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Introduction The enzymatic synthesis of the biogenic amines dopamine, histamine, putrescine, and agmatine involves the decarboxylation of the corresponding amino acid by its cognate amino acid decarboxylase ( Hayashi et al . 1990 a , b , Sandmeier
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endocrine profiles and reduce mortality. Somatostatin analogs and dopamine agonists are utilized as principal medications for acromegaly patients before and/or after pituitary surgery. It has been generally recognized that a combination therapy with
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK
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Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK
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Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK
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) Interactions with prostanoid receptors impair GHSR1a constitutive signalling. AGRP, agouti-related peptide; Ca 2+ i , intracellular Ca 2+ ; DRD1, dopamine receptor D1; DRD2, dopamine receptor D2; EP3-I, prostaglandin E 2 receptor subtype EP 3-I ; GHSR1, growth
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ABSTRACT
Bovine corpora lutea and ovarian stroma were analysed by high-performance liquid chromatography for catecholamine content. High concentrations (up to 102 nmol/g wet weight) were found in both 'central' stroma, containing many blood vessels, and 'peripheral' stroma. Central stroma contained noradrenaline and some dopamine, whereas peripheral stroma contained a higher proportion of dopamine and also significant amounts of 3,4-dihydroxyphenylacetic acid (DOPAC). Occasional samples of stroma had very high amounts of dopamine, suggesting that it is stored in specific regions. Corpora lutea, although devoid of direct innervation, contained dopamine (up to 5·3 nmol/g) and noradrenaline (up to 1·2 nmol/g). The average dopamine: noradrenaline molar ratio was 1·19 : 1 and the concentrations of dopamine and noradrenaline were highly correlated (P < 0·002). The concentration of dopamine was significantly higher in the early luteal phase of the oestrous cycle than during the rest of the cycle or in pregnancy. The levels of noradrenaline and dopamine present in corpora lutea are sufficient to modulate the production of both oxytocin and progesterone by luteal cells in vitro.
Journal of Endocrinology (1991) 129, 221–226
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ABSTRACT
A role for the regulation of cellular Ca2+ homeostasis in the dopaminergic control of prolactin secretion was investigated in rat anterior pituitary glands. Withdrawal of dopamine stimulated the uptake of 45Ca2+ into hemipituitary tissue by 48% after 3 min. Radioisotope desaturation from tissue prelabelled with 45Ca2+ was significantly retarded in the presence of dopamine. Withdrawal of dopamine rapidly stimulated 45Ca2+ efflux from prelabelled tissue by 79% and was accompanied by a three- to fourfold rise in prolactin secretion. The 45Ca2+ efflux response to dopamine withdrawal was reduced in tissue prelabelled in the presence of dopamine. Agonist displacement with metoclopramide mimicked the effect of dopamine withdrawal on 45Ca2+ efflux and prolactin secretion.
These observations demonstrate that the stimulation of prolactin release by dopamine withdrawal is accompanied by a redistribution of cellular Ca2+ and support the hypothesis that dopamine inhibits secretion by decreasing Ca2+ influx in the mammotroph cell.
J. Endocr. (1986) 108, 423–429
Agrarian Sector, Federal University of Paraná, Veterinary Hospital, Curitiba, Brazil
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Department of Anatomy, Federal University of Pernambuco, Recife, Brazil
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), generates the production and release of many substances, one among them being dopamine (DA). This participates in the neural mechanisms of behavior controls feeding through the action of dopaminergic D 1 and D 2 receptors ( Yamamoto 2006 , Beaulieu
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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-rat ERα and mouse monoclonal anti-dopamine-β-hydroxylase (DBH; Chemicon International, Temecula, CA, USA) using an indirect immunofluorescence technique that has been described previously ( Reyes et al. 2001 ). Tissue sections were incubated in a
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. 2002 , Samson et al . 2003 ) and amongst them, salsolinol that paradoxically may be produced by the inhibitory NEDA system ( Mravec 2006 ). As reported by Naoi et al . (1996 , 2002) , salsolinol can be synthesized from dopamine (DA) and
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A study has been made of the effects of chemical sympathectomy and ganglion blockade on the responses of rat jejunum in vivo to intravenous doses of angiotensin and noradrenaline capable of stimulating fluid transport. Pretreatment with 6-hydroxydopamine (chemical sympathectomy) or pentolinium tartrate (ganglion blockade) abolished the stimulatory actions of angiotensin II but left the responses to noradrenaline unimpaired. Dopamine, like noradrenaline, stimulated fluid transport but this response required very high dopamine infusion rates, was refractory to the dopamine antagonist sulpiride and was inhibited by the α-blocker phentolamine.
The possible interaction between angiotensin and the intestinal sympathetics is discussed with reference to control of extracellular fluid volume.
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Introduction Prolactinomas are the most common subtype of pituitary adenomas (proportion, 40–66%), with a prevalence of 6–10 cases per 100,000 per year ( Gillam et al. 2006 , Wu et al. 2006 ). Dopamine agonists (DAs), such as
