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Marika Bogdani
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Angela M Henschel Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Sanjay Kansra Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Jessica M Fuller Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Rhonda Geoffrey Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Shuang Jia Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Mary L Kaldunski Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Scott Pavletich Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Simon Prosser Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Yi-Guang Chen Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Åke Lernmark Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Martin J Hessner Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Introduction Type 1 diabetes (T1D) is an autoimmune disease characterized by immunocyte infiltration of the pancreatic islets (insulitis) and destruction of the insulin-secreting β cells. Diabetes in the biobreeding (BB) rat exhibits many

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0385
Volume/Issue:
Volume 216: Issue 2
Free access
Wenpeng Dong Dialysis Center, Daqing Oilfield General Hospital, Daqing, Heilongjiang, People’s Republic of China
Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Ye Jia Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Xiuxia Liu Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Huan Zhang Operating theatre, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Tie Li Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Wenlin Huang School of Science and Technology, Georgia Gwinnett College, Lawrenceville, Georgia, USA

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Xudong Chen Gastroenterology Department No. 1, Jilin Central General Hospital, Jilin, Jilin, People’s Republic of China

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Fuchun Wang Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Weixia Sun Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Hao Wu Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Introduction As one of the long-term complications of diabetes, diabetic nephropathy (DN) is the main cause of end-stage renal disease ( Dronavalli et al . 2008 ). Thus, end-stage renal disease cannot be effectively prevented or treated

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0322
Volume/Issue:
Volume 232: Issue 1
Free access
Qiaoli Cui Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Yijing Liao Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Yaojing Jiang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Xiaohang Huang Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Weihong Tao Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Quanquan Zhou Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Anna Shao Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Ying Zhao Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Jia Li Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Anran Ma Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Zhihong Wang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Li Zhang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Zunyuan Yang Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Yinan Liang Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Minglin Wu Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Zhenyan Yang Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Wen Zeng Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Qinghua Wang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China
Keenan Research Centre for Biomedical Science, Division of Endocrinology and Metabolism, St. Michael’s Hospital, Toronto, Ontario, Canada

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methods Animals Male rhesus monkeys with spontaneous type 2 diabetes were provided and housed in Sichuan Primed Shines Bio-tech Co., Ltd. (SPSB). Before the experiments, the animals were quarantined and received a physical examination, two

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0255
Volume/Issue:
Volume 248: Issue 2
Restricted access
Kanta Kon Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Hiroshi Tsuneki Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Hisakatsu Ito Department of Anesthesiology, University of Toyama, Sugitani, Toyama, Japan

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Yoshinori Takemura Department of Anesthesiology, University of Toyama, Sugitani, Toyama, Japan

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Kiyofumi Sato Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Mitsuaki Yamazaki Department of Anesthesiology, University of Toyama, Sugitani, Toyama, Japan

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Yoko Ishii Department of Pathology, University of Toyama, Sugitani, Toyama, Japan

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Masakiyo Sasahara Department of Pathology, University of Toyama, Sugitani, Toyama, Japan

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Assaf Rudich Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Takahiro Maeda Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Tsutomu Wada Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Toshiyasu Sasaoka Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Introduction The prevalence of lifestyle-related disorders, including insomnia, obesity and type 2 diabetes is increasing worldwide, mainly due to dramatic changes in living environments in modern society. Evidence indicates that environmental

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0708
Volume/Issue:
Volume 243: Issue 1
Free access
P Brandimarti Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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J M Costa-Júnior Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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S M Ferreira Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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A O Protzek Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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G J Santos Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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E M Carneiro Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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A C Boschero Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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L F Rezende Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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Introduction Type 2 diabetes is a complex illness mainly characterized by hyperglycemia, usually accompanied by pancreatic islets malfunction, and reduced insulin sensitivity, as well as lower insulin clearance. Although hyperglycemia is one of the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0177
Volume/Issue:
Volume 219: Issue 2
Free access
Paul Millar SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Nupur Pathak SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Vadivel Parthsarathy SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Anthony J Bjourson Northern Ireland Centre for Stratified Medicine, University of Ulster, C-TRIC Building, Altnagelvin Hospital, Northern Ireland, UK

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Maurice O’Kane Northern Ireland Centre for Stratified Medicine, University of Ulster, C-TRIC Building, Altnagelvin Hospital, Northern Ireland, UK
Clinical Chemistry Laboratory, Western Health and Social Care Trust, Altnagelvin Hospital, Northern Ireland, UK

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Varun Pathak SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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R Charlotte Moffett SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Peter R Flatt SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Victor A Gault SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disorder that arises due to a complex array of molecular defects manifesting in dysregulated insulin secretion, impaired insulin action or both. Since the pathophysiology of T2DM is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0263
Volume/Issue:
Volume 234: Issue 3
Free access
Xiaoyi Ma Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Fei Gao Department of Orthopedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Qi Chen Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiuping Xuan Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Ying Wang Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Hongjun Deng Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Fengying Yang Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Li Yuan Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Introduction Type 2 diabetes mellitus (T2DM) is characterized by progressive beta-cell dysfunction. In recent years, the incidence of prediabetes and T2DM has steadily increased ( Kehlenbrink et al . 2019 ). Moreover, the incidence of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0471
Volume/Issue:
Volume 246: Issue 3
Restricted access
Mari van de Vyver Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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. 2023 ). Figure 1 Factors contributing to chronic inflammation in type 2 diabetes. Continuous activation signals are derived from multiple sources including, dysfunctional adipose tissue, the aberrant metabolic activation of leukocytes, damage

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0271
Volume/Issue:
Volume 257: Issue 1
Free access
Sarah L Craig SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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Victor A Gault SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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Gerd Hamscher Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Giessen, Germany

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Nigel Irwin SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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Introduction Dipeptidyl peptidase-4 (DPP-4) inhibitors are an orally available class of drugs, clinically approved for the treatment of type 2 diabetes mellitus (T2DM) ( Scott 2017 ). The primary therapeutic benefit of DPP-4 inhibitors in T2DM

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0557
Volume/Issue:
Volume 245: Issue 2
Restricted access
Vanesa Jiménez-Amilburu Institute of Biology, ZF‐screens BV, Hubrecht Institute‐KNAW and University Medical Center Utrecht and Interuniversity, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands

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Susanne Jong-Raadsen Institute of Biology, ZF‐screens BV, Hubrecht Institute‐KNAW and University Medical Center Utrecht and Interuniversity, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands

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Jeroen Bakkers Institute of Biology, ZF‐screens BV, Hubrecht Institute‐KNAW and University Medical Center Utrecht and Interuniversity, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands

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Herman P Spaink Institute of Biology, ZF‐screens BV, Hubrecht Institute‐KNAW and University Medical Center Utrecht and Interuniversity, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands

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Rubén Marín-Juez Institute of Biology, ZF‐screens BV, Hubrecht Institute‐KNAW and University Medical Center Utrecht and Interuniversity, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands

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glycemic control present one of the main risk factors for developing heart failure ( Haslam & James 2005 ). Specially, type 2 diabetes (T2D) is strongly associated with heart failure ( Bell 2003 a ). Patients with T2D present an increased incidence of heart

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0539
Volume/Issue:
Volume 224: Issue 1
Free access