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Ken Takao, Katsumi Iizuka, Yanyan Liu, Teruaki Sakurai, Sodai Kubota, Saki Kubota-Okamoto, Toshinori Imaizumi, Yoshihiro Takahashi, Yermek Rakhat, Satoko Komori, Tokuyuki Hirose, Kenta Nonomura, Takehiro Kato, Masami Mizuno, Tetsuya Suwa, Yukio Horikawa, Masakatsu Sone, and Daisuke Yabe

glucose levels were similar to those of WT mice (113.16 ± 14.03 (WT) vs 125.33 ± 13.19 ( Chrebp −/− ) , respectively). mRNA expression of Srebf2, a key transcription factor controlling synthesis and uptake of cholesterol and their target genes, was

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C G Walker, M C Sugden, G F Gibbons, and M J Holness

activation of peroxisome proliferator-activated receptor (PPAR) γ ( Guan et al. 2002 , Picard & Auwerx 2002 , Tordjman et al. 2003 , Li et al. 2005 ), a lipogenic transcription factor. Contrasting with the role of PPARγ, PPARα acts as a

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Alberto Dinarello, Giorgio Licciardello, Camilla Maria Fontana, Natascia Tiso, Francesco Argenton, and Luisa Dalla Valle

transcription factors to regulate gene expression and composite binding in which GC/GR requires both GRE elements and physical interaction with other transcription factors to exert its transcriptional activity. BTM: basal transcription machinery. Once

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Elizabeth K Fletcher, Monica Kanki, James Morgan, David W Ray, Lea M Delbridge, Peter J Fuller, Colin D Clyne, and Morag J Young

Introduction The mineralocorticoid receptor (MR) is a ligand-activated transcription factor best known for regulating sodium/potassium and water in the kidney in response to aldosterone ( Fuller & Young 2005 ). The MR has equivalent high

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Shaodong Guo

) transcription factor, a family member of the SREBPs that promote lipid and cholesterol synthesis ( Yecies et al . 2011 ). Moreover, mTORC2 and PDK1 suppress the Foxo1 forkhead transcription factor that promotes gluconeogenesis, mediating the effect of insulin

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Elika Missaghian, Petra Kempná, Bernhard Dick, Andrea Hirsch, Rasoul Alikhani-Koupaei, Bernard Jégou, Primus E Mullis, Brigitte M Frey, and Christa E Flück

blocking gene transcription. In addition, DNA methylation may block the expression of specific genes by silencing essential transcription factors ( Fluck & Miller 2004 ). DNA methylation has been shown to regulate steroidogenesis. Changes in methylation

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Che-Pei Kung and Maureen E Murphy

in genes whose protein products control p53 activity (MDM2 or CDKN2A). Following genotoxic or oncogenic stress, p53 exerts its tumor-suppressive activities mainly by acting as a transcription factor to transactivate gene expression. Under mild stress

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Mohammed Bensellam, Jean-Christophe Jonas, and D Ross Laybutt

controlled activation/repression of specific transcription factors and downstream gene clusters in a time-dependent manner. These complex signalling events drive the transition from definitive endoderm cells to mature insulin-secreting β-cells with the

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Inga K Johnsen, Marc Slawik, Igor Shapiro, Michaela F Hartmann, Stefan A Wudy, Brendan D Looyenga, Gary D Hammer, Martin Reincke, and Felix Beuschlein

factors such as GATA-4 ( P = 0.0005), Wilms tumor gene-1 (WT-1; P < 0.0001), and steriodogenic factor-1 (SF-1; P = 0.0029) were significantly up-regulated after GDX, while other transcription factors such as FOG-1 ( P < 0.0001) and GATA-6 ( P = 0

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L Bouraoui, J Gutiérrez, and I Navarro

(PPARγ) have been identified as transcriptional factors ( MacDougald & Lane 1995 ) and are necessary for the transition of pre-adipocytes into adipocytes in vitro . In mammals, insulin growth factor-I (IGF-I) affects adipocyte proliferation and