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Gonzalo Alba Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Consuelo Santa-María Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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María Edith Reyes-Quiroz Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Rajaa El Bekay Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Isabel Geniz Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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José Martín-Nieto Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Elizabeth Pintado Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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Francisco Sobrino Departamento de Bioquímica Médica y Biología Molecular, Departamento de Bioquímica y Biología Molecular, CIBER in Physiopathology of Obesity and Nutrition (CB06/03), Centro de Salud Guillena, Departamento de Fisiología, Facultad de Medicina and

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. Although high concentrations of ROS are catatonic, they are now known to function as signal transducing molecules at lower concentrations, modulating indirectly the activity of many enzymes and transcription factors. Classical regulation of the activity of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0106
Volume/Issue:
Volume 214: Issue 3
Free access
Ken Takao Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Katsumi Iizuka Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yanyan Liu Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Teruaki Sakurai Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Sodai Kubota Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Saki Kubota-Okamoto Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Toshinori Imaizumi Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yoshihiro Takahashi Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yermek Rakhat Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan

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Satoko Komori Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Tokuyuki Hirose Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Kenta Nonomura Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Takehiro Kato Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Masami Mizuno Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Tetsuya Suwa Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Yukio Horikawa Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

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Masakatsu Sone Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

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Daisuke Yabe Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan
Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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glucose levels were similar to those of WT mice (113.16 ± 14.03 (WT) vs 125.33 ± 13.19 ( Chrebp −/− ) , respectively). mRNA expression of Srebf2, a key transcription factor controlling synthesis and uptake of cholesterol and their target genes, was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0442
Volume/Issue:
Volume 248: Issue 3
Restricted access
Myat Theingi Swe Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Department of Physiology, University of Medicine 2, Yangon, Myanmar

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Laongdao Thongnak Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Krit Jaikumkao Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Anchalee Pongchaidecha Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Varanuj Chatsudthipong Research Center of Transport Protein for Medical Innovation, Faculty of Science, Mahidol University, Bangkok, Thailand

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Anusorn Lungkaphin Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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renal cortical tissue in HF rats was attenuated by dapagliflozin and metformin administration ( P  < 0.05) ( Fig. 1I and J ). The effect of dapagliflozin on renal gluconeogenic enzyme expression might be mediated through transcription factors p

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0480
Volume/Issue:
Volume 245: Issue 2
Restricted access
Alberto Dinarello Department of Biology, University of Padova, Padova, Italy

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Giorgio Licciardello Department of Biology, University of Padova, Padova, Italy

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Camilla Maria Fontana Department of Biology, University of Padova, Padova, Italy

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Natascia Tiso Department of Biology, University of Padova, Padova, Italy

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Francesco Argenton Department of Biology, University of Padova, Padova, Italy

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Luisa Dalla Valle Department of Biology, University of Padova, Padova, Italy

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transcription factors to regulate gene expression and composite binding in which GC/GR requires both GRE elements and physical interaction with other transcription factors to exert its transcriptional activity. BTM: basal transcription machinery. Once

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0173
Volume/Issue:
Volume 247: Issue 3
Free access
C G Walker Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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M C Sugden Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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G F Gibbons Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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M J Holness Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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activation of peroxisome proliferator-activated receptor (PPAR) γ ( Guan et al. 2002 , Picard & Auwerx 2002 , Tordjman et al. 2003 , Li et al. 2005 ), a lipogenic transcription factor. Contrasting with the role of PPARγ, PPARα acts as a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0205
Volume/Issue:
Volume 193: Issue 1
Free access
Elizabeth K Fletcher Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
Tufts Medical Center, Boston, Massachusetts, USA

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Monica Kanki Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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James Morgan Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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David W Ray NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Lea M Delbridge Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia

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Peter J Fuller Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Colin D Clyne Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Morag J Young Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Introduction The mineralocorticoid receptor (MR) is a ligand-activated transcription factor best known for regulating sodium/potassium and water in the kidney in response to aldosterone ( Fuller & Young 2005 ). The MR has equivalent high

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0584
Volume/Issue:
Volume 241: Issue 1
Free access
Shaodong Guo Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M University Health Science Center, Scott & White, Central Texas Veterans Health Care System, 1901 South 1st Street, Bldg. 205, Temple, Texas 76504, USA

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) transcription factor, a family member of the SREBPs that promote lipid and cholesterol synthesis ( Yecies et al . 2011 ). Moreover, mTORC2 and PDK1 suppress the Foxo1 forkhead transcription factor that promotes gluconeogenesis, mediating the effect of insulin

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0327
Volume/Issue:
Volume 220: Issue 2
Free access
Elika Missaghian Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Petra Kempná Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Bernhard Dick Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Andrea Hirsch Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Rasoul Alikhani-Koupaei Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Bernard Jégou Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Primus E Mullis Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Brigitte M Frey Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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Christa E Flück Pediatric Endocrinology and Diabetology, Department of Nephrology and Hypertension, Inserm, University Children's Hospital Bern

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blocking gene transcription. In addition, DNA methylation may block the expression of specific genes by silencing essential transcription factors ( Fluck & Miller 2004 ). DNA methylation has been shown to regulate steroidogenesis. Changes in methylation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0353
Volume/Issue:
Volume 202: Issue 1
Free access
Che-Pei Kung Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA

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Maureen E Murphy Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA

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in genes whose protein products control p53 activity (MDM2 or CDKN2A). Following genotoxic or oncogenic stress, p53 exerts its tumor-suppressive activities mainly by acting as a transcription factor to transactivate gene expression. Under mild stress

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0324
Volume/Issue:
Volume 231: Issue 2
Free access
Mohammed Bensellam Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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Jean-Christophe Jonas Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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D Ross Laybutt Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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controlled activation/repression of specific transcription factors and downstream gene clusters in a time-dependent manner. These complex signalling events drive the transition from definitive endoderm cells to mature insulin-secreting β-cells with the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0516
Volume/Issue:
Volume 236: Issue 2
Free access