiko Ishizuka in
Google Scholar
PubMed
Yutaka Oki
Yutaka Oki
Search for other papers by Yutaka Oki in
Google Scholar
PubMed
Search for other papers by Yutaka Oki in
Google Scholar
PubMed
Jaeduk Yoshimura Noh
Jaeduk Yoshimura Noh
Second Division, Ito Hospital, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan
Search for other papers by Jaeduk Yoshimura Noh in
Google Scholar
PubMed
Search for other papers by Jaeduk Yoshimura Noh in
Google Scholar
PubMed
Hirotoshi Nakamura
Hirotoshi Nakamura
Search for other papers by Hirotoshi Nakamura in
Google Scholar
PubMed
Search for other papers by Hirotoshi Nakamura in
Google Scholar
PubMed
holo-enzyme. In the absence of T 3 , TR recruits co-repressors such as nuclear receptor co-repressor or the silencing mediator of retinoic acid and thyroid hormone receptors (SMRT). These co-repressors associate with histone deacetylases (HDACs
Xuan Zhou
Xuan Zhou
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Xuan Zhou in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Xuan Zhou in
Google Scholar
PubMed
Yanan Zhang
Yanan Zhang
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Yanan Zhang in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Yanan Zhang in
Google Scholar
PubMed
Youwen Yuan
Youwen Yuan
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Youwen Yuan in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Youwen Yuan in
Google Scholar
PubMed
Fei Teng
Fei Teng
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Fei Teng in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Fei Teng in
Google Scholar
PubMed
Jiayang Lin
Jiayang Lin
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Jiayang Lin in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Jiayang Lin in
Google Scholar
PubMed
Xueru Ye
Xueru Ye
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Xueru Ye in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Xueru Ye in
Google Scholar
PubMed
Yaojin Pan
Yaojin Pan
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Yaojin Pan in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Yaojin Pan in
Google Scholar
PubMed
Huijie Zhang
Huijie Zhang
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Huijie Zhang in
Google Scholar
PubMed
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China
Search for other papers by Huijie Zhang in
Google Scholar
PubMed
both obligatory and adaptive thermogenesis by directly increasing metabolic rate in specific tissues ( Silva 2003 , Bianco et al. 2005 , Bianco & McAninch 2013 , Johann et al. 2019 ). Thyroid hormone receptors (TRs), including TRα and TRβ, are
Simone Magagnin Wajner
Simone Magagnin Wajner
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Simone Magagnin Wajner in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Simone Magagnin Wajner in
Google Scholar
PubMed
Márcia dos Santos Wagner
Márcia dos Santos Wagner
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Márcia dos Santos Wagner in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Márcia dos Santos Wagner in
Google Scholar
PubMed
Rossana C N Melo
Rossana C N Melo
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Rossana C N Melo in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Rossana C N Melo in
Google Scholar
PubMed
Gleydes G Parreira
Gleydes G Parreira
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Gleydes G Parreira in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Gleydes G Parreira in
Google Scholar
PubMed
Hélio Chiarini-Garcia
Hélio Chiarini-Garcia
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Hélio Chiarini-Garcia in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Hélio Chiarini-Garcia in
Google Scholar
PubMed
Antonio C Bianco
Antonio C Bianco
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Antonio C Bianco in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Antonio C Bianco in
Google Scholar
PubMed
Csaba Fekete
Csaba Fekete
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Csaba Fekete in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Csaba Fekete in
Google Scholar
PubMed
Edith Sanchez
Edith Sanchez
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Edith Sanchez in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Edith Sanchez in
Google Scholar
PubMed
Ronald M Lechan
Ronald M Lechan
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Ronald M Lechan in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Ronald M Lechan in
Google Scholar
PubMed
Ana Luiza Maia
Ana Luiza Maia
Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Ana Luiza Maia in
Google Scholar
PubMed
