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Margo P Emont Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA
Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

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Hui Yu Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

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Jun Wu Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA
Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

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interacts with both PPARγ and C/EBPβ to drive thermogenesis. Other transcriptional regulators of thermogenesis include EBF2, which forms a ribonucleoprotein complex with Blinc1 to upregulate thermogenic genes. In white adipocytes (right) the PPARγ

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Mohammed Bensellam Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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Jean-Christophe Jonas Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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D Ross Laybutt Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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Zhang W Xu S Lin H Wang Z Liu H Fang Q Li C Peng L Lou J 2014 TRIB3 alters endoplasmic reticulum stress-induced beta-cell apoptosis via the NF-kappaB pathway . Metabolism 63 822 – 830 . ( https://doi.org/10

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Michael C Velarde Institute of Biology, University of the Philippines Diliman, Quezon City, Philippines
Buck Institute for Research on Aging, Novato, California, USA

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Ramkumar Menon Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
Department of Clinical Medicine and Obstetrics and Gynecology, Aarhus University, Aarhus, Denmark

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). Moreover, markers of cellular senescence are observed in human syncytiotrophoblasts after fusion of cytotrophoblasts ( Chuprin et al. 2013 ). After fusion, these senescent cells also secrete SASP components, such as interleukin 6 (IL6), IL8, chemokine C-X-C

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R L Moore Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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Y Dai Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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D V Faller Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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. Yuan J Dykhouse K Lou Z 2009 Abstract #4441: c-Myc/SIRT1 feedback loop: a novel regulation of c-Myc induced cellular transformation . AACR Meeting Abstracts 2009 4441 . Zhang DY Li SY Cruz P Kone BC 2009 Sirtuin 1 functionally

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Koen D Flach Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wilbert Zwart Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Jin S Lou C 2009 AIB1 is required for the acquisition of epithelial growth factor receptor-mediated tamoxifen resistance in breast cancer cells . Biochemical and Biophysical Research Communications 380 699 – 704 . ( doi:10.1016/j

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Cátia F Gonçalves Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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Qing-Jun Meng Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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W Rigueur D Lyons KM 2014 TGFβ signaling in cartilage development and maintenance . Birth Defects Research: Part C, Embryo Today: Reviews 37 – 51 . ( https://doi.org/10.1002/bdrc.21058 ) 24677722 Xian L Wu X Pang L Lou M Rosen

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Harman S Mattu Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

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Harpal S Randeva Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

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. (2003) ↓Apoptosis Mouse in vivo McGaffin et al . (2008) Rat cardiomyocytes Eguchi et al . (2008) ↓Cardiac output Rat cardiomyocytes Nickola et al . (2000) ↑MABP, HR Rat in vivo (i.v.) Shek et al . (1998) Rat in vivo (i.c.v.) Satoh et al . (1999

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Sergio Di Meo Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Susanna Iossa Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Paola Venditti Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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). Although AKT has several substrates, including atypical protein kinase C (PKC) isoforms and glycogen synthase kinase 3 (GSK3), another substrate of 160 kDa (AS160), has emerged as an additional molecule important in the activation of glucose transport in

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Bruce S McEwen Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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Jason D Gray Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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Carla Nasca Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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/bhp003 ) Shansky RM Hamo C Hof PR Lou W McEwen BS Morrison JH 2010 Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathway . Cerebral Cortex 20 2560 – 2567 . ( doi:10.1093/cercor/bhq003 ) Sheline YI 2003

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Hongjuan Shi Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Tian Gao Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Zhilong Liu Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Lina Sun Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Xiaolong Jiang Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Lili Chen Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Deshou Wang Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Nile tilapia were reared in recirculating aerated freshwater tanks at 26°C under a natural photoperiod. All-XX progenies were obtained by crossing an XX pseudomale with a normal XX female. All-XY progenies were obtained by crossing an YY supermale with

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