mutations in FoxO genes or altered expression of FoxO proteins are associated with diseases including diabetes and cancer or with reduced lifespan in mammals. This latter aspect is exemplified by the illustration of role of the FoxO ortholog Daf16 in
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Sergio Di Meo, Susanna Iossa, and Paola Venditti
Introduction In recent years, the observation that insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are growing dramatically all over the world has stimulated the research on such metabolic disorders and their possible therapy. At
Nicole G Barra, Fernando F Anhê, Joseph F Cavallari, Anita M Singh, Darryl Y Chan, and Jonathan D Schertzer
extraction from food ( Bäckhed et al. 2007 ). The gut microbiota can also influence blood glucose. Lower bacterial diversity correlates with insulin resistance and higher adiposity (reviewed in Zhu & Goodarzi 2020 ). Type 2 diabetes (T2D) is associated
Thanh Q Dang, Nanyoung Yoon, Helen Chasiotis, Emily C Dunford, Qilong Feng, Pingnian He, Michael C Riddell, Scott P Kelly, and Gary Sweeney
potent effects on restricting endothelial transport ( Felinski & Antonetti 2005 , Witt & Sandoval 2014 ), and they contribute to the development of diabetes at least in part by increasing hepatic glucose production and reducing GLUT4 translocation in
Ling He, Shumei Meng, Emily L Germain-Lee, Sally Radovick, and Fredric E Wondisford
Introduction Diabetes mellitus is increasing in prevalence worldwide due to dietary excesses and sedentary lifestyles. About 25.8 million individuals in the USA have diabetes, accounting for 8.3% of the population. Type 2 diabetes previously was
Morten Lundh, Marco Bugliani, Tina Dahlby, Danny Hung-Chieh Chou, Bridget Wagner, Seyed Mojtaba Ghiasi, Vincenzo De Tata, Zhifei Chen, Marianne Nissan Lund, Michael J Davies, Piero Marchetti, and Thomas Mandrup-Poulsen
animal models, and our study clarifies the translational potential of this concept, in that our data in human islets do not support the use of inhibitors selective for the i-proteasome in diabetes. In conclusion, beta cells upregulate immunoproteasome
Aryane Cruz Oliveira Pinho, Diana Santos, Inês Baldeiras, Ana Burgeiro, Emelindo C Leal, and Eugenia Carvalho
as cardiac disease development and progression, such as atherosclerosis, especially under diabetes condition ( Chatterjee et al. 2009 , Nosalski & Guzik 2017 , Aldiss et al. 2019 , Poznyak et al. 2020 , Cutruzzolà et al. 2021 ). As
Sara S Ellingwood and Alan Cheng
there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding This work was supported in part by the American Diabetes Association (#1-17-IBS-135 to A C). S S E was supported by the National
Subhshri Sahu, David Tosh, and Anandwardhan A Hardikar
Introduction Cell-replacement therapy involves treating diseases with functional cells derived from sources including the body's own cells. Successful cell replacement therapy in diabetes requires sufficient numbers of insulin-producing cells to be
Emma J Hamilton and Stephen M Twigg
Introduction Diabetes-related foot disease (DFD) is defined as ulceration, infection or destruction of tissues of the foot in a person with current or previously diagnosed diabetes mellitus, usually associated with the risk factors of