Laboratory of Cellular Biology, Department of Biology, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Laboratory of Structural Biology and Reproduction, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary
Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts, USA
Search for other papers by Ana Luiza Maia in
Google Scholar
PubMed
testis was considered for years to be a thyroid hormone unresponsive organ, a concept based on data showing minimal levels of testicular thyroid hormone receptors (TRs) and lack of thyroid hormone effects on oxygen consumption in adult rat testes
S-Y Chan
S-Y Chan
Department of Fetal Medicine, Division of Reproductive & Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by S-Y Chan in
Google Scholar
PubMed
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by S-Y Chan in
Google Scholar
PubMed
J A Franklyn
J A Franklyn
Department of Fetal Medicine, Division of Reproductive & Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by J A Franklyn in
Google Scholar
PubMed
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by J A Franklyn in
Google Scholar
PubMed
H N Pemberton
H N Pemberton
Department of Fetal Medicine, Division of Reproductive & Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by H N Pemberton in
Google Scholar
PubMed
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by H N Pemberton in
Google Scholar
PubMed
J N Bulmer
J N Bulmer
Department of Fetal Medicine, Division of Reproductive & Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by J N Bulmer in
Google Scholar
PubMed
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by J N Bulmer in
Google Scholar
PubMed
T J Visser
T J Visser
Department of Fetal Medicine, Division of Reproductive & Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by T J Visser in
Google Scholar
PubMed
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by T J Visser in
Google Scholar
PubMed
C J McCabe
C J McCabe
Department of Fetal Medicine, Division of Reproductive & Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by C J McCabe in
Google Scholar
PubMed
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by C J McCabe in
Google Scholar
PubMed
M D Kilby
M D Kilby
Department of Fetal Medicine, Division of Reproductive & Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by M D Kilby in
Google Scholar
PubMed
Division of Medical Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Department of Internal Medicine, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4 LP, UK
Search for other papers by M D Kilby in
Google Scholar
PubMed
potentially modulate thyroid hormone action at a tissue level. These include deiodination of the prohormone T4 to the receptor-binding ligand T3, and the expression of functional thyroid hormone receptor isoforms. The availability of T3 for local receptor
A J Forhead
A J Forhead
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
Search for other papers by A J Forhead in
Google Scholar
PubMed
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
Search for other papers by A J Forhead in
Google Scholar
PubMed
A L Fowden
A L Fowden
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
Search for other papers by A L Fowden in
Google Scholar
PubMed
Search for other papers by A L Fowden in
Google Scholar
PubMed
hormones into target tissues and activation of cellular processes by binding to thyroid hormone receptors (TRs; Fig. 1 ). Before birth, all of these factors show developmental and tissue-specific regulation. In addition, placental transfer of thyroid
Anna de Lloyd
Anna de Lloyd
Department of Child Health, Centre for Endocrine and Diabetes Sciences
Search for other papers by Anna de Lloyd in
Google Scholar
PubMed
Search for other papers by Anna de Lloyd in
Google Scholar
PubMed
James Bursell
James Bursell
Department of Child Health, Centre for Endocrine and Diabetes Sciences
Search for other papers by James Bursell in
Google Scholar
PubMed
Search for other papers by James Bursell in
Google Scholar
PubMed
John W Gregory
John W Gregory
Department of Child Health, Centre for Endocrine and Diabetes Sciences
Search for other papers by John W Gregory in
Google Scholar
PubMed
Search for other papers by John W Gregory in
Google Scholar
PubMed
D Aled Rees
D Aled Rees
Department of Child Health, Centre for Endocrine and Diabetes Sciences
Search for other papers by D Aled Rees in
Google Scholar
PubMed
Search for other papers by D Aled Rees in
Google Scholar
PubMed
Marian Ludgate
Marian Ludgate
Department of Child Health, Centre for Endocrine and Diabetes Sciences
Search for other papers by Marian Ludgate in
