Search Results

You are looking at 71 - 80 of 1,900 items for :

  • Refine by Access: All content x
Clear All
Free access

Sojin Lee and H Henry Dong

mutations in FoxO genes or altered expression of FoxO proteins are associated with diseases including diabetes and cancer or with reduced lifespan in mammals. This latter aspect is exemplified by the illustration of role of the FoxO ortholog Daf16 in

Free access

Sergio Di Meo, Susanna Iossa, and Paola Venditti

Introduction In recent years, the observation that insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are growing dramatically all over the world has stimulated the research on such metabolic disorders and their possible therapy. At

Free access

Nicole G Barra, Fernando F Anhê, Joseph F Cavallari, Anita M Singh, Darryl Y Chan, and Jonathan D Schertzer

extraction from food ( Bäckhed et al. 2007 ). The gut microbiota can also influence blood glucose. Lower bacterial diversity correlates with insulin resistance and higher adiposity (reviewed in Zhu & Goodarzi 2020 ). Type 2 diabetes (T2D) is associated

Free access

Thanh Q Dang, Nanyoung Yoon, Helen Chasiotis, Emily C Dunford, Qilong Feng, Pingnian He, Michael C Riddell, Scott P Kelly, and Gary Sweeney

potent effects on restricting endothelial transport ( Felinski & Antonetti 2005 , Witt & Sandoval 2014 ), and they contribute to the development of diabetes at least in part by increasing hepatic glucose production and reducing GLUT4 translocation in

Free access

Ling He, Shumei Meng, Emily L Germain-Lee, Sally Radovick, and Fredric E Wondisford

Introduction Diabetes mellitus is increasing in prevalence worldwide due to dietary excesses and sedentary lifestyles. About 25.8 million individuals in the USA have diabetes, accounting for 8.3% of the population. Type 2 diabetes previously was

Free access

Morten Lundh, Marco Bugliani, Tina Dahlby, Danny Hung-Chieh Chou, Bridget Wagner, Seyed Mojtaba Ghiasi, Vincenzo De Tata, Zhifei Chen, Marianne Nissan Lund, Michael J Davies, Piero Marchetti, and Thomas Mandrup-Poulsen

animal models, and our study clarifies the translational potential of this concept, in that our data in human islets do not support the use of inhibitors selective for the i-proteasome in diabetes. In conclusion, beta cells upregulate immunoproteasome

Restricted access

Aryane Cruz Oliveira Pinho, Diana Santos, Inês Baldeiras, Ana Burgeiro, Emelindo C Leal, and Eugenia Carvalho

as cardiac disease development and progression, such as atherosclerosis, especially under diabetes condition ( Chatterjee et al. 2009 , Nosalski & Guzik 2017 , Aldiss et al. 2019 , Poznyak et al. 2020 , Cutruzzolà et al. 2021 ). As

Free access

Sara S Ellingwood and Alan Cheng

there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding This work was supported in part by the American Diabetes Association (#1-17-IBS-135 to A C). S S E was supported by the National

Free access

Subhshri Sahu, David Tosh, and Anandwardhan A Hardikar

Introduction Cell-replacement therapy involves treating diseases with functional cells derived from sources including the body's own cells. Successful cell replacement therapy in diabetes requires sufficient numbers of insulin-producing cells to be

Free access

Emma J Hamilton and Stephen M Twigg

Introduction Diabetes-related foot disease (DFD) is defined as ulceration, infection or destruction of tissues of the foot in a person with current or previously diagnosed diabetes mellitus, usually associated with the risk factors of