glucose levels were similar to those of WT mice (113.16 ± 14.03 (WT) vs 125.33 ± 13.19 ( Chrebp −/− ) , respectively). mRNA expression of Srebf2, a key transcription factor controlling synthesis and uptake of cholesterol and their target genes, was
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Ken Takao, Katsumi Iizuka, Yanyan Liu, Teruaki Sakurai, Sodai Kubota, Saki Kubota-Okamoto, Toshinori Imaizumi, Yoshihiro Takahashi, Yermek Rakhat, Satoko Komori, Tokuyuki Hirose, Kenta Nonomura, Takehiro Kato, Masami Mizuno, Tetsuya Suwa, Yukio Horikawa, Masakatsu Sone, and Daisuke Yabe
C G Walker, M C Sugden, G F Gibbons, and M J Holness
activation of peroxisome proliferator-activated receptor (PPAR) γ ( Guan et al. 2002 , Picard & Auwerx 2002 , Tordjman et al. 2003 , Li et al. 2005 ), a lipogenic transcription factor. Contrasting with the role of PPARγ, PPARα acts as a
Alberto Dinarello, Giorgio Licciardello, Camilla Maria Fontana, Natascia Tiso, Francesco Argenton, and Luisa Dalla Valle
transcription factors to regulate gene expression and composite binding in which GC/GR requires both GRE elements and physical interaction with other transcription factors to exert its transcriptional activity. BTM: basal transcription machinery. Once
Elizabeth K Fletcher, Monica Kanki, James Morgan, David W Ray, Lea M Delbridge, Peter J Fuller, Colin D Clyne, and Morag J Young
Introduction The mineralocorticoid receptor (MR) is a ligand-activated transcription factor best known for regulating sodium/potassium and water in the kidney in response to aldosterone ( Fuller & Young 2005 ). The MR has equivalent high
Shaodong Guo
) transcription factor, a family member of the SREBPs that promote lipid and cholesterol synthesis ( Yecies et al . 2011 ). Moreover, mTORC2 and PDK1 suppress the Foxo1 forkhead transcription factor that promotes gluconeogenesis, mediating the effect of insulin
Elika Missaghian, Petra Kempná, Bernhard Dick, Andrea Hirsch, Rasoul Alikhani-Koupaei, Bernard Jégou, Primus E Mullis, Brigitte M Frey, and Christa E Flück
blocking gene transcription. In addition, DNA methylation may block the expression of specific genes by silencing essential transcription factors ( Fluck & Miller 2004 ). DNA methylation has been shown to regulate steroidogenesis. Changes in methylation
Che-Pei Kung and Maureen E Murphy
in genes whose protein products control p53 activity (MDM2 or CDKN2A). Following genotoxic or oncogenic stress, p53 exerts its tumor-suppressive activities mainly by acting as a transcription factor to transactivate gene expression. Under mild stress
Mohammed Bensellam, Jean-Christophe Jonas, and D Ross Laybutt
controlled activation/repression of specific transcription factors and downstream gene clusters in a time-dependent manner. These complex signalling events drive the transition from definitive endoderm cells to mature insulin-secreting β-cells with the
Inga K Johnsen, Marc Slawik, Igor Shapiro, Michaela F Hartmann, Stefan A Wudy, Brendan D Looyenga, Gary D Hammer, Martin Reincke, and Felix Beuschlein
factors such as GATA-4 ( P = 0.0005), Wilms tumor gene-1 (WT-1; P < 0.0001), and steriodogenic factor-1 (SF-1; P = 0.0029) were significantly up-regulated after GDX, while other transcription factors such as FOG-1 ( P < 0.0001) and GATA-6 ( P = 0
L Bouraoui, J Gutiérrez, and I Navarro
(PPARγ) have been identified as transcriptional factors ( MacDougald & Lane 1995 ) and are necessary for the transition of pre-adipocytes into adipocytes in vitro . In mammals, insulin growth factor-I (IGF-I) affects adipocyte proliferation and