Google Scholar
PubMed
Search for other papers by Marian Ludgate in
Google Scholar
PubMed
metabolism and homeostasis ( Williams 2009 ). This postulate is supported by data from mice lacking α 1 and β 1 thyroid hormone receptors, which were found to have skeletal morphogenesis and growth plate abnormalities but no uncoupling of osteoclast and
E M de Vries
E M de Vries
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Search for other papers by E M de Vries in
Google Scholar
PubMed
Search for other papers by E M de Vries in
Google Scholar
PubMed
H C van Beeren
H C van Beeren
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Search for other papers by H C van Beeren in
Google Scholar
PubMed
Search for other papers by H C van Beeren in
Google Scholar
PubMed
M T Ackermans
M T Ackermans
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Search for other papers by M T Ackermans in
Google Scholar
PubMed
Search for other papers by M T Ackermans in
Google Scholar
PubMed
A Kalsbeek
A Kalsbeek
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Search for other papers by A Kalsbeek in
Google Scholar
PubMed
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Search for other papers by A Kalsbeek in
Google Scholar
PubMed
E Fliers
E Fliers
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Search for other papers by E Fliers in
Google Scholar
PubMed
Search for other papers by E Fliers in
Google Scholar
PubMed
A Boelen
A Boelen
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Search for other papers by A Boelen in
Google Scholar
PubMed
Search for other papers by A Boelen in
Google Scholar
PubMed
(upper panel) and the thyroid hormone receptors TR a1 , TRa2 , and TRb1 (lower panel) in the fasting (circles) and restriction (squares) experiment. Open circles and squares represent ad libitum fed control rats, closed circles the 36-h fasted
Stefan Groeneweg
Stefan Groeneweg
Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
Search for other papers by Stefan Groeneweg in
Google Scholar
PubMed
Search for other papers by Stefan Groeneweg in
Google Scholar
PubMed
Robin P Peeters
Robin P Peeters
Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
Search for other papers by Robin P Peeters in
Google Scholar
PubMed
Search for other papers by Robin P Peeters in
Google Scholar
PubMed
Theo J Visser
Theo J Visser
Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
Search for other papers by Theo J Visser in
Google Scholar
PubMed
Search for other papers by Theo J Visser in
Google Scholar
PubMed
W Edward Visser
W Edward Visser
Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
Search for other papers by W Edward Visser in
Google Scholar
PubMed
Search for other papers by W Edward Visser in
Google Scholar
PubMed
-1241.2004.00037.x 15587780 Chatzitomaris A Köditz R Höppner W Peters S Klein HH Dietrich JW 2015 A novel de novo mutation in the thyroid hormone receptor-beta gene. Experimental and Clinical Endocrinology and Diabetes 123 1 – 3
P Venditti
P Venditti
Search for other papers by P Venditti in
Google Scholar
PubMed
Search for other papers by P Venditti in
Google Scholar
PubMed
G Chiellini
G Chiellini
Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy
Search for other papers by G Chiellini in
Google Scholar
PubMed
Search for other papers by G Chiellini in
Google Scholar
PubMed
L Di Stefano
L Di Stefano
Search for other papers by L Di Stefano in
Google Scholar
PubMed
Search for other papers by L Di Stefano in
Google Scholar
PubMed
G Napolitano
G Napolitano
Search for other papers by G Napolitano in
Google Scholar
PubMed
Search for other papers by G Napolitano in
Google Scholar
PubMed
R Zucchi
R Zucchi
Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy
Search for other papers by R Zucchi in
Google Scholar
PubMed
Search for other papers by R Zucchi in
Google Scholar
PubMed
A Columbano
A Columbano
Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy
Search for other papers by A Columbano in
Google Scholar
PubMed
Search for other papers by A Columbano in
Google Scholar
PubMed
T S Scanlan
T S Scanlan
Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy
Search for other papers by T S Scanlan in
Google Scholar
PubMed
Search for other papers by T S Scanlan in
Google Scholar
PubMed
S Di Meo
S Di Meo
Search for other papers by S Di Meo in
Google Scholar
PubMed
Search for other papers by S Di Meo in
Google Scholar
PubMed
of Biochemistry and Biophysics 354 151 – 157 . Chiellini G Apriletti JW Yoshihara HA Baxter JD Ribeiro RC Scanlan TS 1998 A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor . Chemistry & Biology 5
